FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2069103615> ?p ?o ?g. }

• W2069103615 endingPage "1719" @default.
• W2069103615 startingPage "1710" @default.
• W2069103615 abstract "A functioning vascular supply is essential for solid tumor growth and metastases, which means that blood vessels are an ideal target for antitumor drug discovery. Targeting tumor vasculature involves two main approaches, anti-angiogenesis and vascular disruption. The anti-angiogenic and vascular disrupting activities of deoxypodophyllotoxin (DPT), a natural microtubule destabilizer, were examined with several in vitro, ex vivo and/or in vivo models. First, we demonstrated that DPT significantly inhibits the proliferation, migration and tube formation of endothelial cells and inhibits angiogenesis in rat aortic ring and chick chorioallantoic membrane assays. In further studies, DPT induced cytoskeleton reorganization in endothelial cells, which likely contributed to the anti-angiogenic effect at non-cytotoxic concentrations. DPT treatment at higher concentrations for longer time induced the cell cycle arrest, which may contributes to its anti-proliferation effect and anti-angiogenic activity. And DPT dramatically inducted the expression of cyclin B1 and p21 (WAF1/CIP1). Meanwhile, DPT disrupted capillary-like networks in vitro and newly formed vessels from rat aortic rings. Endothelial cell contraction associated with an increase in F-actin via the Rho/Rho kinase pathway likely contributed to the vascular disrupting activity. Taken together, our results provided the initial evidence that DPT exerts potent anti-angiogenic and vascular disrupting effects. This study also provides important insight into the mechanism of action of promising new anticancer drugs with both anti-angiogenic and vascular disrupting activities." @default.
• W2069103615 created "2016-06-24" @default.
• W2069103615 creator A5002705826 @default.
• W2069103615 creator A5002744113 @default.
• W2069103615 creator A5003128598 @default.
• W2069103615 creator A5031734558 @default.
• W2069103615 creator A5046605612 @default.
• W2069103615 creator A5058165407 @default.
• W2069103615 creator A5064466975 @default.
• W2069103615 creator A5076176069 @default.
• W2069103615 creator A5076251001 @default.
• W2069103615 creator A5077650477 @default.
• W2069103615 creator A5090494061 @default.
• W2069103615 date "2013-08-01" @default.
• W2069103615 modified "2023-10-05" @default.
• W2069103615 title "Deoxypodophyllotoxin exerts both anti-angiogenic and vascular disrupting effects" @default.
• W2069103615 cites W1551389275 @default.
• W2069103615 cites W1573363574 @default.
• W2069103615 cites W1985348675 @default.
• W2069103615 cites W1988202409 @default.
• W2069103615 cites W1991123816 @default.
• W2069103615 cites W1995168398 @default.
• W2069103615 cites W2007687296 @default.
• W2069103615 cites W2014642781 @default.
• W2069103615 cites W2029852728 @default.
• W2069103615 cites W2030756834 @default.
• W2069103615 cites W2035210263 @default.
• W2069103615 cites W2054979979 @default.
• W2069103615 cites W2055040869 @default.
• W2069103615 cites W2057640807 @default.
• W2069103615 cites W2061698887 @default.
• W2069103615 cites W2062183635 @default.
• W2069103615 cites W2064721285 @default.
• W2069103615 cites W2065256743 @default.
• W2069103615 cites W2079448479 @default.
• W2069103615 cites W2084971501 @default.
• W2069103615 cites W2093283271 @default.
• W2069103615 cites W2095474613 @default.
• W2069103615 cites W2102782790 @default.
• W2069103615 cites W2111962211 @default.
• W2069103615 cites W2113101214 @default.
• W2069103615 cites W2125561465 @default.
• W2069103615 cites W2148990197 @default.
• W2069103615 cites W2157111798 @default.
• W2069103615 cites W2158146782 @default.
• W2069103615 cites W2165819904 @default.
• W2069103615 cites W2793323124 @default.
• W2069103615 cites W4253705647 @default.
• W2069103615 doi "https://doi.org/10.1016/j.biocel.2013.04.030" @default.
• W2069103615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23702033" @default.
• W2069103615 hasPublicationYear "2013" @default.
• W2069103615 type Work @default.
• W2069103615 sameAs 2069103615 @default.
• W2069103615 citedByCount "29" @default.
• W2069103615 countsByYear W20691036152014 @default.
• W2069103615 countsByYear W20691036152015 @default.
• W2069103615 countsByYear W20691036152016 @default.
• W2069103615 countsByYear W20691036152017 @default.
• W2069103615 countsByYear W20691036152018 @default.
• W2069103615 countsByYear W20691036152019 @default.
• W2069103615 countsByYear W20691036152020 @default.
• W2069103615 countsByYear W20691036152021 @default.
• W2069103615 countsByYear W20691036152022 @default.
• W2069103615 countsByYear W20691036152023 @default.
• W2069103615 crossrefType "journal-article" @default.
• W2069103615 hasAuthorship W2069103615A5002705826 @default.
• W2069103615 hasAuthorship W2069103615A5002744113 @default.
• W2069103615 hasAuthorship W2069103615A5003128598 @default.
• W2069103615 hasAuthorship W2069103615A5031734558 @default.
• W2069103615 hasAuthorship W2069103615A5046605612 @default.
• W2069103615 hasAuthorship W2069103615A5058165407 @default.
• W2069103615 hasAuthorship W2069103615A5064466975 @default.
• W2069103615 hasAuthorship W2069103615A5076176069 @default.
• W2069103615 hasAuthorship W2069103615A5076251001 @default.
• W2069103615 hasAuthorship W2069103615A5077650477 @default.
• W2069103615 hasAuthorship W2069103615A5090494061 @default.
• W2069103615 hasConcept C123012128 @default.
• W2069103615 hasConcept C150903083 @default.
• W2069103615 hasConcept C185592680 @default.
• W2069103615 hasConcept C202751555 @default.
• W2069103615 hasConcept C207001950 @default.
• W2069103615 hasConcept C2780394083 @default.
• W2069103615 hasConcept C502942594 @default.
• W2069103615 hasConcept C55493867 @default.
• W2069103615 hasConcept C86803240 @default.
• W2069103615 hasConcept C95444343 @default.
• W2069103615 hasConcept C97230052 @default.
• W2069103615 hasConcept C98274493 @default.
• W2069103615 hasConceptScore W2069103615C123012128 @default.
• W2069103615 hasConceptScore W2069103615C150903083 @default.
• W2069103615 hasConceptScore W2069103615C185592680 @default.
• W2069103615 hasConceptScore W2069103615C202751555 @default.
• W2069103615 hasConceptScore W2069103615C207001950 @default.
• W2069103615 hasConceptScore W2069103615C2780394083 @default.
• W2069103615 hasConceptScore W2069103615C502942594 @default.
• W2069103615 hasConceptScore W2069103615C55493867 @default.
• W2069103615 hasConceptScore W2069103615C86803240 @default.
• W2069103615 hasConceptScore W2069103615C95444343 @default.

• next