FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2066702909> ?p ?o ?g. }

• W2066702909 endingPage "25" @default.
• W2066702909 startingPage "15" @default.
• W2066702909 abstract "We investigated the effects of hypergravity on DNA synthesis and alkaline phosphatase (ALP) activity in cloned osteoblast-like cells. MC3T3-E1. Hypergravity (5 × g) stimulated DNA synthesis in these cells in a time-dependent manner and increased it approximately up to 150% of that of the control (1 × g). 12-O-Tetra-decanoylphorbol-13-acetate (TPA), a protein kinase C activator, and insulin-like growth factor I (IGF-I) enhanced DNA synthesis additively with hypergravity (5 × g). An increase in ALP activity induced by 10% fetal calf serum (FCS) was suppressed by hypergravity (2 × g, 5 × g). Five × g completely suppressed the increase in ALP activity. TPA and hypergravity (2 × g) suppressed the increase in ALP activity induced by FCS additively. Hypergravity (5 × g) showed no significant effect on cAMP nor cGMP production in these cells, but increased prostaglandin E2 (PGE2) production. Exogenous PGE2 stimulated DNA synthesis in these cells but had little effect on 10% FCS-induced ALP activity. These results suggest that hypergravity stimulates proliferation but suppresses differentiation of osteoblast-like cells through a pathway independent of the activation of protein kinase C and the production of cyclic nucleotides, and that hypergravity and IGF-I stimulate proliferation of these cells through an independent signal transduction pathway. Moreover, our data strongly suggest that PGE2 mediates the signalling of hypergravity on the proliferation of osteoblast-like cells." @default.
• W2066702909 created "2016-06-24" @default.
• W2066702909 creator A5019070623 @default.
• W2066702909 creator A5025863828 @default.
• W2066702909 creator A5027941670 @default.
• W2066702909 creator A5044068821 @default.
• W2066702909 creator A5055018173 @default.
• W2066702909 creator A5056821899 @default.
• W2066702909 creator A5083502334 @default.
• W2066702909 date "1991-07-01" @default.
• W2066702909 modified "2023-09-26" @default.
• W2066702909 title "Effects of hypergravity on proliferation and differentiation of osteoblast-like cells" @default.
• W2066702909 cites W1584737584 @default.
• W2066702909 cites W1597529692 @default.
• W2066702909 cites W1919121454 @default.
• W2066702909 cites W1964839077 @default.
• W2066702909 cites W1968738869 @default.
• W2066702909 cites W1973723885 @default.
• W2066702909 cites W1988410396 @default.
• W2066702909 cites W1991027949 @default.
• W2066702909 cites W2006880764 @default.
• W2066702909 cites W2013497004 @default.
• W2066702909 cites W2027126905 @default.
• W2066702909 cites W2040982919 @default.
• W2066702909 cites W2047453707 @default.
• W2066702909 cites W2058438078 @default.
• W2066702909 cites W2058707027 @default.
• W2066702909 cites W2061037159 @default.
• W2066702909 cites W2064025989 @default.
• W2066702909 cites W2067986741 @default.
• W2066702909 cites W2080170045 @default.
• W2066702909 cites W2084152511 @default.
• W2066702909 cites W2104161119 @default.
• W2066702909 cites W2145349151 @default.
• W2066702909 cites W2159459710 @default.
• W2066702909 cites W4248270 @default.
• W2066702909 doi "https://doi.org/10.1016/0169-6009(91)90099-l" @default.
• W2066702909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1651138" @default.
• W2066702909 hasPublicationYear "1991" @default.
• W2066702909 type Work @default.
• W2066702909 sameAs 2066702909 @default.
• W2066702909 citedByCount "38" @default.
• W2066702909 countsByYear W20667029092013 @default.
• W2066702909 countsByYear W20667029092015 @default.
• W2066702909 countsByYear W20667029092016 @default.
• W2066702909 countsByYear W20667029092018 @default.
• W2066702909 countsByYear W20667029092019 @default.
• W2066702909 countsByYear W20667029092022 @default.
• W2066702909 countsByYear W20667029092023 @default.
• W2066702909 crossrefType "journal-article" @default.
• W2066702909 hasAuthorship W2066702909A5019070623 @default.
• W2066702909 hasAuthorship W2066702909A5025863828 @default.
• W2066702909 hasAuthorship W2066702909A5027941670 @default.
• W2066702909 hasAuthorship W2066702909A5044068821 @default.
• W2066702909 hasAuthorship W2066702909A5055018173 @default.
• W2066702909 hasAuthorship W2066702909A5056821899 @default.
• W2066702909 hasAuthorship W2066702909A5083502334 @default.
• W2066702909 hasConcept C104317684 @default.
• W2066702909 hasConcept C126322002 @default.
• W2066702909 hasConcept C128709446 @default.
• W2066702909 hasConcept C134018914 @default.
• W2066702909 hasConcept C148738053 @default.
• W2066702909 hasConcept C160160445 @default.
• W2066702909 hasConcept C170493617 @default.
• W2066702909 hasConcept C181199279 @default.
• W2066702909 hasConcept C185592680 @default.
• W2066702909 hasConcept C202751555 @default.
• W2066702909 hasConcept C2778260815 @default.
• W2066702909 hasConcept C552990157 @default.
• W2066702909 hasConcept C55493867 @default.
• W2066702909 hasConcept C62478195 @default.
• W2066702909 hasConcept C64241487 @default.
• W2066702909 hasConcept C71924100 @default.
• W2066702909 hasConcept C86803240 @default.
• W2066702909 hasConcept C88045685 @default.
• W2066702909 hasConcept C95444343 @default.
• W2066702909 hasConceptScore W2066702909C104317684 @default.
• W2066702909 hasConceptScore W2066702909C126322002 @default.
• W2066702909 hasConceptScore W2066702909C128709446 @default.
• W2066702909 hasConceptScore W2066702909C134018914 @default.
• W2066702909 hasConceptScore W2066702909C148738053 @default.
• W2066702909 hasConceptScore W2066702909C160160445 @default.
• W2066702909 hasConceptScore W2066702909C170493617 @default.
• W2066702909 hasConceptScore W2066702909C181199279 @default.
• W2066702909 hasConceptScore W2066702909C185592680 @default.
• W2066702909 hasConceptScore W2066702909C202751555 @default.
• W2066702909 hasConceptScore W2066702909C2778260815 @default.
• W2066702909 hasConceptScore W2066702909C552990157 @default.
• W2066702909 hasConceptScore W2066702909C55493867 @default.
• W2066702909 hasConceptScore W2066702909C62478195 @default.
• W2066702909 hasConceptScore W2066702909C64241487 @default.
• W2066702909 hasConceptScore W2066702909C71924100 @default.
• W2066702909 hasConceptScore W2066702909C86803240 @default.
• W2066702909 hasConceptScore W2066702909C88045685 @default.
• W2066702909 hasConceptScore W2066702909C95444343 @default.
• W2066702909 hasIssue "1" @default.
• W2066702909 hasLocation W20667029091 @default.
• W2066702909 hasLocation W20667029092 @default.

• next