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- W2051244501 abstract "Eukaryotic‐like protein Ser/Thr and Tyr kinases have only recently been discovered in prokaryotes. In most cases, their biochemical properties have been poorly characterized. The nitrogen‐fixing and heterocyst‐forming cyanobacterium Anabaena sp. strain PCC 7120 houses a family of eukaryotic‐like Ser/Thr kinases. Some of these enzymes are required for cell growth or development under certain conditions. None of them, however, has been shown experimentally to possess Ser/Thr kinase activity. A gene, pknC , encoding a novel putative Ser/Thr kinase was isolated from Anabaena sp. PCC 7120. The recombinant PknC was shown to be phosphorylated on a Thr residue. This phosphorylation was probably due to the autophosphorylation activity of PknC itself because mutation of two amino acid residues within the subdomain II of its catalytic domain eliminated the phosphorylation of PknC. PknC displayed also a Ser kinase activity towards several nonspecific substrates, and the two residues needed for PknC autophosphorylation was equally required for the phosphorylation of other substrates. PknC is thus a Ser/Thr kinase with broad substrate specificity. The activity of PknC is likely to be regulated in vivo in order to limit the spectrum of its substrate specificity." @default.
- W2051244501 created "2016-06-24" @default.
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- W2051244501 creator A5063705581 @default.
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- W2051244501 date "2001-03-15" @default.
- W2051244501 modified "2023-09-29" @default.
- W2051244501 title "Characterization of PknC, a Ser/Thr kinase with broad substrate specificity from the cyanobacterium <i>Anabaena</i> sp. strain PCC 7120" @default.
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- W2051244501 doi "https://doi.org/10.1046/j.1432-1327.2001.02057.x" @default.
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