Matches in SemOpenAlex for { <https://semopenalex.org/work/W2054409862> ?p ?o ?g. }
- W2054409862 endingPage "e52949" @default.
- W2054409862 startingPage "e52949" @default.
- W2054409862 abstract "Identification of thymocyte regulators is a central issue in T cell biology. Interestingly, growing evidence indicates that common key molecules control neuronal and immune cell functions. The neurotrophic factor receptor RET mediates critical functions in foetal hematopoietic subsets, thus raising the possibility that RET-related molecules may also control T cell development. We show that Ret, Gfra1 and Gfra2 are abundantly expressed by foetal and adult immature DN thymocytes. Despite the developmentally regulated expression of these genes, analysis of foetal thymi from Gfra1, Gfra2 or Ret deficient embryos revealed that these molecules are dispensable for foetal T cell development. Furthermore, analysis of RET gain of function and Ret conditional knockout mice showed that RET is also unnecessary for adult thymopoiesis. Finally, competitive thymic reconstitution assays indicated that Ret deficient thymocytes maintained their differentiation fitness even in stringent developmental conditions. Thus, our data demonstrate that RET/GFRα signals are dispensable for thymic T cell development in vivo, indicating that pharmacological targeting of RET signalling in tumours is not likely to result in T cell production failure." @default.
- W2054409862 created "2016-06-24" @default.
- W2054409862 creator A5011193891 @default.
- W2054409862 creator A5012592108 @default.
- W2054409862 creator A5028109392 @default.
- W2054409862 creator A5029598354 @default.
- W2054409862 creator A5044438820 @default.
- W2054409862 creator A5061875212 @default.
- W2054409862 creator A5082747006 @default.
- W2054409862 date "2012-12-27" @default.
- W2054409862 modified "2023-10-16" @default.
- W2054409862 title "RET/GFRα Signals Are Dispensable for Thymic T Cell Development In Vivo" @default.
- W2054409862 cites W1590048328 @default.
- W2054409862 cites W1671274164 @default.
- W2054409862 cites W1775427038 @default.
- W2054409862 cites W1931461170 @default.
- W2054409862 cites W1968517866 @default.
- W2054409862 cites W1968627142 @default.
- W2054409862 cites W1971208141 @default.
- W2054409862 cites W1974305953 @default.
- W2054409862 cites W1980026279 @default.
- W2054409862 cites W1987566228 @default.
- W2054409862 cites W1990541262 @default.
- W2054409862 cites W2002817805 @default.
- W2054409862 cites W2005029096 @default.
- W2054409862 cites W2009259931 @default.
- W2054409862 cites W2023566060 @default.
- W2054409862 cites W2024488862 @default.
- W2054409862 cites W2036834043 @default.
- W2054409862 cites W2038304451 @default.
- W2054409862 cites W2040664117 @default.
- W2054409862 cites W2064068457 @default.
- W2054409862 cites W2068558245 @default.
- W2054409862 cites W2086829762 @default.
- W2054409862 cites W2090061589 @default.
- W2054409862 cites W2095652211 @default.
- W2054409862 cites W2099130754 @default.
- W2054409862 cites W2104207674 @default.
- W2054409862 cites W2104602493 @default.
- W2054409862 cites W2108715505 @default.
- W2054409862 cites W2119501407 @default.
- W2054409862 cites W2124386542 @default.
- W2054409862 cites W2134705919 @default.
- W2054409862 cites W2140489687 @default.
- W2054409862 cites W2148773736 @default.
- W2054409862 cites W2150094887 @default.
- W2054409862 cites W2161704465 @default.
- W2054409862 doi "https://doi.org/10.1371/journal.pone.0052949" @default.
- W2054409862 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3531415" @default.
- W2054409862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23300832" @default.
- W2054409862 hasPublicationYear "2012" @default.
- W2054409862 type Work @default.
- W2054409862 sameAs 2054409862 @default.
- W2054409862 citedByCount "16" @default.
- W2054409862 countsByYear W20544098622014 @default.
- W2054409862 countsByYear W20544098622015 @default.
- W2054409862 countsByYear W20544098622016 @default.
- W2054409862 countsByYear W20544098622017 @default.
- W2054409862 countsByYear W20544098622019 @default.
- W2054409862 countsByYear W20544098622020 @default.
- W2054409862 countsByYear W20544098622021 @default.
- W2054409862 countsByYear W20544098622022 @default.
- W2054409862 crossrefType "journal-article" @default.
- W2054409862 hasAuthorship W2054409862A5011193891 @default.
- W2054409862 hasAuthorship W2054409862A5012592108 @default.
- W2054409862 hasAuthorship W2054409862A5028109392 @default.
- W2054409862 hasAuthorship W2054409862A5029598354 @default.
- W2054409862 hasAuthorship W2054409862A5044438820 @default.
- W2054409862 hasAuthorship W2054409862A5061875212 @default.
- W2054409862 hasAuthorship W2054409862A5082747006 @default.
- W2054409862 hasBestOaLocation W20544098621 @default.
- W2054409862 hasConcept C104317684 @default.
- W2054409862 hasConcept C170493617 @default.
- W2054409862 hasConcept C203014093 @default.
- W2054409862 hasConcept C207001950 @default.
- W2054409862 hasConcept C2776090121 @default.
- W2054409862 hasConcept C2778954852 @default.
- W2054409862 hasConcept C502942594 @default.
- W2054409862 hasConcept C54355233 @default.
- W2054409862 hasConcept C62112901 @default.
- W2054409862 hasConcept C86339819 @default.
- W2054409862 hasConcept C86803240 @default.
- W2054409862 hasConcept C8891405 @default.
- W2054409862 hasConcept C95444343 @default.
- W2054409862 hasConceptScore W2054409862C104317684 @default.
- W2054409862 hasConceptScore W2054409862C170493617 @default.
- W2054409862 hasConceptScore W2054409862C203014093 @default.
- W2054409862 hasConceptScore W2054409862C207001950 @default.
- W2054409862 hasConceptScore W2054409862C2776090121 @default.
- W2054409862 hasConceptScore W2054409862C2778954852 @default.
- W2054409862 hasConceptScore W2054409862C502942594 @default.
- W2054409862 hasConceptScore W2054409862C54355233 @default.
- W2054409862 hasConceptScore W2054409862C62112901 @default.
- W2054409862 hasConceptScore W2054409862C86339819 @default.
- W2054409862 hasConceptScore W2054409862C86803240 @default.
- W2054409862 hasConceptScore W2054409862C8891405 @default.
- W2054409862 hasConceptScore W2054409862C95444343 @default.
- W2054409862 hasIssue "12" @default.