FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061036786> ?p ?o ?g. }

• W2061036786 endingPage "463" @default.
• W2061036786 startingPage "452" @default.
• W2061036786 abstract "Dyskinesias represent a debilitating complication of levodopa therapy for Parkinson's disease (PD). While we recently demonstrated that levodopa-induced dyskinesia results from increased dopamine D(1) receptor-mediated transmission, we also questioned the possible role of subcellular localization of D(1) and D(2) receptors in mediating these effects as we previously showed that D(1) receptors undergo differential trafficking in striatal neurons of non-dyskinetic PD patients. Taking advantage of a monkey brain bank, we here report changes affecting the cellular and subcellular distribution of D(1) and D(2) dopamine receptors within the striatum of three experimental groups: normal, parkinsonian and dyskinetic L-dopa-treated parkinsonian animals. Our studies at both light and electron microscopy levels show a recruitment of D(1) receptor at the plasma membrane of striatal neurons in the parkinsonian animals and a strong increase of D(1) expression both at the membrane and in cytoplasm of dyskinetic animals, whereas D(2) receptor distribution is only modestly affected in all conditions. Our results rule out the hypothesis of a pathological overinternalization of dopamine receptors in levodopa-induced dyskinesia but raise the possibility for involvement of D(1) receptors in the priming phenomenon through massive and sudden internalization in response to the first ever administration of L-dopa and for an altered homologous desensitization mechanism in dyskinesia leading to an increased availability of D(1) receptors at membrane. Further experiments including parkinsonian monkeys chronically treated with L-dopa that show no dyskinesia and parkinsonian monkeys treated only once with L-dopa are now necessary to confirm our hypothesis." @default.
• W2061036786 created "2016-06-24" @default.
• W2061036786 creator A5004190849 @default.
• W2061036786 creator A5040707317 @default.
• W2061036786 creator A5059211262 @default.
• W2061036786 creator A5075080019 @default.
• W2061036786 creator A5077709259 @default.
• W2061036786 date "2007-05-01" @default.
• W2061036786 modified "2023-10-09" @default.
• W2061036786 title "Altered D1 dopamine receptor trafficking in parkinsonian and dyskinetic non-human primates" @default.
• W2061036786 cites W119628112 @default.
• W2061036786 cites W1557524937 @default.
• W2061036786 cites W1655808594 @default.
• W2061036786 cites W1966869556 @default.
• W2061036786 cites W1973101981 @default.
• W2061036786 cites W1979460462 @default.
• W2061036786 cites W1981609060 @default.
• W2061036786 cites W1984316985 @default.
• W2061036786 cites W1991603311 @default.
• W2061036786 cites W2010334584 @default.
• W2061036786 cites W2016133962 @default.
• W2061036786 cites W2017424741 @default.
• W2061036786 cites W2030222651 @default.
• W2061036786 cites W2035171463 @default.
• W2061036786 cites W2035286056 @default.
• W2061036786 cites W2046259479 @default.
• W2061036786 cites W2052427805 @default.
• W2061036786 cites W2056540920 @default.
• W2061036786 cites W2064134578 @default.
• W2061036786 cites W2071040174 @default.
• W2061036786 cites W2072970592 @default.
• W2061036786 cites W2086218381 @default.
• W2061036786 cites W2089704384 @default.
• W2061036786 cites W2093034788 @default.
• W2061036786 cites W2094182702 @default.
• W2061036786 cites W2095649828 @default.
• W2061036786 cites W2103744889 @default.
• W2061036786 cites W2104004822 @default.
• W2061036786 cites W2111885726 @default.
• W2061036786 cites W2119384581 @default.
• W2061036786 cites W2119588417 @default.
• W2061036786 cites W2130138967 @default.
• W2061036786 cites W2150949629 @default.
• W2061036786 cites W2166381457 @default.
• W2061036786 cites W2167264579 @default.
• W2061036786 doi "https://doi.org/10.1016/j.nbd.2007.02.001" @default.
• W2061036786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17350277" @default.
• W2061036786 hasPublicationYear "2007" @default.
• W2061036786 type Work @default.
• W2061036786 sameAs 2061036786 @default.
• W2061036786 citedByCount "129" @default.
• W2061036786 countsByYear W20610367862012 @default.
• W2061036786 countsByYear W20610367862013 @default.
• W2061036786 countsByYear W20610367862014 @default.
• W2061036786 countsByYear W20610367862015 @default.
• W2061036786 countsByYear W20610367862016 @default.
• W2061036786 countsByYear W20610367862017 @default.
• W2061036786 countsByYear W20610367862018 @default.
• W2061036786 countsByYear W20610367862019 @default.
• W2061036786 countsByYear W20610367862020 @default.
• W2061036786 countsByYear W20610367862021 @default.
• W2061036786 countsByYear W20610367862022 @default.
• W2061036786 crossrefType "journal-article" @default.
• W2061036786 hasAuthorship W2061036786A5004190849 @default.
• W2061036786 hasAuthorship W2061036786A5040707317 @default.
• W2061036786 hasAuthorship W2061036786A5059211262 @default.
• W2061036786 hasAuthorship W2061036786A5075080019 @default.
• W2061036786 hasAuthorship W2061036786A5077709259 @default.
• W2061036786 hasConcept C120069818 @default.
• W2061036786 hasConcept C126322002 @default.
• W2061036786 hasConcept C169760540 @default.
• W2061036786 hasConcept C170493617 @default.
• W2061036786 hasConcept C2779134260 @default.
• W2061036786 hasConcept C2779734285 @default.
• W2061036786 hasConcept C2780062018 @default.
• W2061036786 hasConcept C2780304432 @default.
• W2061036786 hasConcept C2780405171 @default.
• W2061036786 hasConcept C513476851 @default.
• W2061036786 hasConcept C71924100 @default.
• W2061036786 hasConcept C86803240 @default.
• W2061036786 hasConcept C98274493 @default.
• W2061036786 hasConceptScore W2061036786C120069818 @default.
• W2061036786 hasConceptScore W2061036786C126322002 @default.
• W2061036786 hasConceptScore W2061036786C169760540 @default.
• W2061036786 hasConceptScore W2061036786C170493617 @default.
• W2061036786 hasConceptScore W2061036786C2779134260 @default.
• W2061036786 hasConceptScore W2061036786C2779734285 @default.
• W2061036786 hasConceptScore W2061036786C2780062018 @default.
• W2061036786 hasConceptScore W2061036786C2780304432 @default.
• W2061036786 hasConceptScore W2061036786C2780405171 @default.
• W2061036786 hasConceptScore W2061036786C513476851 @default.
• W2061036786 hasConceptScore W2061036786C71924100 @default.
• W2061036786 hasConceptScore W2061036786C86803240 @default.
• W2061036786 hasConceptScore W2061036786C98274493 @default.
• W2061036786 hasIssue "2" @default.
• W2061036786 hasLocation W20610367861 @default.
• W2061036786 hasLocation W20610367862 @default.
• W2061036786 hasOpenAccess W2061036786 @default.

• next