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- W2067804511 endingPage "1579" @default.
- W2067804511 startingPage "1575" @default.
- W2067804511 abstract "Components of a signaling pathway that couples the ciliary neurotrophic factor (CNTF) receptor to induction of transcription were identified. CNTF stimulated the tyrosine phosphorylation of p91, a protein implicated in interferon signaling pathways, and of two proteins that are distinct but related to p91. Tyrosine-phosphorylated p91 translocated to the nucleus, where p91 and p91-related proteins bound to a DNA sequence found in promoters of genes responsive to CNTF. This DNA sequence, when inserted upstream of a reporter gene, conferred a transcriptional response to CNTF. A pathway that transduces interferon signals may therefore have a more general function in the propagation of responses to certain neurotrophic factors." @default.
- W2067804511 created "2016-06-24" @default.
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- W2067804511 date "1993-12-03" @default.
- W2067804511 modified "2023-09-27" @default.
- W2067804511 title "Characterization of a Pathway for Ciliary Neurotrophic Factor Signaling to the Nucleus" @default.
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- W2067804511 doi "https://doi.org/10.1126/science.7504325" @default.
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