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• W2045688529 abstract "Background and Objectives:We evaluated maintenance of response to atomoxetineduring a 25-week, double-blind, placebo-controlled, randomised withdrawal periodin adults with attention-deficit/hyperactivity disorder (ADHD) who previously respondedto atomoxetine during a 12 week open-label treatment period and maintained thatresponse during a 12-week double-blind maintenance period.Methods: Patients (N = 2017), 18 to 50 years of age, diagnosed with ADHD from 152outpatient sites in 18 countries received 12 weeks of open-label atomoxetine (40-100mg/day) followed by 12 weeks of double-blind maintenance (80 or 100 mg/day). Responderswere randomized to atomoxetine (N = 266) or placebo (N = 258) for 25-weeks ofdouble-blind treatment. The percentage of patients with a reduction .30% in their baselineConners�f ADHD Rating Scale Investigator-Rated: Screening Version (CAARS-Inv:SV)total score and a score of .3 on the Clinical Global Impression ADHD-Severity (CGIADHD-S) after 25 weeks was compared between treatment groups with a Fisher�fs exacttest. Mean changes from baseline in the CAARS-Inv:SV and Adult Attention-Deficit/HyperactivityDisorder Quality of Life (AAQoL) were analysed.Results: Most patients enrolled (60%) were from Europe. More atomoxetine- than placebo-treated patients maintained a satisfactory response postrandomisation (64.3% vs. 50.0%;p <.001). Time-to-relapse was significantly longer for atomoxetine than placebo (p = .004).Atomoxetine maintained greater improvements in ADHD symptoms compared with placebo(LS mean worsening in the CAARS-Inv:SV total score was 0.9 vs. 4.8 [p <.001] and in theCGI-ADHD-S rating was 0.0 vs. 0.5 [p <.001]). These results were supported by self- or observer-rated measures. Lastly, atomoxetine maintained greater improvements in quality oflife compared with placebo (AAQoL total score was 0.4 vs. -4.0; p = .002).Conclusions: This study demonstrated that atomoxetine was superior to placebo inmaintaining significantly greater treatment responses for up to 1 year in adults with ADHD." @default.
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• W2045688529 date "2013-09-01" @default.
• W2045688529 modified "2023-10-03" @default.
• W2045688529 title "Maintenance of response after open-label treatment with atomoxetine hydrochloride in international European and non-European adult outpatients with attention-deficit/hyperactivity disorder: a placebo-controlled, randomised withdrawal study" @default.
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• W2045688529 doi "https://doi.org/10.4321/s0213-61632013000300004" @default.
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