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- W2069970638 abstract "Dendritic cells (DC) are the most important antigen presenting cells and play a pivotal role in host immunity to infectious agents by acting as a bridge between the innate and adaptive immune systems. Monocyte-derived immature DCs (iDC) were infected with viable resting conidia of Aspergillus fumigatus (Af293) for 12 hours at an MOI of 5; cells were sampled every three hours. RNA was extracted from both organisms at each time point and hybridised to microarrays. iDC cell death increased at 6 h in the presence of A. fumigatus which coincided with fungal germ tube emergence; >80% of conidia were associated with iDC. Over the time course A. fumigatus differentially regulated 210 genes, FunCat analysis indicated significant up-regulation of genes involved in fermentation, drug transport, pathogenesis and response to oxidative stress. Genes related to cytotoxicity were differentially regulated but the gliotoxin biosynthesis genes were down regulated over the time course, while Aspf1 was up-regulated at 9 h and 12 h. There was an up-regulation of genes in the subtelomeric regions of the genome as the interaction progressed. The genes up-regulated by iDC in the presence of A. fumigatus indicated that they were producing a pro-inflammatory response which was consistent with previous transcriptome studies of iDC interacting with A. fumigatus germ tubes. This study shows that A. fumigatus adapts to phagocytosis by iDCs by utilising genes that allow it to survive the interaction rather than just up-regulation of specific virulence genes." @default.
- W2069970638 created "2016-06-24" @default.
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- W2069970638 date "2011-01-14" @default.
- W2069970638 modified "2023-09-29" @default.
- W2069970638 title "The Temporal Dynamics of Differential Gene Expression in Aspergillus fumigatus Interacting with Human Immature Dendritic Cells In Vitro" @default.
- W2069970638 cites W1549715784 @default.
- W2069970638 cites W1600809398 @default.
- W2069970638 cites W1649649531 @default.
- W2069970638 cites W1964066906 @default.
- W2069970638 cites W1967583883 @default.
- W2069970638 cites W1979922016 @default.
- W2069970638 cites W1980921693 @default.
- W2069970638 cites W1985371834 @default.
- W2069970638 cites W1990161143 @default.
- W2069970638 cites W1993668738 @default.
- W2069970638 cites W1994663361 @default.
- W2069970638 cites W1998331436 @default.
- W2069970638 cites W1998735358 @default.
- W2069970638 cites W2012035078 @default.
- W2069970638 cites W2013039381 @default.
- W2069970638 cites W2013444425 @default.
- W2069970638 cites W2013869770 @default.
- W2069970638 cites W2015624992 @default.
- W2069970638 cites W2021215684 @default.
- W2069970638 cites W2024202925 @default.
- W2069970638 cites W2025725036 @default.
- W2069970638 cites W2027124691 @default.
- W2069970638 cites W2030862174 @default.
- W2069970638 cites W2032745168 @default.
- W2069970638 cites W2042775525 @default.
- W2069970638 cites W2045707837 @default.
- W2069970638 cites W2049221219 @default.
- W2069970638 cites W2054062172 @default.
- W2069970638 cites W2066731876 @default.
- W2069970638 cites W2068853695 @default.
- W2069970638 cites W2077180966 @default.
- W2069970638 cites W2080097192 @default.
- W2069970638 cites W2080507342 @default.
- W2069970638 cites W2084322890 @default.
- W2069970638 cites W2085469206 @default.
- W2069970638 cites W2085509368 @default.
- W2069970638 cites W2094245023 @default.
- W2069970638 cites W2099176294 @default.
- W2069970638 cites W2102671524 @default.
- W2069970638 cites W2103129929 @default.
- W2069970638 cites W2103740237 @default.
- W2069970638 cites W2103773924 @default.
- W2069970638 cites W2106364242 @default.
- W2069970638 cites W2107743627 @default.
- W2069970638 cites W2108313755 @default.
- W2069970638 cites W2108627308 @default.
- W2069970638 cites W2110271691 @default.
- W2069970638 cites W2111587762 @default.
- W2069970638 cites W2121691225 @default.
- W2069970638 cites W2121962352 @default.
- W2069970638 cites W2122598723 @default.
- W2069970638 cites W2122723390 @default.
- W2069970638 cites W2127938920 @default.
- W2069970638 cites W2134384685 @default.
- W2069970638 cites W2137221290 @default.
- W2069970638 cites W2137917513 @default.
- W2069970638 cites W2138296058 @default.
- W2069970638 cites W2139002656 @default.
- W2069970638 cites W2141197648 @default.
- W2069970638 cites W2142415307 @default.
- W2069970638 cites W2143989967 @default.
- W2069970638 cites W2145862280 @default.
- W2069970638 cites W2146052127 @default.
- W2069970638 cites W2147104869 @default.
- W2069970638 cites W2150885337 @default.
- W2069970638 cites W2152607354 @default.
- W2069970638 cites W2153506560 @default.
- W2069970638 cites W2153911335 @default.
- W2069970638 cites W2160697532 @default.
- W2069970638 cites W2162651779 @default.
- W2069970638 cites W2162817739 @default.
- W2069970638 cites W2164479064 @default.
- W2069970638 cites W2166781237 @default.
- W2069970638 cites W4239973039 @default.
- W2069970638 cites W4294107304 @default.
- W2069970638 cites W45534775 @default.
- W2069970638 doi "https://doi.org/10.1371/journal.pone.0016016" @default.
- W2069970638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3021540" @default.
- W2069970638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21264256" @default.
- W2069970638 hasPublicationYear "2011" @default.
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