FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2060129186> ?p ?o ?g. }

• W2060129186 endingPage "744" @default.
• W2060129186 startingPage "731" @default.
• W2060129186 abstract "Autophagy is a catabolic process that ensures homeostatic cell clearance and is deregulated in a growing number of myopathological conditions. Although FoxO3 was shown to promote the expression of autophagy-related genes in skeletal muscle, the mechanisms triggering autophagy are unclear. We show that TSC1-deficient mice (TSCmKO), characterized by sustained activation of mTORC1, develop a late-onset myopathy related to impaired autophagy. In young TSCmKO mice, constitutive and starvation-induced autophagy is blocked at the induction steps via mTORC1-mediated inhibition of Ulk1, despite FoxO3 activation. Rapamycin is sufficient to restore autophagy in TSCmKO mice and improves the muscle phenotype of old mutant mice. Inversely, abrogation of mTORC1 signaling by depletion of raptor induces autophagy regardless of FoxO inhibition. Thus, mTORC1 is the dominant regulator of autophagy induction in skeletal muscle and ensures a tight coordination of metabolic pathways. These findings may open interesting avenues for therapeutic strategies directed toward autophagy-related muscle diseases." @default.
• W2060129186 created "2016-06-24" @default.
• W2060129186 creator A5001808516 @default.
• W2060129186 creator A5024446602 @default.
• W2060129186 creator A5027097638 @default.
• W2060129186 creator A5048376181 @default.
• W2060129186 creator A5055873476 @default.
• W2060129186 creator A5055939605 @default.
• W2060129186 creator A5066296167 @default.
• W2060129186 creator A5086787191 @default.
• W2060129186 creator A5088659624 @default.
• W2060129186 creator A5091877145 @default.
• W2060129186 date "2013-05-01" @default.
• W2060129186 modified "2023-10-14" @default.
• W2060129186 title "Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy" @default.
• W2060129186 cites W1586159393 @default.
• W2060129186 cites W1965470471 @default.
• W2060129186 cites W1967865726 @default.
• W2060129186 cites W1970637701 @default.
• W2060129186 cites W1981141119 @default.
• W2060129186 cites W1994823455 @default.
• W2060129186 cites W1996735611 @default.
• W2060129186 cites W2000731858 @default.
• W2060129186 cites W2016815316 @default.
• W2060129186 cites W2025139842 @default.
• W2060129186 cites W2025192214 @default.
• W2060129186 cites W2027785297 @default.
• W2060129186 cites W2036787961 @default.
• W2060129186 cites W2036901614 @default.
• W2060129186 cites W2048376025 @default.
• W2060129186 cites W2054998824 @default.
• W2060129186 cites W2056137479 @default.
• W2060129186 cites W2059055543 @default.
• W2060129186 cites W2060792177 @default.
• W2060129186 cites W2071221374 @default.
• W2060129186 cites W2093818337 @default.
• W2060129186 cites W2107283445 @default.
• W2060129186 cites W2108360575 @default.
• W2060129186 cites W2108930270 @default.
• W2060129186 cites W2109263914 @default.
• W2060129186 cites W2115742671 @default.
• W2060129186 cites W2116551193 @default.
• W2060129186 cites W2119979409 @default.
• W2060129186 cites W2127063807 @default.
• W2060129186 cites W2128677681 @default.
• W2060129186 cites W2148625376 @default.
• W2060129186 cites W2149451793 @default.
• W2060129186 cites W2159796957 @default.
• W2060129186 cites W2164778558 @default.
• W2060129186 cites W4231548689 @default.
• W2060129186 doi "https://doi.org/10.1016/j.cmet.2013.03.015" @default.
• W2060129186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23602450" @default.
• W2060129186 hasPublicationYear "2013" @default.
• W2060129186 type Work @default.
• W2060129186 sameAs 2060129186 @default.
• W2060129186 citedByCount "210" @default.
• W2060129186 countsByYear W20601291862013 @default.
• W2060129186 countsByYear W20601291862014 @default.
• W2060129186 countsByYear W20601291862015 @default.
• W2060129186 countsByYear W20601291862016 @default.
• W2060129186 countsByYear W20601291862017 @default.
• W2060129186 countsByYear W20601291862018 @default.
• W2060129186 countsByYear W20601291862019 @default.
• W2060129186 countsByYear W20601291862020 @default.
• W2060129186 countsByYear W20601291862021 @default.
• W2060129186 countsByYear W20601291862022 @default.
• W2060129186 countsByYear W20601291862023 @default.
• W2060129186 crossrefType "journal-article" @default.
• W2060129186 hasAuthorship W2060129186A5001808516 @default.
• W2060129186 hasAuthorship W2060129186A5024446602 @default.
• W2060129186 hasAuthorship W2060129186A5027097638 @default.
• W2060129186 hasAuthorship W2060129186A5048376181 @default.
• W2060129186 hasAuthorship W2060129186A5055873476 @default.
• W2060129186 hasAuthorship W2060129186A5055939605 @default.
• W2060129186 hasAuthorship W2060129186A5066296167 @default.
• W2060129186 hasAuthorship W2060129186A5086787191 @default.
• W2060129186 hasAuthorship W2060129186A5088659624 @default.
• W2060129186 hasAuthorship W2060129186A5091877145 @default.
• W2060129186 hasBestOaLocation W20601291861 @default.
• W2060129186 hasConcept C104317684 @default.
• W2060129186 hasConcept C11960822 @default.
• W2060129186 hasConcept C134018914 @default.
• W2060129186 hasConcept C168003608 @default.
• W2060129186 hasConcept C190283241 @default.
• W2060129186 hasConcept C203522944 @default.
• W2060129186 hasConcept C2777300911 @default.
• W2060129186 hasConcept C2777949483 @default.
• W2060129186 hasConcept C2779959927 @default.
• W2060129186 hasConcept C2780124434 @default.
• W2060129186 hasConcept C54355233 @default.
• W2060129186 hasConcept C62478195 @default.
• W2060129186 hasConcept C63645605 @default.
• W2060129186 hasConcept C6929976 @default.
• W2060129186 hasConcept C71680706 @default.
• W2060129186 hasConcept C75217442 @default.
• W2060129186 hasConcept C86554907 @default.
• W2060129186 hasConcept C86803240 @default.
• W2060129186 hasConcept C95444343 @default.

• next