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- W2059098736 abstract "The response of an SV40-immortalized hepatocyte cell line (CWSV-1) derived from adult male rat hepatocytes to human growth hormone (hGH) was investigated. CWSV-1 cells, which have been characterized extensively, retain certain differentiated functions of normal liver (Woodworth and Isom, Mol Cell Biol7: 3740–3748, 1987). This cell line consists of tightly associated polygonal, mononucleated cells that grow as monolayers. These cells showed no significant morphological changes with the addition of hGH. Northern blot analysis showed that continuous treatment of the CWSV-1 cells with hGH induced the expression of insulin-like growth factor I (IGF-I) and 5α-reductase RNAs. In addition, continuous exposure to hGH resulted in the induction of expression of the growth hormone receptor/growth hormone binding protein (GHR/GHBP) genes. This study indicates that the CWSV-1 cells may serve as a valuable in vitro model system for studying the signaling pathway of GH." @default.
- W2059098736 created "2016-06-24" @default.
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- W2059098736 date "1995-04-01" @default.
- W2059098736 modified "2023-09-24" @default.
- W2059098736 title "Responsiveness of an SV40-immortalized hepatocyte cell line to growth hormone" @default.
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- W2059098736 doi "https://doi.org/10.1016/0006-2952(95)98506-5" @default.
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