FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056282994> ?p ?o ?g. }

• W2056282994 endingPage "F882" @default.
• W2056282994 startingPage "F870" @default.
• W2056282994 abstract "Macrophages are heterogeneous immune cell populations that include classically activated and alternatively activated (M2) macrophages. We examined the anti-inflammatory effect of ANG II type 1 receptor (AT(1)R) blocker (ARB) on glomerular inflammation in a rat model of anti-glomerular basement membrane (GBM) glomerulonephritis (GN). The study focused on infiltrating CD8(+) and CD4(+) cells and macrophages, as well as the heterogeneity of intraglomerular macrophages. Wistar-Kyoto rats were treated with high-dose olmesartan (3 mg.kg(-1).day(-1)), low-dose olmesartan (0.3 mg.kg(-1).day(-1)), or vehicle (control) 7 days before induction of anti-GBM GN. Control rats showed mainly CD8(+) cells and ED1(+) macrophages, with a few CD4(+) cells infiltrating the glomeruli. Necrotizing and crescentic glomerular lesions developed by day 7 with the increase of proteinuria. AT(1)R was expressed on CD8(+) and CD4(+) cells and on ED1(+) macrophages. Low-dose ARB had no anti-inflammatory effects in anti-GBM GN. However, high-dose ARB reduced glomerular infiltration of CD8(+) cells and ED1(+) macrophages and suppressed necrotizing and crescentic lesions by days 5 to 7 (P < 0.05). In addition, high-dose ARB reduced the numbers of ED3(+)-activated macrophages, suppressed glomerular TNF-alpha and IFN-gamma production, and downregulated M1-related chemokine and cytokines (monocyte chemoattractant protein type 1, IL-6, and IL-12). High-dose ARB also enhanced ED2(+) M2 macrophages by day 7 with upregulation of glomerular IL-4 and IL-13 and augmented CCL17, IL-1 receptor antagonist, and IL-10. We concluded that high-dose ARB inhibits glomerular inflammation by increasing the numbers of M2 macrophages and upregulation of anti-inflammatory cytokines and by suppressing M1 macrophage development with downregulation of M1-related proinflammatory cytokines." @default.
• W2056282994 created "2016-06-24" @default.
• W2056282994 creator A5000347486 @default.
• W2056282994 creator A5006179653 @default.
• W2056282994 creator A5025183664 @default.
• W2056282994 creator A5034292099 @default.
• W2056282994 creator A5037766371 @default.
• W2056282994 creator A5046829573 @default.
• W2056282994 creator A5048576534 @default.
• W2056282994 creator A5066816389 @default.
• W2056282994 creator A5069135642 @default.
• W2056282994 creator A5070798513 @default.
• W2056282994 creator A5085358834 @default.
• W2056282994 date "2010-04-01" @default.
• W2056282994 modified "2023-10-18" @default.
• W2056282994 title "ANG II receptor blockade enhances anti-inflammatory macrophages in anti-glomerular basement membrane glomerulonephritis" @default.
• W2056282994 cites W1583446759 @default.
• W2056282994 cites W1592720347 @default.
• W2056282994 cites W1988742278 @default.
• W2056282994 cites W2000128077 @default.
• W2056282994 cites W2006719896 @default.
• W2056282994 cites W2009170266 @default.
• W2056282994 cites W2016293419 @default.
• W2056282994 cites W2017261910 @default.
• W2056282994 cites W2019767570 @default.
• W2056282994 cites W2020744745 @default.
• W2056282994 cites W2021232559 @default.
• W2056282994 cites W2021336399 @default.
• W2056282994 cites W2021345753 @default.
• W2056282994 cites W2026849698 @default.
• W2056282994 cites W2036960544 @default.
• W2056282994 cites W2038689279 @default.
• W2056282994 cites W2039803851 @default.
• W2056282994 cites W2048894509 @default.
• W2056282994 cites W2051921347 @default.
• W2056282994 cites W2053180390 @default.
• W2056282994 cites W2054472394 @default.
• W2056282994 cites W2055808591 @default.
• W2056282994 cites W2058081546 @default.
• W2056282994 cites W2058422032 @default.
• W2056282994 cites W2059316697 @default.
• W2056282994 cites W2064732202 @default.
• W2056282994 cites W2069218148 @default.
• W2056282994 cites W2075604884 @default.
• W2056282994 cites W2085701175 @default.
• W2056282994 cites W2086985783 @default.
• W2056282994 cites W2091433468 @default.
• W2056282994 cites W2093705034 @default.
• W2056282994 cites W2095400574 @default.
• W2056282994 cites W2097334774 @default.
• W2056282994 cites W2097805169 @default.
• W2056282994 cites W2103394009 @default.
• W2056282994 cites W2104388295 @default.
• W2056282994 cites W2123640179 @default.
• W2056282994 cites W2127336805 @default.
• W2056282994 cites W2135016519 @default.
• W2056282994 cites W2139275890 @default.
• W2056282994 cites W2148103781 @default.
• W2056282994 cites W2149116434 @default.
• W2056282994 cites W2156885256 @default.
• W2056282994 cites W2158530794 @default.
• W2056282994 cites W2160316947 @default.
• W2056282994 cites W2164096901 @default.
• W2056282994 cites W2313030564 @default.
• W2056282994 cites W3145527833 @default.
• W2056282994 doi "https://doi.org/10.1152/ajprenal.00374.2009" @default.
• W2056282994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20071465" @default.
• W2056282994 hasPublicationYear "2010" @default.
• W2056282994 type Work @default.
• W2056282994 sameAs 2056282994 @default.
• W2056282994 citedByCount "59" @default.
• W2056282994 countsByYear W20562829942012 @default.
• W2056282994 countsByYear W20562829942013 @default.
• W2056282994 countsByYear W20562829942014 @default.
• W2056282994 countsByYear W20562829942015 @default.
• W2056282994 countsByYear W20562829942016 @default.
• W2056282994 countsByYear W20562829942017 @default.
• W2056282994 countsByYear W20562829942018 @default.
• W2056282994 countsByYear W20562829942019 @default.
• W2056282994 countsByYear W20562829942020 @default.
• W2056282994 countsByYear W20562829942021 @default.
• W2056282994 countsByYear W20562829942022 @default.
• W2056282994 crossrefType "journal-article" @default.
• W2056282994 hasAuthorship W2056282994A5000347486 @default.
• W2056282994 hasAuthorship W2056282994A5006179653 @default.
• W2056282994 hasAuthorship W2056282994A5025183664 @default.
• W2056282994 hasAuthorship W2056282994A5034292099 @default.
• W2056282994 hasAuthorship W2056282994A5037766371 @default.
• W2056282994 hasAuthorship W2056282994A5046829573 @default.
• W2056282994 hasAuthorship W2056282994A5048576534 @default.
• W2056282994 hasAuthorship W2056282994A5066816389 @default.
• W2056282994 hasAuthorship W2056282994A5069135642 @default.
• W2056282994 hasAuthorship W2056282994A5070798513 @default.
• W2056282994 hasAuthorship W2056282994A5085358834 @default.
• W2056282994 hasConcept C126322002 @default.
• W2056282994 hasConcept C13373296 @default.
• W2056282994 hasConcept C134018914 @default.
• W2056282994 hasConcept C167672396 @default.

• next