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• W2056760918 abstract "Alterations in amino acid sequence can generate neo-epitopes from self proteins, causing autoaggressive immune attack. There is a range of possible post-translational modifications (PTMs) of mammalian proteins that can allow immune recognition of neo-self epitopes. These effects can vary from overt increase in affinity of MHC or T-cell receptor binding, to more subtle effects on the activity of proteolytic enzymes involved in antigen processing. Furthermore, intriguing insights into how the complex interactions between inflammation, enzyme activity and protein modification can direct self recognition are beginning to be unearthed." @default.
• W2056760918 created "2016-06-24" @default.
• W2056760918 creator A5048814583 @default.
• W2056760918 date "2004-12-01" @default.
• W2056760918 modified "2023-09-27" @default.
• W2056760918 title "Post-translational modifications of self antigens: implications for autoimmunity" @default.
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• W2056760918 doi "https://doi.org/10.1016/j.coi.2004.09.001" @default.
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