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• W2070291446 startingPage "1089" @default.
• W2070291446 abstract "The effects of fencamfamine (FCF), an indirect dopamine (DA) agent, were investigated using the latent inhibition (LI) model of schizophrenia. In the LI procedure, rats preexposed (PE) to an unreinforced stimulus show difficulty in subsequent learning of an association in which that stimulus is predictive of an unconditioned stimulus (US). FCF (1.75, 3.5 and 7.0 mg/kg i.p.) yielded an inverse dose-response relationship regarding LI. At 3.5 mg/kg, LI was abolished and no effect was observed at 1.75 and 7.0 mg/kg. The effect of FCF (3.5 mg/kg) on LI was blocked by the antipsychotic risperidone (RIS; 4.0 mg/kg), a D2/5HT2 antagonist. These results confirm the similarity of the behavioral profile of FCF and amphetamine (AMPH). In addition, they provide a further validation of the LI model for psychosis, since RIS was shown to prevent a psychostimulant-induced disruption of LI." @default.
• W2070291446 created "2016-06-24" @default.
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• W2070291446 date "2002-10-01" @default.
• W2070291446 modified "2023-09-28" @default.
• W2070291446 title "Effects of fencamfamine on latent inhibition" @default.
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• W2070291446 doi "https://doi.org/10.1016/s0278-5846(02)00241-5" @default.
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