FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063336343> ?p ?o ?g. }

• W2063336343 endingPage "173" @default.
• W2063336343 startingPage "167" @default.
• W2063336343 abstract "We studied a signaling pathway for the activation of the superoxide (O2-)-generating NADPH oxidase and effects of cAMP on the pathway using electropermeabilized human neutrophils. The permeabilized cells produced O2- by the addition of protein kinase C (PKC) activator, phorbol myristate acetate (PMA), and a non-hydrolyzable GTP analogue, GTP gamma S in the presence of ATP and Mg2+. The O2- production by PMA not by GTP gamma S was inhibited by inhibitors of PKC. The production by PMA and GTP gamma S was inhibited by a GDP analogue, GDP beta S, in the same dose-dependent manner and the production by PMA was not enhanced by the addition of GTP gamma S and vice versa. These findings suggest the presence of a GTP-binding protein which follows PKC in the activation pathway. The O2- production by PMA and GTP gamma S was dose-dependently inhibited by cAMP and the inhibition was completely restored by an inhibitor of cAMP-dependent protein kinase, H-89, indicating that cAMP blocks the activating pathway at the site between the GTP-binding protein located downstream of PKC and the NADPH oxidase by activating cAMP-dependent protein kinase. The activation of the oxidase by sodium dodecyl sulfate (SDS) seemed to be different from the above pathway. It needed higher concentrations of GDP beta S for inhibition, did not absolutely need ATP and was inhibited by neither cAMP nor protein kinase C inhibitors. Moreover, the O2- production by the combination of GTP gamma S and SDS or of PMA and SDS was essentially the same as the sum of the production by each stimulant alone. We may conclude from the observations that the signaling pathway involving PKC for the activation of the oxidase is distinct from the pathway induced by SDS: the former is blocked by cAMP at the site between the GTP-binding protein located downstream of PKC and the oxidase and the latter is cAMP-insensitive." @default.
• W2063336343 created "2016-06-24" @default.
• W2063336343 creator A5002479841 @default.
• W2063336343 creator A5052131630 @default.
• W2063336343 creator A5088479379 @default.
• W2063336343 date "1993-06-01" @default.
• W2063336343 modified "2023-09-24" @default.
• W2063336343 title "Cyclic AMP inhibits the respiratory burst of electropermeabilized human neutrophils at a downstream site of protein kinase C" @default.
• W2063336343 cites W126889650 @default.
• W2063336343 cites W1481438484 @default.
• W2063336343 cites W1485049172 @default.
• W2063336343 cites W1499930709 @default.
• W2063336343 cites W1505499143 @default.
• W2063336343 cites W1526061497 @default.
• W2063336343 cites W1534174729 @default.
• W2063336343 cites W1546164822 @default.
• W2063336343 cites W1558257735 @default.
• W2063336343 cites W1581237266 @default.
• W2063336343 cites W1592428766 @default.
• W2063336343 cites W1974692235 @default.
• W2063336343 cites W1975275482 @default.
• W2063336343 cites W1984200009 @default.
• W2063336343 cites W1991507982 @default.
• W2063336343 cites W1993574643 @default.
• W2063336343 cites W1997945127 @default.
• W2063336343 cites W1998611816 @default.
• W2063336343 cites W2001402011 @default.
• W2063336343 cites W2002979924 @default.
• W2063336343 cites W2012705275 @default.
• W2063336343 cites W201443300 @default.
• W2063336343 cites W2022185868 @default.
• W2063336343 cites W2028472874 @default.
• W2063336343 cites W2035183484 @default.
• W2063336343 cites W2037128614 @default.
• W2063336343 cites W2041237554 @default.
• W2063336343 cites W2049267505 @default.
• W2063336343 cites W2049856962 @default.
• W2063336343 cites W2050719029 @default.
• W2063336343 cites W2065432636 @default.
• W2063336343 cites W2072178579 @default.
• W2063336343 cites W2075473225 @default.
• W2063336343 cites W2081929795 @default.
• W2063336343 cites W2084699108 @default.
• W2063336343 cites W2089887078 @default.
• W2063336343 cites W2092933435 @default.
• W2063336343 cites W2093547993 @default.
• W2063336343 cites W2174934515 @default.
• W2063336343 cites W2238810682 @default.
• W2063336343 cites W2472449491 @default.
• W2063336343 cites W3023000517 @default.
• W2063336343 cites W4234044995 @default.
• W2063336343 doi "https://doi.org/10.1016/0167-4889(93)90036-o" @default.
• W2063336343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8388737" @default.
• W2063336343 hasPublicationYear "1993" @default.
• W2063336343 type Work @default.
• W2063336343 sameAs 2063336343 @default.
• W2063336343 citedByCount "28" @default.
• W2063336343 countsByYear W20633363432012 @default.
• W2063336343 countsByYear W20633363432017 @default.
• W2063336343 countsByYear W20633363432021 @default.
• W2063336343 crossrefType "journal-article" @default.
• W2063336343 hasAuthorship W2063336343A5002479841 @default.
• W2063336343 hasAuthorship W2063336343A5052131630 @default.
• W2063336343 hasAuthorship W2063336343A5088479379 @default.
• W2063336343 hasConcept C118716 @default.
• W2063336343 hasConcept C153911025 @default.
• W2063336343 hasConcept C170493617 @default.
• W2063336343 hasConcept C181199279 @default.
• W2063336343 hasConcept C184235292 @default.
• W2063336343 hasConcept C185592680 @default.
• W2063336343 hasConcept C195794163 @default.
• W2063336343 hasConcept C2779719074 @default.
• W2063336343 hasConcept C2780043322 @default.
• W2063336343 hasConcept C55493867 @default.
• W2063336343 hasConcept C62478195 @default.
• W2063336343 hasConcept C80631254 @default.
• W2063336343 hasConcept C86803240 @default.
• W2063336343 hasConcept C88045685 @default.
• W2063336343 hasConcept C95444343 @default.
• W2063336343 hasConcept C97029542 @default.
• W2063336343 hasConceptScore W2063336343C118716 @default.
• W2063336343 hasConceptScore W2063336343C153911025 @default.
• W2063336343 hasConceptScore W2063336343C170493617 @default.
• W2063336343 hasConceptScore W2063336343C181199279 @default.
• W2063336343 hasConceptScore W2063336343C184235292 @default.
• W2063336343 hasConceptScore W2063336343C185592680 @default.
• W2063336343 hasConceptScore W2063336343C195794163 @default.
• W2063336343 hasConceptScore W2063336343C2779719074 @default.
• W2063336343 hasConceptScore W2063336343C2780043322 @default.
• W2063336343 hasConceptScore W2063336343C55493867 @default.
• W2063336343 hasConceptScore W2063336343C62478195 @default.
• W2063336343 hasConceptScore W2063336343C80631254 @default.
• W2063336343 hasConceptScore W2063336343C86803240 @default.
• W2063336343 hasConceptScore W2063336343C88045685 @default.
• W2063336343 hasConceptScore W2063336343C95444343 @default.
• W2063336343 hasConceptScore W2063336343C97029542 @default.
• W2063336343 hasFunder F4320320912 @default.
• W2063336343 hasIssue "2" @default.

• next