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- W205999725 abstract "In this review the actions of a range of aminopyridine-like compounds are described on electrically excitable membranes, on the central nervous system, on neuromuscular transmission at skeletal muscle, on parasympathetic and sympathetic neuroeffector transmission and on cardiac muscle. Particular attention is paid to effects on electrically excitable membranes where the prime action of the drugs i.e. inhibition of potassium conductance, may be measured, and on neuromuscular transmission, which is the site of action of the drugs that has been exploited clinically. Examination of chemical structure and properties of a range of compounds indicates that several features are involved in their action, including lipid solubility which may determine access to sites of action, degree of ionization and nature of substituents on the pyridine nucleus which may determine affinity for sites of action." @default.
- W205999725 created "2016-06-24" @default.
- W205999725 creator A5055236752 @default.
- W205999725 date "1982-01-01" @default.
- W205999725 modified "2023-09-26" @default.
- W205999725 title "Structure - Activity Relationships Amongst Aminopyridines" @default.
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- W205999725 doi "https://doi.org/10.1016/b978-0-08-028000-4.50019-1" @default.
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