FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2063733533> ?p ?o ?g. }

• W2063733533 endingPage "424" @default.
• W2063733533 startingPage "415" @default.
• W2063733533 abstract "The present study investigates whether immunostimulated glial expression of inducible nitric oxide synthase influences the glucose deprivation–induced death of rat cerebellar granule cells (CGC). CGC/glia cocultures were immunostimulated by interferon-γ (200 U/ml) and lipopolysaccharides (1 μg/ml) and 2 days later were challenged by glucose deprivation. Neurotoxicity was assessed by measuring the release of lactate dehydrogenase. Neither a 2-h glucose deprivation nor a 2-day immunostimulation altered the viability of CGC. A 2-day immunostimulation, however, markedly potentiated the glucose deprivation–induced death of CGC. The increased death of glucose-deprived CGC after immunostimulation was mimicked by the nitric oxide (NO) releasing reagent 3-morpholinosydnonimine (SIN-1) and was partially prevented by the NO synthase (NOS) inhibitor NG-nitroarginine. The increased death of glucose-deprived CGC either after immunostimulation or by SIN-1 was not altered by various N-methyl-d-aspartate (NMDA) and non-NMDA receptor antagonists. Because Superoxide dismutase and catalase, which remove Superoxide anion, decreased the augmented death of glucose-deprived immunostimulated CGC, the reaction of NO with Superoxide to form peroxynitrite appears to be implicated in the potentiated neurotoxicity. Our data indicate that immunostimulated glial cells potentiate the death of glucose-deprived neurons in part through the expression of inducible NOS but not through NMDA receptor activation. Potentiation of glucose-deprived CGC death by immunostimulated glial cells may be clinically implicated in the tendency of recurrent ischemic insults to be more severe and fatal than an initial ischemic insult." @default.
• W2063733533 created "2016-06-24" @default.
• W2063733533 creator A5021563502 @default.
• W2063733533 creator A5041418845 @default.
• W2063733533 creator A5066461573 @default.
• W2063733533 creator A5086207446 @default.
• W2063733533 date "1999-05-01" @default.
• W2063733533 modified "2023-09-30" @default.
• W2063733533 title "Immunostimulated Glial Cells Potentiate Glucose Deprivation-Induced Death of Cultured Rat Cerebellar Granule Cells" @default.
• W2063733533 cites W1500094754 @default.
• W2063733533 cites W157207490 @default.
• W2063733533 cites W1606988289 @default.
• W2063733533 cites W1912243307 @default.
• W2063733533 cites W1957958801 @default.
• W2063733533 cites W1966355939 @default.
• W2063733533 cites W1969373337 @default.
• W2063733533 cites W1969530182 @default.
• W2063733533 cites W1978348298 @default.
• W2063733533 cites W1979230311 @default.
• W2063733533 cites W1982541458 @default.
• W2063733533 cites W1988726352 @default.
• W2063733533 cites W1997611160 @default.
• W2063733533 cites W1998775044 @default.
• W2063733533 cites W1999087101 @default.
• W2063733533 cites W2002285876 @default.
• W2063733533 cites W2013065340 @default.
• W2063733533 cites W2025629499 @default.
• W2063733533 cites W2034407799 @default.
• W2063733533 cites W2037495529 @default.
• W2063733533 cites W2047053137 @default.
• W2063733533 cites W2054130988 @default.
• W2063733533 cites W2059192931 @default.
• W2063733533 cites W2062384458 @default.
• W2063733533 cites W2069349973 @default.
• W2063733533 cites W2070558689 @default.
• W2063733533 cites W2071394393 @default.
• W2063733533 cites W2074022605 @default.
• W2063733533 cites W2074187719 @default.
• W2063733533 cites W2082011784 @default.
• W2063733533 cites W2086168158 @default.
• W2063733533 cites W2092145002 @default.
• W2063733533 cites W2144530503 @default.
• W2063733533 doi "https://doi.org/10.1089/neu.1999.16.415" @default.
• W2063733533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10369561" @default.
• W2063733533 hasPublicationYear "1999" @default.
• W2063733533 type Work @default.
• W2063733533 sameAs 2063733533 @default.
• W2063733533 citedByCount "18" @default.
• W2063733533 countsByYear W20637335332012 @default.
• W2063733533 countsByYear W20637335332013 @default.
• W2063733533 countsByYear W20637335332016 @default.
• W2063733533 crossrefType "journal-article" @default.
• W2063733533 hasAuthorship W2063733533A5021563502 @default.
• W2063733533 hasAuthorship W2063733533A5041418845 @default.
• W2063733533 hasAuthorship W2063733533A5066461573 @default.
• W2063733533 hasAuthorship W2063733533A5086207446 @default.
• W2063733533 hasConcept C126322002 @default.
• W2063733533 hasConcept C134018914 @default.
• W2063733533 hasConcept C170493617 @default.
• W2063733533 hasConcept C181199279 @default.
• W2063733533 hasConcept C185592680 @default.
• W2063733533 hasConcept C190283241 @default.
• W2063733533 hasConcept C2775838275 @default.
• W2063733533 hasConcept C2776151105 @default.
• W2063733533 hasConcept C2777318727 @default.
• W2063733533 hasConcept C2777622882 @default.
• W2063733533 hasConcept C2778784160 @default.
• W2063733533 hasConcept C2779491297 @default.
• W2063733533 hasConcept C2780795997 @default.
• W2063733533 hasConcept C29730261 @default.
• W2063733533 hasConcept C31573885 @default.
• W2063733533 hasConcept C519581460 @default.
• W2063733533 hasConcept C55493867 @default.
• W2063733533 hasConcept C61174792 @default.
• W2063733533 hasConcept C67018056 @default.
• W2063733533 hasConcept C71924100 @default.
• W2063733533 hasConcept C86803240 @default.
• W2063733533 hasConceptScore W2063733533C126322002 @default.
• W2063733533 hasConceptScore W2063733533C134018914 @default.
• W2063733533 hasConceptScore W2063733533C170493617 @default.
• W2063733533 hasConceptScore W2063733533C181199279 @default.
• W2063733533 hasConceptScore W2063733533C185592680 @default.
• W2063733533 hasConceptScore W2063733533C190283241 @default.
• W2063733533 hasConceptScore W2063733533C2775838275 @default.
• W2063733533 hasConceptScore W2063733533C2776151105 @default.
• W2063733533 hasConceptScore W2063733533C2777318727 @default.
• W2063733533 hasConceptScore W2063733533C2777622882 @default.
• W2063733533 hasConceptScore W2063733533C2778784160 @default.
• W2063733533 hasConceptScore W2063733533C2779491297 @default.
• W2063733533 hasConceptScore W2063733533C2780795997 @default.
• W2063733533 hasConceptScore W2063733533C29730261 @default.
• W2063733533 hasConceptScore W2063733533C31573885 @default.
• W2063733533 hasConceptScore W2063733533C519581460 @default.
• W2063733533 hasConceptScore W2063733533C55493867 @default.
• W2063733533 hasConceptScore W2063733533C61174792 @default.
• W2063733533 hasConceptScore W2063733533C67018056 @default.
• W2063733533 hasConceptScore W2063733533C71924100 @default.
• W2063733533 hasConceptScore W2063733533C86803240 @default.

• next