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• W2051229227 abstract "<h3>Background</h3> Electron-beam computed tomography (EBCT) is a new, noninvasive method of detecting coronary artery calcification that is being increasingly advocated as a diagnostic test for coronary artery disease (CAD). Before its clinical use is justified, however, the overall accuracy of EBCT must be better defined. <h3>Objective</h3> To estimate the accuracy of EBCT in diagnosing obstructive CAD. <h3>Data Sources</h3> English-language studies from January 1, 1979, through Feburary 29, 2000, were retrieved using MEDLINE and Current Contents databases, bibliographies, and expert consultation. <h3>Study Selection</h3> We included a study if it (1) used EBCT as a diagnostic test; (2) reported cases in absolute numbers of true-positive, false-positive, true-negative, and false-negative results; and (3) used coronary angiography as the reference standard for diagnosing obstructive CAD (defined as ≥50% diameter stenosis). <h3>Data Extraction</h3> Data were extracted from the included articles by 2 independent reviewers. <h3>Data Synthesis</h3> Weighted pooled analysis and summary receiver operating characteristic (ROC) curve analysis were used to determine sensitivity and specificity rates. Results from 9 studies with 1662 subjects were included. Pooled sensitivity for EBCT was 92.3% (95% confidence interval [CI], 90.7%-94.0%) and pooled specificity was 51.2% (95% CI, 47.5%-54.9%). Maximum joint sensitivity and specificity for EBCT from its summary ROC curve was 75%. As the threshold for defining an abnormal test varied, sensitivity and specificity changed. For a threshold that resulted in a sensitivity of 90%, specificity was 54%; when sensitivity was 80%, specificity rose to 71%. <h3>Conclusion</h3> The performance of EBCT as a diagnostic test for obstructive CAD is reasonable based on sensitivity and specificity rates from its summary ROC curve." @default.
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• W2051229227 date "2001-03-26" @default.
• W2051229227 modified "2023-09-23" @default.
• W2051229227 title "Electron-Beam Computed Tomography in the Diagnosis of Coronary Artery Disease" @default.
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• W2051229227 doi "https://doi.org/10.1001/archinte.161.6.833" @default.
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