FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2056558538> ?p ?o ?g. }

• W2056558538 abstract "This study was conducted to reassess the concepts established over the past 20 years, in particular in the last 5 years, about the use of methylene blue in the treatment of vasoplegic syndrome in cardiac surgery.A wide literature review was carried out using the data extracted from: MEDLINE, SCOPUS and ISI WEB OF SCIENCE.The reassessed and reaffirmed concepts were 1) MB is safe in the recommended doses (the lethal dose is 40 mg/kg); 2) MB does not cause endothelial dysfunction; 3) The MB effect appears in cases of NO up-regulation; 4) MB is not a vasoconstrictor, by blocking the cGMP pathway it releases the cAMP pathway, facilitating the norepinephrine vasoconstrictor effect; 5) The most used dosage is 2 mg/kg as IV bolus, followed by the same continuous infusion because plasma concentrations sharply decrease in the first 40 minutes; and 6) There is a possible window of opportunity for MB's effectiveness. In the last five years, major challenges were: 1) Observations about side effects; 2) The need for prophylactic and therapeutic guidelines, and; 3) The need for the establishment of the MB therapeutic window in humans.MB action to treat vasoplegic syndrome is time-dependent. Therefore, the great challenge is the need, for the establishment the MB therapeutic window in humans. This would be the first step towards a systematic guideline to be followed by possible multicenter studies." @default.
• W2056558538 created "2016-06-24" @default.
• W2056558538 creator A5014363434 @default.
• W2056558538 creator A5017443224 @default.
• W2056558538 creator A5026021015 @default.
• W2056558538 creator A5027188226 @default.
• W2056558538 creator A5032615914 @default.
• W2056558538 creator A5035538885 @default.
• W2056558538 creator A5064261774 @default.
• W2056558538 creator A5085135452 @default.
• W2056558538 date "2014-01-01" @default.
• W2056558538 modified "2023-09-23" @default.
• W2056558538 title "Twenty years of vasoplegic syndrome treatment in heart surgery. Methylene blue revised" @default.
• W2056558538 cites W1583262546 @default.
• W2056558538 cites W1965452035 @default.
• W2056558538 cites W1968619747 @default.
• W2056558538 cites W1969223596 @default.
• W2056558538 cites W1974534758 @default.
• W2056558538 cites W1978956926 @default.
• W2056558538 cites W1980259685 @default.
• W2056558538 cites W1981105814 @default.
• W2056558538 cites W1984314982 @default.
• W2056558538 cites W1988717949 @default.
• W2056558538 cites W2004828123 @default.
• W2056558538 cites W2007372190 @default.
• W2056558538 cites W2026885542 @default.
• W2056558538 cites W2028328103 @default.
• W2056558538 cites W2035445095 @default.
• W2056558538 cites W2074131771 @default.
• W2056558538 cites W2075358790 @default.
• W2056558538 cites W2080033762 @default.
• W2056558538 cites W2104171421 @default.
• W2056558538 cites W2108855760 @default.
• W2056558538 cites W2115253821 @default.
• W2056558538 cites W2127159528 @default.
• W2056558538 cites W2145972784 @default.
• W2056558538 cites W2150368942 @default.
• W2056558538 cites W2154589041 @default.
• W2056558538 cites W2154759602 @default.
• W2056558538 cites W2156957717 @default.
• W2056558538 cites W2166641668 @default.
• W2056558538 cites W2246811168 @default.
• W2056558538 cites W2405113269 @default.
• W2056558538 cites W2414179298 @default.
• W2056558538 cites W2418750519 @default.
• W2056558538 doi "https://doi.org/10.5935/1678-9741.20140115" @default.
• W2056558538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4389523" @default.
• W2056558538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25859872" @default.
• W2056558538 hasPublicationYear "2014" @default.
• W2056558538 type Work @default.
• W2056558538 sameAs 2056558538 @default.
• W2056558538 citedByCount "29" @default.
• W2056558538 countsByYear W20565585382015 @default.
• W2056558538 countsByYear W20565585382016 @default.
• W2056558538 countsByYear W20565585382017 @default.
• W2056558538 countsByYear W20565585382018 @default.
• W2056558538 countsByYear W20565585382019 @default.
• W2056558538 countsByYear W20565585382020 @default.
• W2056558538 countsByYear W20565585382021 @default.
• W2056558538 countsByYear W20565585382022 @default.
• W2056558538 countsByYear W20565585382023 @default.
• W2056558538 crossrefType "journal-article" @default.
• W2056558538 hasAuthorship W2056558538A5014363434 @default.
• W2056558538 hasAuthorship W2056558538A5017443224 @default.
• W2056558538 hasAuthorship W2056558538A5026021015 @default.
• W2056558538 hasAuthorship W2056558538A5027188226 @default.
• W2056558538 hasAuthorship W2056558538A5032615914 @default.
• W2056558538 hasAuthorship W2056558538A5035538885 @default.
• W2056558538 hasAuthorship W2056558538A5064261774 @default.
• W2056558538 hasAuthorship W2056558538A5085135452 @default.
• W2056558538 hasBestOaLocation W20565585381 @default.
• W2056558538 hasConcept C126322002 @default.
• W2056558538 hasConcept C141071460 @default.
• W2056558538 hasConcept C142724271 @default.
• W2056558538 hasConcept C161790260 @default.
• W2056558538 hasConcept C177713679 @default.
• W2056558538 hasConcept C185592680 @default.
• W2056558538 hasConcept C2778514916 @default.
• W2056558538 hasConcept C2778789114 @default.
• W2056558538 hasConcept C2779191827 @default.
• W2056558538 hasConcept C2780182762 @default.
• W2056558538 hasConcept C42219234 @default.
• W2056558538 hasConcept C43376680 @default.
• W2056558538 hasConcept C513476851 @default.
• W2056558538 hasConcept C55493867 @default.
• W2056558538 hasConcept C65165184 @default.
• W2056558538 hasConcept C71924100 @default.
• W2056558538 hasConceptScore W2056558538C126322002 @default.
• W2056558538 hasConceptScore W2056558538C141071460 @default.
• W2056558538 hasConceptScore W2056558538C142724271 @default.
• W2056558538 hasConceptScore W2056558538C161790260 @default.
• W2056558538 hasConceptScore W2056558538C177713679 @default.
• W2056558538 hasConceptScore W2056558538C185592680 @default.
• W2056558538 hasConceptScore W2056558538C2778514916 @default.
• W2056558538 hasConceptScore W2056558538C2778789114 @default.
• W2056558538 hasConceptScore W2056558538C2779191827 @default.
• W2056558538 hasConceptScore W2056558538C2780182762 @default.
• W2056558538 hasConceptScore W2056558538C42219234 @default.
• W2056558538 hasConceptScore W2056558538C43376680 @default.
• W2056558538 hasConceptScore W2056558538C513476851 @default.

• next