Matches in SemOpenAlex for { <https://semopenalex.org/work/W2051268100> ?p ?o ?g. }
- W2051268100 endingPage "1040" @default.
- W2051268100 startingPage "1037" @default.
- W2051268100 abstract "Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of diabetes mellitus type 1 and type 2. Xanthine oxidase (XO) has been proposed as one of the sources of free radical formation in diabetes. We therefore investigated the preventive effects of Laminaria japonica aqueous extract (LJE) on alterations in the activity of hepatic XO and oxidative stress in the streptozotocin-induced experimental diabetes. We found that lipid peroxide levels and xanthine oxidase activity were increased, whereas glutathione (GSH), GSH reductase and GSH peroxidase were decreased in the liver of streptozotocin-induced diabetic rats. Pretreatment with LJE of 100 mg/kg orally for 5 d significantly reduced blood glucose levels and hepatic lipid peroxidation in the diabetic rats. In addition, the content of glutathione was restored to the control level by LJE pretreatment. Furthermore, LJE significantly suppressed the increased activity of XO and type conversion of the xanthine dehydrogenase to XO in diabetic rat liver. The results suggest that Laminaria japonica would be of great value in preventing hyperglycemia in diabetes mellitus as a dietary supplement possibly, through its antioxidant activity." @default.
- W2051268100 created "2016-06-24" @default.
- W2051268100 creator A5003250918 @default.
- W2051268100 creator A5018502597 @default.
- W2051268100 creator A5028720429 @default.
- W2051268100 creator A5055015781 @default.
- W2051268100 creator A5065166540 @default.
- W2051268100 creator A5080834795 @default.
- W2051268100 date "2004-01-01" @default.
- W2051268100 modified "2023-10-16" @default.
- W2051268100 title "Preventive Effects of Laminaria japonica Aqueous Extract on the Oxidative Stress and Xanthine Oxidase Activity in Streptozotocin-Induced Diabetic Rat Liver" @default.
- W2051268100 cites W1600662889 @default.
- W2051268100 cites W1775749144 @default.
- W2051268100 cites W191109327 @default.
- W2051268100 cites W1977262191 @default.
- W2051268100 cites W1983310681 @default.
- W2051268100 cites W2009033520 @default.
- W2051268100 cites W2030831465 @default.
- W2051268100 cites W2065852951 @default.
- W2051268100 cites W2074611783 @default.
- W2051268100 cites W2079788829 @default.
- W2051268100 cites W2081835270 @default.
- W2051268100 cites W2083755003 @default.
- W2051268100 cites W2089352031 @default.
- W2051268100 cites W2093561173 @default.
- W2051268100 cites W2094992873 @default.
- W2051268100 cites W2097744068 @default.
- W2051268100 cites W2100098015 @default.
- W2051268100 cites W2101198535 @default.
- W2051268100 cites W2115337518 @default.
- W2051268100 cites W2118519973 @default.
- W2051268100 cites W2163527974 @default.
- W2051268100 cites W2416837370 @default.
- W2051268100 cites W4245957869 @default.
- W2051268100 cites W4255669971 @default.
- W2051268100 cites W829757908 @default.
- W2051268100 doi "https://doi.org/10.1248/bpb.27.1037" @default.
- W2051268100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15256736" @default.
- W2051268100 hasPublicationYear "2004" @default.
- W2051268100 type Work @default.
- W2051268100 sameAs 2051268100 @default.
- W2051268100 citedByCount "38" @default.
- W2051268100 countsByYear W20512681002012 @default.
- W2051268100 countsByYear W20512681002013 @default.
- W2051268100 countsByYear W20512681002014 @default.
- W2051268100 countsByYear W20512681002015 @default.
- W2051268100 countsByYear W20512681002017 @default.
- W2051268100 countsByYear W20512681002018 @default.
- W2051268100 countsByYear W20512681002019 @default.
- W2051268100 countsByYear W20512681002020 @default.
- W2051268100 countsByYear W20512681002021 @default.
- W2051268100 countsByYear W20512681002022 @default.
- W2051268100 countsByYear W20512681002023 @default.
- W2051268100 crossrefType "journal-article" @default.
- W2051268100 hasAuthorship W2051268100A5003250918 @default.
- W2051268100 hasAuthorship W2051268100A5018502597 @default.
- W2051268100 hasAuthorship W2051268100A5028720429 @default.
- W2051268100 hasAuthorship W2051268100A5055015781 @default.
- W2051268100 hasAuthorship W2051268100A5065166540 @default.
- W2051268100 hasAuthorship W2051268100A5080834795 @default.
- W2051268100 hasBestOaLocation W20512681001 @default.
- W2051268100 hasConcept C126322002 @default.
- W2051268100 hasConcept C134018914 @default.
- W2051268100 hasConcept C165069038 @default.
- W2051268100 hasConcept C181199279 @default.
- W2051268100 hasConcept C185592680 @default.
- W2051268100 hasConcept C2775838275 @default.
- W2051268100 hasConcept C2776151105 @default.
- W2051268100 hasConcept C2778004101 @default.
- W2051268100 hasConcept C2778102346 @default.
- W2051268100 hasConcept C2778760513 @default.
- W2051268100 hasConcept C2779280383 @default.
- W2051268100 hasConcept C2780829032 @default.
- W2051268100 hasConcept C2993790521 @default.
- W2051268100 hasConcept C538909803 @default.
- W2051268100 hasConcept C55493867 @default.
- W2051268100 hasConcept C555293320 @default.
- W2051268100 hasConcept C71924100 @default.
- W2051268100 hasConcept C86803240 @default.
- W2051268100 hasConceptScore W2051268100C126322002 @default.
- W2051268100 hasConceptScore W2051268100C134018914 @default.
- W2051268100 hasConceptScore W2051268100C165069038 @default.
- W2051268100 hasConceptScore W2051268100C181199279 @default.
- W2051268100 hasConceptScore W2051268100C185592680 @default.
- W2051268100 hasConceptScore W2051268100C2775838275 @default.
- W2051268100 hasConceptScore W2051268100C2776151105 @default.
- W2051268100 hasConceptScore W2051268100C2778004101 @default.
- W2051268100 hasConceptScore W2051268100C2778102346 @default.
- W2051268100 hasConceptScore W2051268100C2778760513 @default.
- W2051268100 hasConceptScore W2051268100C2779280383 @default.
- W2051268100 hasConceptScore W2051268100C2780829032 @default.
- W2051268100 hasConceptScore W2051268100C2993790521 @default.
- W2051268100 hasConceptScore W2051268100C538909803 @default.
- W2051268100 hasConceptScore W2051268100C55493867 @default.
- W2051268100 hasConceptScore W2051268100C555293320 @default.
- W2051268100 hasConceptScore W2051268100C71924100 @default.
- W2051268100 hasConceptScore W2051268100C86803240 @default.
- W2051268100 hasIssue "7" @default.