Matches in SemOpenAlex for { <https://semopenalex.org/work/W2068007102> ?p ?o ?g. }
- W2068007102 endingPage "399" @default.
- W2068007102 startingPage "395" @default.
- W2068007102 abstract "Abstract To evaluate the distribution of usage and to quantify the transcription levels of the immunoglobulin lambda variable ( IGLV ) genes in patients with systemic lupus erythematosus (SLE) and normal individuals (NIs), cDNA samples from peripheral blood lymphocytes were prepared and probed with IGLV‐specific oligonucleotides. Because recombinations involving V‐lambda pseudogenes are nonproductive, we analysed the IGLV productive repertoire, as cDNAs were copied from IGLV mRNA producing B lymphocytes. Increased expression of the IGLV8a gene in SLE led us to analyse the transcription levels of all IGLV genes. We developed an expression profiling approach to scan the entire V‐lambda locus on chromosome 22q11.2. The transcription profiling showed that usually the V‐lambda genes located near the Jλ–Cλ cluster were preferentially expressed in both groups, i.e. patients and NIs, with the expression levels of SLE patients being significantly higher. However, genes displaying peaks of expression independent of Jλ–Cλ cluster proximity were observed along the IGLV locus. Our data permit us to conclude that there are differences in V‐lambda gene expression between SLE patients and NIs, and a preferential usage of genes located near the Jλ–Cλ cluster. The data also demonstrate the occurrence of Vλ–Jλ–Cλ‐productive recombinations independent of gene localization along the locus." @default.
- W2068007102 created "2016-06-24" @default.
- W2068007102 creator A5002854120 @default.
- W2068007102 creator A5003876335 @default.
- W2068007102 creator A5028687670 @default.
- W2068007102 creator A5087068579 @default.
- W2068007102 date "2004-03-26" @default.
- W2068007102 modified "2023-10-10" @default.
- W2068007102 title "Immunoglobulin V-Lambda Transcription Profiling of Systemic Lupus Erythematosus Patients Reveals Biased Usage of Genes Located Near the Jlambda-Clambda Segments" @default.
- W2068007102 cites W1520370731 @default.
- W2068007102 cites W1535006969 @default.
- W2068007102 cites W1552738427 @default.
- W2068007102 cites W1930908207 @default.
- W2068007102 cites W1966510737 @default.
- W2068007102 cites W1992985748 @default.
- W2068007102 cites W1998434376 @default.
- W2068007102 cites W2010664601 @default.
- W2068007102 cites W2012953012 @default.
- W2068007102 cites W2063199750 @default.
- W2068007102 cites W2066141360 @default.
- W2068007102 cites W2068380103 @default.
- W2068007102 cites W2069183168 @default.
- W2068007102 cites W2070814047 @default.
- W2068007102 cites W2090841599 @default.
- W2068007102 cites W2102566053 @default.
- W2068007102 cites W2105029898 @default.
- W2068007102 cites W2135500109 @default.
- W2068007102 cites W2142958651 @default.
- W2068007102 cites W2146203649 @default.
- W2068007102 cites W2150144834 @default.
- W2068007102 cites W4313341505 @default.
- W2068007102 cites W4313347827 @default.
- W2068007102 doi "https://doi.org/10.1111/j.0300-9475.2004.01407.x" @default.
- W2068007102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15049783" @default.
- W2068007102 hasPublicationYear "2004" @default.
- W2068007102 type Work @default.
- W2068007102 sameAs 2068007102 @default.
- W2068007102 citedByCount "3" @default.
- W2068007102 countsByYear W20680071022021 @default.
- W2068007102 crossrefType "journal-article" @default.
- W2068007102 hasAuthorship W2068007102A5002854120 @default.
- W2068007102 hasAuthorship W2068007102A5003876335 @default.
- W2068007102 hasAuthorship W2068007102A5028687670 @default.
- W2068007102 hasAuthorship W2068007102A5087068579 @default.
- W2068007102 hasBestOaLocation W20680071021 @default.
- W2068007102 hasConcept C104317684 @default.
- W2068007102 hasConcept C120665830 @default.
- W2068007102 hasConcept C121332964 @default.
- W2068007102 hasConcept C138885662 @default.
- W2068007102 hasConcept C141231307 @default.
- W2068007102 hasConcept C150194340 @default.
- W2068007102 hasConcept C153911025 @default.
- W2068007102 hasConcept C159654299 @default.
- W2068007102 hasConcept C179926584 @default.
- W2068007102 hasConcept C18431079 @default.
- W2068007102 hasConcept C187882448 @default.
- W2068007102 hasConcept C2778113609 @default.
- W2068007102 hasConcept C34957205 @default.
- W2068007102 hasConcept C41895202 @default.
- W2068007102 hasConcept C54355233 @default.
- W2068007102 hasConcept C84597430 @default.
- W2068007102 hasConcept C86803240 @default.
- W2068007102 hasConceptScore W2068007102C104317684 @default.
- W2068007102 hasConceptScore W2068007102C120665830 @default.
- W2068007102 hasConceptScore W2068007102C121332964 @default.
- W2068007102 hasConceptScore W2068007102C138885662 @default.
- W2068007102 hasConceptScore W2068007102C141231307 @default.
- W2068007102 hasConceptScore W2068007102C150194340 @default.
- W2068007102 hasConceptScore W2068007102C153911025 @default.
- W2068007102 hasConceptScore W2068007102C159654299 @default.
- W2068007102 hasConceptScore W2068007102C179926584 @default.
- W2068007102 hasConceptScore W2068007102C18431079 @default.
- W2068007102 hasConceptScore W2068007102C187882448 @default.
- W2068007102 hasConceptScore W2068007102C2778113609 @default.
- W2068007102 hasConceptScore W2068007102C34957205 @default.
- W2068007102 hasConceptScore W2068007102C41895202 @default.
- W2068007102 hasConceptScore W2068007102C54355233 @default.
- W2068007102 hasConceptScore W2068007102C84597430 @default.
- W2068007102 hasConceptScore W2068007102C86803240 @default.
- W2068007102 hasIssue "4" @default.
- W2068007102 hasLocation W20680071021 @default.
- W2068007102 hasLocation W20680071022 @default.
- W2068007102 hasOpenAccess W2068007102 @default.
- W2068007102 hasPrimaryLocation W20680071021 @default.
- W2068007102 hasRelatedWork W1491700128 @default.
- W2068007102 hasRelatedWork W1977805690 @default.
- W2068007102 hasRelatedWork W2003343781 @default.
- W2068007102 hasRelatedWork W2059178206 @default.
- W2068007102 hasRelatedWork W2118397457 @default.
- W2068007102 hasRelatedWork W2144270675 @default.
- W2068007102 hasRelatedWork W2367624822 @default.
- W2068007102 hasRelatedWork W2769050893 @default.
- W2068007102 hasRelatedWork W2808331510 @default.
- W2068007102 hasRelatedWork W4239511280 @default.
- W2068007102 hasVolume "59" @default.
- W2068007102 isParatext "false" @default.
- W2068007102 isRetracted "false" @default.
- W2068007102 magId "2068007102" @default.