FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059338890> ?p ?o ?g. }

• W2059338890 endingPage "509" @default.
• W2059338890 startingPage "503" @default.
• W2059338890 abstract "The effects of SD‐3212 on transmembrane action potentials were examined in right ventricular papillary muscles and in single ventricular myocytes isolated from guinea‐pig hearts. In papillary muscles, SD‐3212 ≥ 3 μ m caused a significant decrease in the maximum upstroke velocity () of action potential without affecting resting membrane potential. The inhibition of was enhanced at higher stimulation frequencies. In the presence of SD‐3212, trains of stimuli at rates ≥ 0.5 Hz led to a use‐dependent inhibition of . The time constant for the recovery of from the use‐dependent block was 1.3 s. Voltage‐dependence of inhibition by SD‐3212 was investigated in single myocytes. The curves relating membrane potential and were shifted by SD‐3212 (10 μ m ) in a hyperpolarizing direction by 6.2 mV. In myocytes treated with SD‐3212 (10 μ m ), the of test action potentials preceded by conditioning clamp to 0 mV was decreased progressively as the clamp pulse duration was prolonged. of test action potentials following a long (1 s) 0 mV clamp recovered at a time constant ranging from 1.01 to 1.22 s, being shorter at the more negative potential within a range from −70 to −90 mV. These findings suggest that the primary electrophysiological effect of SD‐3212 is a use‐ and voltage‐dependent inhibition of sodium channels. From the onset and offset kinetics of the use‐dependent block, SD‐3212 is located between fast and intermediate kinetic Class‐I drugs. From the state‐dependence of sodium channel block, SD‐3212 belongs to inactivated channel blockers." @default.
• W2059338890 created "2016-06-24" @default.
• W2059338890 creator A5004782576 @default.
• W2059338890 creator A5024500340 @default.
• W2059338890 creator A5068242812 @default.
• W2059338890 creator A5079500797 @default.
• W2059338890 date "1995-01-01" @default.
• W2059338890 modified "2023-10-18" @default.
• W2059338890 title "Electrophysiological effects of SD-3212, a new antiarrhythmic agent with vasodilator action, on guinea-pig ventricular cells" @default.
• W2059338890 cites W1956357205 @default.
• W2059338890 cites W1972081273 @default.
• W2059338890 cites W1992353595 @default.
• W2059338890 cites W2002594172 @default.
• W2059338890 cites W2021639214 @default.
• W2059338890 cites W2025148785 @default.
• W2059338890 cites W2028167410 @default.
• W2059338890 cites W2032655162 @default.
• W2059338890 cites W2048002464 @default.
• W2059338890 cites W2050823348 @default.
• W2059338890 cites W2059796887 @default.
• W2059338890 cites W2060366195 @default.
• W2059338890 cites W2061595273 @default.
• W2059338890 cites W2063090222 @default.
• W2059338890 cites W2068782647 @default.
• W2059338890 cites W2069884282 @default.
• W2059338890 cites W2075993474 @default.
• W2059338890 cites W2084603593 @default.
• W2059338890 cites W2095587732 @default.
• W2059338890 cites W2126997063 @default.
• W2059338890 cites W2155932859 @default.
• W2059338890 cites W2162277138 @default.
• W2059338890 cites W2278171826 @default.
• W2059338890 cites W2394528711 @default.
• W2059338890 doi "https://doi.org/10.1111/j.1476-5381.1995.tb13255.x" @default.
• W2059338890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1510254" @default.
• W2059338890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7881749" @default.
• W2059338890 hasPublicationYear "1995" @default.
• W2059338890 type Work @default.
• W2059338890 sameAs 2059338890 @default.
• W2059338890 citedByCount "15" @default.
• W2059338890 countsByYear W20593388902013 @default.
• W2059338890 countsByYear W20593388902014 @default.
• W2059338890 countsByYear W20593388902016 @default.
• W2059338890 crossrefType "journal-article" @default.
• W2059338890 hasAuthorship W2059338890A5004782576 @default.
• W2059338890 hasAuthorship W2059338890A5024500340 @default.
• W2059338890 hasAuthorship W2059338890A5068242812 @default.
• W2059338890 hasAuthorship W2059338890A5079500797 @default.
• W2059338890 hasBestOaLocation W20593388902 @default.
• W2059338890 hasConcept C100837961 @default.
• W2059338890 hasConcept C12554922 @default.
• W2059338890 hasConcept C126322002 @default.
• W2059338890 hasConcept C146403970 @default.
• W2059338890 hasConcept C147944092 @default.
• W2059338890 hasConcept C158494493 @default.
• W2059338890 hasConcept C178790620 @default.
• W2059338890 hasConcept C181911157 @default.
• W2059338890 hasConcept C185263204 @default.
• W2059338890 hasConcept C185592680 @default.
• W2059338890 hasConcept C2778131192 @default.
• W2059338890 hasConcept C2780074459 @default.
• W2059338890 hasConcept C42219234 @default.
• W2059338890 hasConcept C47423411 @default.
• W2059338890 hasConcept C50952357 @default.
• W2059338890 hasConcept C537181965 @default.
• W2059338890 hasConcept C55493867 @default.
• W2059338890 hasConcept C71924100 @default.
• W2059338890 hasConcept C86803240 @default.
• W2059338890 hasConcept C98274493 @default.
• W2059338890 hasConceptScore W2059338890C100837961 @default.
• W2059338890 hasConceptScore W2059338890C12554922 @default.
• W2059338890 hasConceptScore W2059338890C126322002 @default.
• W2059338890 hasConceptScore W2059338890C146403970 @default.
• W2059338890 hasConceptScore W2059338890C147944092 @default.
• W2059338890 hasConceptScore W2059338890C158494493 @default.
• W2059338890 hasConceptScore W2059338890C178790620 @default.
• W2059338890 hasConceptScore W2059338890C181911157 @default.
• W2059338890 hasConceptScore W2059338890C185263204 @default.
• W2059338890 hasConceptScore W2059338890C185592680 @default.
• W2059338890 hasConceptScore W2059338890C2778131192 @default.
• W2059338890 hasConceptScore W2059338890C2780074459 @default.
• W2059338890 hasConceptScore W2059338890C42219234 @default.
• W2059338890 hasConceptScore W2059338890C47423411 @default.
• W2059338890 hasConceptScore W2059338890C50952357 @default.
• W2059338890 hasConceptScore W2059338890C537181965 @default.
• W2059338890 hasConceptScore W2059338890C55493867 @default.
• W2059338890 hasConceptScore W2059338890C71924100 @default.
• W2059338890 hasConceptScore W2059338890C86803240 @default.
• W2059338890 hasConceptScore W2059338890C98274493 @default.
• W2059338890 hasIssue "2" @default.
• W2059338890 hasLocation W20593388901 @default.
• W2059338890 hasLocation W20593388902 @default.
• W2059338890 hasLocation W20593388903 @default.
• W2059338890 hasLocation W20593388904 @default.
• W2059338890 hasOpenAccess W2059338890 @default.
• W2059338890 hasPrimaryLocation W20593388901 @default.
• W2059338890 hasRelatedWork W128018718 @default.
• W2059338890 hasRelatedWork W1482954194 @default.

• next