FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054295964> ?p ?o ?g. }

• W2054295964 endingPage "691" @default.
• W2054295964 startingPage "683" @default.
• W2054295964 abstract "Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors of the innate immune system that bind peptidoglycans (PGNs) of bacterial cell walls. These molecules, which are highly conserved from insects to mammals, contribute to host defense against infections by both Gram-positive and Gram-negative bacteria. Here, we present the crystal structure of human PGRP-S at 1.70 Å resolution. The overall structure of PGRP-S, which participates in intracellular killing of Gram-positive bacteria, is similar to that of other PGRPs, including Drosophila PGRP-LB and PGRP-SA and human PGRP-Iα. However, comparison with these PGRPs reveals important differences in both the PGN-binding site and a groove formed by the PGRP-specific segment on the opposite face of the molecule. This groove, which may constitute a binding site for effector or signaling proteins, is less hydrophobic and deeper in PGRP-S than in PGRP-IαC, whose PGRP-specific segments vary considerably in amino acid sequence. By docking a PGN ligand into the PGN-binding cleft of PGRP-S based on the known structure of a PGRP-Iα–PGN complex, we identified potential PGN-binding residues in PGRP-S. Differences in PGN-contacting residues and interactions suggest that, although PGRPs may engage PGNs in a similar mode, structural differences exist that likely regulate the affinity and fine specificity of PGN recognition." @default.
• W2054295964 created "2016-06-24" @default.
• W2054295964 creator A5037693404 @default.
• W2054295964 creator A5046225712 @default.
• W2054295964 creator A5055847878 @default.
• W2054295964 creator A5086866774 @default.
• W2054295964 date "2005-04-01" @default.
• W2054295964 modified "2023-09-25" @default.
• W2054295964 title "Crystal Structure of Human Peptidoglycan Recognition Protein S (PGRP-S) at 1.70Å Resolution" @default.
• W2054295964 cites W1514224413 @default.
• W2054295964 cites W1970190307 @default.
• W2054295964 cites W1972053181 @default.
• W2054295964 cites W1980927664 @default.
• W2054295964 cites W1985241441 @default.
• W2054295964 cites W1985629904 @default.
• W2054295964 cites W1991894986 @default.
• W2054295964 cites W1993037429 @default.
• W2054295964 cites W1994599007 @default.
• W2054295964 cites W1995017064 @default.
• W2054295964 cites W2000530029 @default.
• W2054295964 cites W2000667679 @default.
• W2054295964 cites W2002225831 @default.
• W2054295964 cites W2004732995 @default.
• W2054295964 cites W2006768051 @default.
• W2054295964 cites W2016143376 @default.
• W2054295964 cites W2020664730 @default.
• W2054295964 cites W2024974737 @default.
• W2054295964 cites W2028231353 @default.
• W2054295964 cites W2029845836 @default.
• W2054295964 cites W2033368676 @default.
• W2054295964 cites W2036755790 @default.
• W2054295964 cites W2038840577 @default.
• W2054295964 cites W2045404157 @default.
• W2054295964 cites W2047549277 @default.
• W2054295964 cites W2059145665 @default.
• W2054295964 cites W2074636100 @default.
• W2054295964 cites W2079825884 @default.
• W2054295964 cites W2080476827 @default.
• W2054295964 cites W2080528351 @default.
• W2054295964 cites W2084575458 @default.
• W2054295964 cites W2089034514 @default.
• W2054295964 cites W2097042447 @default.
• W2054295964 cites W2106315897 @default.
• W2054295964 cites W2106882534 @default.
• W2054295964 cites W2116947993 @default.
• W2054295964 cites W2124786856 @default.
• W2054295964 cites W2125912444 @default.
• W2054295964 cites W2128584517 @default.
• W2054295964 cites W2134976486 @default.
• W2054295964 cites W2135839939 @default.
• W2054295964 cites W2136986799 @default.
• W2054295964 cites W2140289284 @default.
• W2054295964 cites W2150771431 @default.
• W2054295964 cites W2152457344 @default.
• W2054295964 doi "https://doi.org/10.1016/j.jmb.2005.01.070" @default.
• W2054295964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15769462" @default.
• W2054295964 hasPublicationYear "2005" @default.
• W2054295964 type Work @default.
• W2054295964 sameAs 2054295964 @default.
• W2054295964 citedByCount "77" @default.
• W2054295964 countsByYear W20542959642012 @default.
• W2054295964 countsByYear W20542959642013 @default.
• W2054295964 countsByYear W20542959642014 @default.
• W2054295964 countsByYear W20542959642015 @default.
• W2054295964 countsByYear W20542959642016 @default.
• W2054295964 countsByYear W20542959642017 @default.
• W2054295964 countsByYear W20542959642018 @default.
• W2054295964 countsByYear W20542959642019 @default.
• W2054295964 countsByYear W20542959642020 @default.
• W2054295964 countsByYear W20542959642021 @default.
• W2054295964 countsByYear W20542959642022 @default.
• W2054295964 countsByYear W20542959642023 @default.
• W2054295964 crossrefType "journal-article" @default.
• W2054295964 hasAuthorship W2054295964A5037693404 @default.
• W2054295964 hasAuthorship W2054295964A5046225712 @default.
• W2054295964 hasAuthorship W2054295964A5055847878 @default.
• W2054295964 hasAuthorship W2054295964A5086866774 @default.
• W2054295964 hasConcept C104317684 @default.
• W2054295964 hasConcept C107824862 @default.
• W2054295964 hasConcept C111289621 @default.
• W2054295964 hasConcept C125235067 @default.
• W2054295964 hasConcept C136449434 @default.
• W2054295964 hasConcept C167625842 @default.
• W2054295964 hasConcept C170493617 @default.
• W2054295964 hasConcept C2776634448 @default.
• W2054295964 hasConcept C55493867 @default.
• W2054295964 hasConcept C86803240 @default.
• W2054295964 hasConceptScore W2054295964C104317684 @default.
• W2054295964 hasConceptScore W2054295964C107824862 @default.
• W2054295964 hasConceptScore W2054295964C111289621 @default.
• W2054295964 hasConceptScore W2054295964C125235067 @default.
• W2054295964 hasConceptScore W2054295964C136449434 @default.
• W2054295964 hasConceptScore W2054295964C167625842 @default.
• W2054295964 hasConceptScore W2054295964C170493617 @default.
• W2054295964 hasConceptScore W2054295964C2776634448 @default.
• W2054295964 hasConceptScore W2054295964C55493867 @default.
• W2054295964 hasConceptScore W2054295964C86803240 @default.
• W2054295964 hasIssue "4" @default.

• next