FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059830147> ?p ?o ?g. }

• W2059830147 endingPage "172" @default.
• W2059830147 startingPage "166" @default.
• W2059830147 abstract "Essential fatty acids (EFA) have been shown in animal studies to have a differential effect on various aspects of immune reactivity. However, there have been few studies in humans. Therefore, we elected to investigate the effects of a variety of EFA [gamma-linolenic acid (GLA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] in vitro on human blood lymphocyte reactivity, cytokine secretion and natural cytotoxicity. The proliferative response to polyclonal mitogens (phytohaemagglutinin, pokeweed mitogen, concanavalin A), as measured by [3H]thymidine incorporation into newly synthesized lymphocytes, was inhibited (P < 0.05) by all EFAs tested, in a dose-dependent manner (3-15 micrograms/ml). The greatest inhibition of proliferation was caused by EPA and DHA. Similarly, EPA, DHA and GLA significantly reduced cytotoxic activity [expressed as lytic units, using 51 chromium-release assays natural killer (NK) (K562 cells) and lymphokine-activated (LAK) (Daudi cells) cells] (P < 0.05) in a concentration-dependent manner (5-50 micrograms/ml), without affecting cell viability. EPA and DHA exhibited greater suppression than GLA. Furthermore, the inhibition of cell proliferation and suppression of natural cytotoxicity was associated with marked decrease in cytokine [interleukin-1 (IL-1), IL-2, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma)] production in vitro. Our findings demonstrate that EFAs (GLA, EPA, DHA) have the potential to inhibit significantly various aspects of human lymphocyte cell-mediated and humoral immune reactivities." @default.
• W2059830147 created "2016-06-24" @default.
• W2059830147 creator A5006031151 @default.
• W2059830147 creator A5026699102 @default.
• W2059830147 creator A5027407323 @default.
• W2059830147 creator A5063555816 @default.
• W2059830147 date "1997-10-01" @default.
• W2059830147 modified "2023-09-27" @default.
• W2059830147 title "Modulation <i>in vitro</i> of human natural cytotoxicity, lymphocyte proliferative response to mitogens and cytokine production by essential fatty acids" @default.
• W2059830147 cites W13275948 @default.
• W2059830147 cites W1480708545 @default.
• W2059830147 cites W1546214748 @default.
• W2059830147 cites W1550885672 @default.
• W2059830147 cites W1571681582 @default.
• W2059830147 cites W1747452239 @default.
• W2059830147 cites W1763490035 @default.
• W2059830147 cites W1848552725 @default.
• W2059830147 cites W186629198 @default.
• W2059830147 cites W1905885236 @default.
• W2059830147 cites W1907854530 @default.
• W2059830147 cites W1911021899 @default.
• W2059830147 cites W1942750313 @default.
• W2059830147 cites W1970032063 @default.
• W2059830147 cites W1976849443 @default.
• W2059830147 cites W1988672861 @default.
• W2059830147 cites W1990487867 @default.
• W2059830147 cites W1995232506 @default.
• W2059830147 cites W1995585950 @default.
• W2059830147 cites W2003938316 @default.
• W2059830147 cites W2040788523 @default.
• W2059830147 cites W2045603262 @default.
• W2059830147 cites W2052469649 @default.
• W2059830147 cites W2053912404 @default.
• W2059830147 cites W2059169426 @default.
• W2059830147 cites W2059576949 @default.
• W2059830147 cites W2078744527 @default.
• W2059830147 cites W2094483802 @default.
• W2059830147 cites W2106928217 @default.
• W2059830147 cites W2153784269 @default.
• W2059830147 cites W2174505927 @default.
• W2059830147 cites W2287324627 @default.
• W2059830147 cites W2304749351 @default.
• W2059830147 cites W2321334948 @default.
• W2059830147 cites W2322553446 @default.
• W2059830147 cites W2327515496 @default.
• W2059830147 cites W2342149952 @default.
• W2059830147 cites W2396568654 @default.
• W2059830147 cites W2435318668 @default.
• W2059830147 cites W4238714531 @default.
• W2059830147 doi "https://doi.org/10.1046/j.1365-2567.1997.d01-2308.x" @default.
• W2059830147 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1364054" @default.
• W2059830147 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9415022" @default.
• W2059830147 hasPublicationYear "1997" @default.
• W2059830147 type Work @default.
• W2059830147 sameAs 2059830147 @default.
• W2059830147 citedByCount "101" @default.
• W2059830147 countsByYear W20598301472012 @default.
• W2059830147 countsByYear W20598301472013 @default.
• W2059830147 countsByYear W20598301472014 @default.
• W2059830147 countsByYear W20598301472015 @default.
• W2059830147 countsByYear W20598301472016 @default.
• W2059830147 countsByYear W20598301472017 @default.
• W2059830147 countsByYear W20598301472018 @default.
• W2059830147 countsByYear W20598301472019 @default.
• W2059830147 countsByYear W20598301472020 @default.
• W2059830147 countsByYear W20598301472021 @default.
• W2059830147 countsByYear W20598301472022 @default.
• W2059830147 crossrefType "journal-article" @default.
• W2059830147 hasAuthorship W2059830147A5006031151 @default.
• W2059830147 hasAuthorship W2059830147A5026699102 @default.
• W2059830147 hasAuthorship W2059830147A5027407323 @default.
• W2059830147 hasAuthorship W2059830147A5063555816 @default.
• W2059830147 hasBestOaLocation W20598301472 @default.
• W2059830147 hasConcept C109316439 @default.
• W2059830147 hasConcept C153911025 @default.
• W2059830147 hasConcept C19038510 @default.
• W2059830147 hasConcept C19869320 @default.
• W2059830147 hasConcept C202751555 @default.
• W2059830147 hasConcept C203014093 @default.
• W2059830147 hasConcept C2777171753 @default.
• W2059830147 hasConcept C2777371288 @default.
• W2059830147 hasConcept C2777761686 @default.
• W2059830147 hasConcept C2778690821 @default.
• W2059830147 hasConcept C2780050583 @default.
• W2059830147 hasConcept C2781005381 @default.
• W2059830147 hasConcept C49382859 @default.
• W2059830147 hasConcept C543025807 @default.
• W2059830147 hasConcept C55493867 @default.
• W2059830147 hasConcept C86803240 @default.
• W2059830147 hasConcept C8891405 @default.
• W2059830147 hasConceptScore W2059830147C109316439 @default.
• W2059830147 hasConceptScore W2059830147C153911025 @default.
• W2059830147 hasConceptScore W2059830147C19038510 @default.
• W2059830147 hasConceptScore W2059830147C19869320 @default.
• W2059830147 hasConceptScore W2059830147C202751555 @default.
• W2059830147 hasConceptScore W2059830147C203014093 @default.
• W2059830147 hasConceptScore W2059830147C2777171753 @default.
• W2059830147 hasConceptScore W2059830147C2777371288 @default.

• next