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• W2047652020 startingPage "30" @default.
• W2047652020 abstract "Major functions of the hippocampus are to generate, organize and store memory. This is a complex process, which is orchestrated by a group of molecules, called plasticity-related molecules. To control these various plasticity-related molecules at the transcriptional level, we have been endowed with cAMP response element-binding protein (CREB), also known as a master regulator of memory. Interestingly, we have seen that this master regulator is regulated at the transcriptional level in the hippocampus by peroxisome proliferator-activated receptor α (PPARα), a nuclear hormone receptor family transcription factor that is known to control the metabolism of fatty acids in the liver, underlying a possible crosstalk between fat and memory. Although liver PPARα does not directly control hippocampal CREB, this opens up an important possibility to improve hippocampal functions and to be resistant to memory loss by PPARα ligands and maintaining normal levels of PPARα in the hippocampus." @default.
• W2047652020 created "2016-06-24" @default.
• W2047652020 creator A5083951715 @default.
• W2047652020 creator A5087133073 @default.
• W2047652020 date "2015-01-10" @default.
• W2047652020 modified "2023-09-30" @default.
• W2047652020 title "PPARα Signaling in the Hippocampus: Crosstalk Between Fat and Memory" @default.
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• W2047652020 doi "https://doi.org/10.1007/s11481-014-9582-9" @default.
• W2047652020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4360966" @default.
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