FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2062401561> ?p ?o ?g. }

• W2062401561 endingPage "472" @default.
• W2062401561 startingPage "463" @default.
• W2062401561 abstract "Abstract A lethal human septic shock model, mouse generalized Shwartzman reaction (GSR), was elicited by two consecutive lippolysaccharide (LPS) injections (24 h apart) in which interferon-γ (IFN-γ) induced by interleukin (IL)-12 played a critical role in the priming phase, and tumor necrosis factor (TNF) was an important effector molecule in the second phase. We recently reported IL-12/LPS-induced mouse GSR age-dependently enhanced. We herein demonstrate that human peripheral blood mononuclear cells (PBMC) from healthy adults/elderly, cultured with IL-12 for 24 h and with LPS for an additional 24 h, produced a much larger amount of TNF (which increased age-dependently) than did PBMC without IL-12 priming. Whereas macrophages mainly produced TNF following LPS stimulation, macrophages and lymphocytes were necessary for a sufficient TNF production. IL-12-induced IFN-γ up-regulated Toll-like receptor 4 (TLR-4) on macrophages of adults. Although the PBMC from children produced a substantial amount of IFN-γ after IL-12 priming, the GSR response, with augmented TNF production and an up-regulated TLR-4 expression of macrophages, was not elicited by LPS stimulation. CD56+ natural killer cells, CD56+T cells, and CD57+T cells (NK-T cells), which age-dependently increased in PBMC, produced much larger amounts of IFN-γ after IL-12 priming than that of conventional CD56−CD57−T cells and also induced cocultured macrophages to produce TNF by subsequent LPS stimulation. The elder septic patients were consistently more susceptible to lethal shock with enhanced serum TNF levels than the adult patients. The NK cells, NK-T cells, and macrophages, which change proportionally or functionally with aging, might be involved in the enhanced GSR response/septic shock observed in elderly patients." @default.
• W2062401561 created "2016-06-24" @default.
• W2062401561 creator A5012426378 @default.
• W2062401561 creator A5030001987 @default.
• W2062401561 creator A5030805255 @default.
• W2062401561 creator A5032872485 @default.
• W2062401561 creator A5051249520 @default.
• W2062401561 creator A5052083749 @default.
• W2062401561 creator A5066970953 @default.
• W2062401561 creator A5076917742 @default.
• W2062401561 date "2005-12-30" @default.
• W2062401561 modified "2023-09-26" @default.
• W2062401561 title "An in vitro Shwartzman reaction-like response is augmented age-dependently in human peripheral blood mononuclear cells" @default.
• W2062401561 cites W1480644042 @default.
• W2062401561 cites W1483162601 @default.
• W2062401561 cites W1605072661 @default.
• W2062401561 cites W1615242172 @default.
• W2062401561 cites W1953464220 @default.
• W2062401561 cites W1964342706 @default.
• W2062401561 cites W1970185221 @default.
• W2062401561 cites W1974378526 @default.
• W2062401561 cites W1990972849 @default.
• W2062401561 cites W1993945633 @default.
• W2062401561 cites W2006098035 @default.
• W2062401561 cites W2022431667 @default.
• W2062401561 cites W2028872302 @default.
• W2062401561 cites W2029466803 @default.
• W2062401561 cites W2030778014 @default.
• W2062401561 cites W2036670221 @default.
• W2062401561 cites W2037771669 @default.
• W2062401561 cites W2040126676 @default.
• W2062401561 cites W2040689740 @default.
• W2062401561 cites W2051483818 @default.
• W2062401561 cites W2051790709 @default.
• W2062401561 cites W2055012394 @default.
• W2062401561 cites W2060222319 @default.
• W2062401561 cites W2062922499 @default.
• W2062401561 cites W2067167556 @default.
• W2062401561 cites W2070067903 @default.
• W2062401561 cites W2072344266 @default.
• W2062401561 cites W2072502005 @default.
• W2062401561 cites W2082903265 @default.
• W2062401561 cites W2086786702 @default.
• W2062401561 cites W2087492521 @default.
• W2062401561 cites W2093413494 @default.
• W2062401561 cites W2098613657 @default.
• W2062401561 cites W2102872496 @default.
• W2062401561 cites W2103289907 @default.
• W2062401561 cites W2122247332 @default.
• W2062401561 cites W2127103640 @default.
• W2062401561 cites W2128759062 @default.
• W2062401561 cites W2129319296 @default.
• W2062401561 cites W2129842669 @default.
• W2062401561 cites W2133101303 @default.
• W2062401561 cites W2139226057 @default.
• W2062401561 cites W2145619203 @default.
• W2062401561 cites W2160050673 @default.
• W2062401561 cites W2160704701 @default.
• W2062401561 cites W2328441254 @default.
• W2062401561 cites W2469889825 @default.
• W2062401561 cites W2768146862 @default.
• W2062401561 cites W4313333873 @default.
• W2062401561 doi "https://doi.org/10.1189/jlb.0705396" @default.
• W2062401561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16387840" @default.
• W2062401561 hasPublicationYear "2005" @default.
• W2062401561 type Work @default.
• W2062401561 sameAs 2062401561 @default.
• W2062401561 citedByCount "22" @default.
• W2062401561 countsByYear W20624015612013 @default.
• W2062401561 countsByYear W20624015612014 @default.
• W2062401561 countsByYear W20624015612016 @default.
• W2062401561 countsByYear W20624015612018 @default.
• W2062401561 countsByYear W20624015612019 @default.
• W2062401561 countsByYear W20624015612020 @default.
• W2062401561 countsByYear W20624015612021 @default.
• W2062401561 countsByYear W20624015612023 @default.
• W2062401561 crossrefType "journal-article" @default.
• W2062401561 hasAuthorship W2062401561A5012426378 @default.
• W2062401561 hasAuthorship W2062401561A5030001987 @default.
• W2062401561 hasAuthorship W2062401561A5030805255 @default.
• W2062401561 hasAuthorship W2062401561A5032872485 @default.
• W2062401561 hasAuthorship W2062401561A5051249520 @default.
• W2062401561 hasAuthorship W2062401561A5052083749 @default.
• W2062401561 hasAuthorship W2062401561A5066970953 @default.
• W2062401561 hasAuthorship W2062401561A5076917742 @default.
• W2062401561 hasConcept C100701293 @default.
• W2062401561 hasConcept C134018914 @default.
• W2062401561 hasConcept C137061746 @default.
• W2062401561 hasConcept C149532602 @default.
• W2062401561 hasConcept C154317977 @default.
• W2062401561 hasConcept C17991360 @default.
• W2062401561 hasConcept C202751555 @default.
• W2062401561 hasConcept C203014093 @default.
• W2062401561 hasConcept C24998067 @default.
• W2062401561 hasConcept C2776178377 @default.
• W2062401561 hasConcept C2777628635 @default.
• W2062401561 hasConcept C2778384902 @default.
• W2062401561 hasConcept C2778690821 @default.

• next