FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2053204175> ?p ?o ?g. }

• W2053204175 endingPage "696" @default.
• W2053204175 startingPage "683" @default.
• W2053204175 abstract "ABSTRACT Objective: Increased microvascular permeability contributes to the development of diabetic microvascular complications and diabetic vasculopathy is correlated with blood glucose levels. The mechanisms underlying increased permeability, however, are poorly understood. Methods: The Landis‐Michel technique was used to measure water permeability (hydraulic conductivity, L p ) and macromolecular permeability (reflection coefficient, σ) of exchange capillaries in frogs and rats. Results: Dialysed normoglycemic plasma from diabetic patients had no effect on L p . The same plasma with 20 mM glucose increased hydraulic conductivity from (mean ± SEM × 10 −7 cm · s −1 · cm H 2 O –1 ) 5.73 ± 2.01 to 13.09 ± 2.67 ( P < .01). Nondiabetic control plasma did not affect L p , but addition of 20 mM glucose increased L p to a similar degree. The effect of glucose alone was examined. Glucose at 20 mM increased L p , from 2.82 ± 0.61 to 4.71 ± 1.35 × 10 − 7 cm · s − 1 · cm H 2 O –1 ( P = .002, n = 13). A similar increase was seen in rat mesenteric microvessels, from 1.04 ± 0.40 in control perfusions to 2.18 ± 0.56, P < .05. The microvascular macromolecular reflection coefficient in all the above experiments was unaltered. The use of specific inhibitors indicated that the glucose‐induced increased L p did not appear to be mediated through protein kinase C (PKC), free radical generation, glucose metabolism, or albumin glycation. Conclusions: These data suggest that hyperglycemia induced increased apparent protein permeability may be secondary to a glucose‐mediated change in macromolecular convective flux rather than any change in protein permeability per se. The authors speculate that the increased microvascular permeability to water in vivo is mediated by direct interaction of glucose with the endothelial cells (perhaps with the glycocalyx)." @default.
• W2053204175 created "2016-06-24" @default.
• W2053204175 creator A5022667959 @default.
• W2053204175 creator A5023058464 @default.
• W2053204175 creator A5058800719 @default.
• W2053204175 creator A5090260367 @default.
• W2053204175 date "2007-09-10" @default.
• W2053204175 modified "2023-10-16" @default.
• W2053204175 title "Hyperglycemia Stimulates a Sustained Increase in Hydraulic Conductivity In Vivo without Any Change in Reflection Coefficient" @default.
• W2053204175 cites W1479731182 @default.
• W2053204175 cites W1549989427 @default.
• W2053204175 cites W1965975248 @default.
• W2053204175 cites W1966486441 @default.
• W2053204175 cites W1974821002 @default.
• W2053204175 cites W1981015625 @default.
• W2053204175 cites W1983331741 @default.
• W2053204175 cites W1991551052 @default.
• W2053204175 cites W1999359082 @default.
• W2053204175 cites W2007919709 @default.
• W2053204175 cites W2011733750 @default.
• W2053204175 cites W2011766447 @default.
• W2053204175 cites W2020364709 @default.
• W2053204175 cites W2021728262 @default.
• W2053204175 cites W2027488038 @default.
• W2053204175 cites W2027743842 @default.
• W2053204175 cites W2041109111 @default.
• W2053204175 cites W2043154617 @default.
• W2053204175 cites W2044193679 @default.
• W2053204175 cites W2044795229 @default.
• W2053204175 cites W2050027980 @default.
• W2053204175 cites W2051026900 @default.
• W2053204175 cites W2051875850 @default.
• W2053204175 cites W2053123180 @default.
• W2053204175 cites W2055168506 @default.
• W2053204175 cites W2064358476 @default.
• W2053204175 cites W2085202489 @default.
• W2053204175 cites W2088253384 @default.
• W2053204175 cites W2091851800 @default.
• W2053204175 cites W2114878646 @default.
• W2053204175 cites W2120073050 @default.
• W2053204175 cites W2120598060 @default.
• W2053204175 cites W2125803656 @default.
• W2053204175 cites W2129016986 @default.
• W2053204175 cites W2133163271 @default.
• W2053204175 cites W2136111239 @default.
• W2053204175 cites W2137847399 @default.
• W2053204175 cites W2138441292 @default.
• W2053204175 cites W2145394220 @default.
• W2053204175 cites W2148101123 @default.
• W2053204175 cites W2162551249 @default.
• W2053204175 cites W2165256339 @default.
• W2053204175 cites W2238040093 @default.
• W2053204175 cites W2284031654 @default.
• W2053204175 cites W2299966384 @default.
• W2053204175 cites W2335694423 @default.
• W2053204175 cites W4234433304 @default.
• W2053204175 cites W4248932937 @default.
• W2053204175 cites W4254526461 @default.
• W2053204175 cites W4376595591 @default.
• W2053204175 doi "https://doi.org/10.1080/10739680701436129" @default.
• W2053204175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17885994" @default.
• W2053204175 hasPublicationYear "2007" @default.
• W2053204175 type Work @default.
• W2053204175 sameAs 2053204175 @default.
• W2053204175 citedByCount "9" @default.
• W2053204175 countsByYear W20532041752012 @default.
• W2053204175 countsByYear W20532041752013 @default.
• W2053204175 countsByYear W20532041752018 @default.
• W2053204175 countsByYear W20532041752022 @default.
• W2053204175 crossrefType "journal-article" @default.
• W2053204175 hasAuthorship W2053204175A5022667959 @default.
• W2053204175 hasAuthorship W2053204175A5023058464 @default.
• W2053204175 hasAuthorship W2053204175A5058800719 @default.
• W2053204175 hasAuthorship W2053204175A5090260367 @default.
• W2053204175 hasConcept C113045295 @default.
• W2053204175 hasConcept C11960822 @default.
• W2053204175 hasConcept C120882062 @default.
• W2053204175 hasConcept C126322002 @default.
• W2053204175 hasConcept C134018914 @default.
• W2053204175 hasConcept C147990577 @default.
• W2053204175 hasConcept C150903083 @default.
• W2053204175 hasConcept C161573976 @default.
• W2053204175 hasConcept C17093226 @default.
• W2053204175 hasConcept C185592680 @default.
• W2053204175 hasConcept C195794163 @default.
• W2053204175 hasConcept C207001950 @default.
• W2053204175 hasConcept C2776125364 @default.
• W2053204175 hasConcept C2777866211 @default.
• W2053204175 hasConcept C2779306644 @default.
• W2053204175 hasConcept C41625074 @default.
• W2053204175 hasConcept C55493867 @default.
• W2053204175 hasConcept C555293320 @default.
• W2053204175 hasConcept C71924100 @default.
• W2053204175 hasConcept C86803240 @default.
• W2053204175 hasConceptScore W2053204175C113045295 @default.
• W2053204175 hasConceptScore W2053204175C11960822 @default.
• W2053204175 hasConceptScore W2053204175C120882062 @default.
• W2053204175 hasConceptScore W2053204175C126322002 @default.

• next