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- W2066465950 abstract "Abstract Background The increasing incidence of hepatocellular carcinoma in Western countries has led to an expanding interest of scientific research in this field. Therefore, a vast need of experimental models that mimic the natural pathogenesis of hepatocellular carcinoma (HCC) in a short time period is present. The goal of our study was (1) to develop an efficient mouse model for HCC research, in which tumours develop in a natural background of fibrosis and (2) to assess the time-dependent angiogenic changes in the pathogenesis of HCC. Methods Weekly intraperitoneal injections with the hepatocarcinogenic compound N-nitrosodiethylamine was applied as induction method and samples were taken at several time points to assess the angiogenic changes during the progression of HCC. Results The N-nitrosodiethylamine-induced mouse model provides well vascularised orthotopic tumours after 25 weeks. It is a representative model for human HCC and can serve as an excellent platform for the development of new therapeutic targets." @default.
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- W2066465950 date "2010-08-20" @default.
- W2066465950 modified "2023-10-15" @default.
- W2066465950 title "Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma" @default.
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- W2066465950 doi "https://doi.org/10.1186/1476-4598-9-219" @default.
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