Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046303669> ?p ?o ?g. }
- W2046303669 endingPage "135" @default.
- W2046303669 startingPage "127" @default.
- W2046303669 abstract "Information on the intestinal transport of l-3,4-dihydroxyphenylalanine (l-DOPA) is scarce. We present here the functional characteristics and regulation of the apical inward l-DOPA transport in two intestinal epithelial cell lines (human Caco-2 and rat IEC-6). The inward transfer of l-DOPA and l-leucine was promoted through an energy-driven system but with different sensitivity to extracellular Na+ concentration: a minor component of l-leucine uptake (∼25%) was found to require extracellular Na+ in comparison with l-DOPA transport which was Na+-independent. l-DOPA and l-leucine uptake was insensitive to N-(methylamino)-isobutyric acid, but competitively inhibited by 2-aminobicyclo(2,2,1)-heptane-2-carboxylic acid (BCH). l- and d-neutral amino acids, but not acidic and basic amino acids, markedly inhibited l-DOPA and [14C]l-leucine accumulation in both cell lines. The [14C]l-DOPA and [14C]l-leucine outward were markedly increased by l-leucine and BCH present in extracellular medium, but not by l-arginine. In both cell lines, l-DOPA transport was stimulated by acidic pH in comparison with [14C]l-leucine inward which was pH-independent. In conclusion, it is likely that system B0 might be responsible for the Na+-dependent uptake of l-leucine in Caco-2 and IEC-6 cells, whereas sodium-independent uptake of l-leucine and l-DOPA may include system type 1 and type 2 l-amino acid transporter (LAT1 and LAT2), the activation of which results in trans-stimulation of substrates outward transfer." @default.
- W2046303669 created "2016-06-24" @default.
- W2046303669 creator A5030135144 @default.
- W2046303669 creator A5031480776 @default.
- W2046303669 creator A5058065577 @default.
- W2046303669 date "2002-04-01" @default.
- W2046303669 modified "2023-10-14" @default.
- W2046303669 title "The l-3,4-dihydroxyphenylalanine transporter in human and rat epithelial intestinal cells is a type 2 hetero amino acid exchanger" @default.
- W2046303669 cites W1573505398 @default.
- W2046303669 cites W1904678284 @default.
- W2046303669 cites W1951777904 @default.
- W2046303669 cites W1965647269 @default.
- W2046303669 cites W1973308376 @default.
- W2046303669 cites W1982958681 @default.
- W2046303669 cites W2023253424 @default.
- W2046303669 cites W2071555543 @default.
- W2046303669 cites W2076023927 @default.
- W2046303669 cites W2078015619 @default.
- W2046303669 cites W2088839227 @default.
- W2046303669 cites W2089982099 @default.
- W2046303669 cites W2094220461 @default.
- W2046303669 cites W2125380985 @default.
- W2046303669 cites W2142157313 @default.
- W2046303669 cites W2143545078 @default.
- W2046303669 cites W2145806440 @default.
- W2046303669 cites W2159806870 @default.
- W2046303669 cites W2161024237 @default.
- W2046303669 cites W2182142602 @default.
- W2046303669 cites W2205633061 @default.
- W2046303669 cites W2233773111 @default.
- W2046303669 cites W4293247451 @default.
- W2046303669 doi "https://doi.org/10.1016/s0014-2999(02)01416-4" @default.
- W2046303669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12063083" @default.
- W2046303669 hasPublicationYear "2002" @default.
- W2046303669 type Work @default.
- W2046303669 sameAs 2046303669 @default.
- W2046303669 citedByCount "26" @default.
- W2046303669 countsByYear W20463036692015 @default.
- W2046303669 countsByYear W20463036692016 @default.
- W2046303669 countsByYear W20463036692017 @default.
- W2046303669 countsByYear W20463036692018 @default.
- W2046303669 countsByYear W20463036692019 @default.
- W2046303669 countsByYear W20463036692020 @default.
- W2046303669 crossrefType "journal-article" @default.
- W2046303669 hasAuthorship W2046303669A5030135144 @default.
- W2046303669 hasAuthorship W2046303669A5031480776 @default.
- W2046303669 hasAuthorship W2046303669A5058065577 @default.
- W2046303669 hasConcept C104317684 @default.
- W2046303669 hasConcept C134018914 @default.
- W2046303669 hasConcept C149011108 @default.
- W2046303669 hasConcept C178790620 @default.
- W2046303669 hasConcept C185592680 @default.
- W2046303669 hasConcept C2776580952 @default.
- W2046303669 hasConcept C2777440324 @default.
- W2046303669 hasConcept C2777468819 @default.
- W2046303669 hasConcept C2780584575 @default.
- W2046303669 hasConcept C2781313199 @default.
- W2046303669 hasConcept C28406088 @default.
- W2046303669 hasConcept C513476851 @default.
- W2046303669 hasConcept C515207424 @default.
- W2046303669 hasConcept C537181965 @default.
- W2046303669 hasConcept C55493867 @default.
- W2046303669 hasConcept C86803240 @default.
- W2046303669 hasConceptScore W2046303669C104317684 @default.
- W2046303669 hasConceptScore W2046303669C134018914 @default.
- W2046303669 hasConceptScore W2046303669C149011108 @default.
- W2046303669 hasConceptScore W2046303669C178790620 @default.
- W2046303669 hasConceptScore W2046303669C185592680 @default.
- W2046303669 hasConceptScore W2046303669C2776580952 @default.
- W2046303669 hasConceptScore W2046303669C2777440324 @default.
- W2046303669 hasConceptScore W2046303669C2777468819 @default.
- W2046303669 hasConceptScore W2046303669C2780584575 @default.
- W2046303669 hasConceptScore W2046303669C2781313199 @default.
- W2046303669 hasConceptScore W2046303669C28406088 @default.
- W2046303669 hasConceptScore W2046303669C513476851 @default.
- W2046303669 hasConceptScore W2046303669C515207424 @default.
- W2046303669 hasConceptScore W2046303669C537181965 @default.
- W2046303669 hasConceptScore W2046303669C55493867 @default.
- W2046303669 hasConceptScore W2046303669C86803240 @default.
- W2046303669 hasIssue "3" @default.
- W2046303669 hasLocation W20463036691 @default.
- W2046303669 hasLocation W20463036692 @default.
- W2046303669 hasOpenAccess W2046303669 @default.
- W2046303669 hasPrimaryLocation W20463036691 @default.
- W2046303669 hasRelatedWork W1592500868 @default.
- W2046303669 hasRelatedWork W2034748216 @default.
- W2046303669 hasRelatedWork W2098467782 @default.
- W2046303669 hasRelatedWork W2146511152 @default.
- W2046303669 hasRelatedWork W2194279484 @default.
- W2046303669 hasRelatedWork W2395544211 @default.
- W2046303669 hasRelatedWork W2569805444 @default.
- W2046303669 hasRelatedWork W2895805313 @default.
- W2046303669 hasRelatedWork W2912906335 @default.
- W2046303669 hasRelatedWork W4301030180 @default.
- W2046303669 hasVolume "441" @default.
- W2046303669 isParatext "false" @default.
- W2046303669 isRetracted "false" @default.
- W2046303669 magId "2046303669" @default.