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• W2058164080 abstract "(trans,trans)-Muconaldehyde, a putative metabolite of benzene, should be expected to have mutagenic properties by virtue of its twin alpha,beta-unsaturated carbonylic function. It displayed definitely mutagenic properties in S. typhimurium TA100 without metabolic activation and with a 5-fold concentration of tester organisms in the preincubation assay and induced SOS response in E. coli. It induced micronucleus formation and morphological transformation in a dose-dependent manner in Syrian hamster embryofibroblasts. No DNA single-strand breaks or interstrand cross-links could be detected using the alkaline elution technique; however, strand-break generation by subsequent gamma-irradiation was found to be increased." @default.
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• W2058164080 date "1991-05-01" @default.
• W2058164080 modified "2023-09-27" @default.
• W2058164080 title "Genotoxic and cell-transforming properties of (trans,trans)-muconaldehyde" @default.
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• W2058164080 doi "https://doi.org/10.1016/0027-5107(91)90085-3" @default.
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