FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2070292028> ?p ?o ?g. }

• W2070292028 endingPage "72" @default.
• W2070292028 startingPage "63" @default.
• W2070292028 abstract "Gliomas, characterized by their progressively invasive phenotype, express integrin α3β1 as a major receptor for the extracellular matrix both in vivo and in vitro. Since the integrin α3β1 has been shown to be a specific receptor for laminin-5 (α3β3γ2), we examined the effects of purified human laminin-5 on adhesion, migration and invasion of human glioma cells. Among different types of laminin variants and other matrix proteins including fibronectin and vitronectin, laminin-5 was most potent in promoting adhesion and migration of different kinds of glioma cells. Laminin-5-mediated adhesion and migration were specifically inhibited by monoclonal antibodies against integrin α3 and β1 chains, confirming the role of integrin α3β1 as the major laminin-5 receptor. Invasion of the reconstituted basement membrane (i.e., Matrigel) by glioma cells was also selectively stimulated by laminin-5. Out results show that laminin-5 is the major extracellular stimulant for glioma cell adhesion, migration and invasion. The immunohistochemical distribution of laminin γ2 chain, a laminin subunit unique to laminin-5, showed that it was expressed in the tumor parenchyma of human glioma tissues. Expression of laminin α3, β3 and γ2 chains in glioma tissues and in glioma cell lines was also demonstrated at the messenger RNA level by reverse transcription polymerase chain reaction. Our results, taken together, show that laminin-5 may be involved in the invasive phenotype of malignant gliomas both in vitro and in vivo. Int. J. Cancer76:63–72, 1998.© 1998 Wiley-Liss, Inc." @default.
• W2070292028 created "2016-06-24" @default.
• W2070292028 creator A5005746298 @default.
• W2070292028 creator A5039674567 @default.
• W2070292028 creator A5042045948 @default.
• W2070292028 creator A5047256984 @default.
• W2070292028 creator A5069048507 @default.
• W2070292028 date "1998-03-30" @default.
• W2070292028 modified "2023-10-18" @default.
• W2070292028 title "Integrin α3β1-mediated interaction with laminin-5 stimulates adhesion, migration and invasion of malignant glioma cells" @default.
• W2070292028 cites W1952725897 @default.
• W2070292028 cites W1974405791 @default.
• W2070292028 cites W1974836258 @default.
• W2070292028 cites W1984591512 @default.
• W2070292028 cites W1985491088 @default.
• W2070292028 cites W1988835409 @default.
• W2070292028 cites W1996718671 @default.
• W2070292028 cites W2002453151 @default.
• W2070292028 cites W2020128511 @default.
• W2070292028 cites W2024604321 @default.
• W2070292028 cites W2035252564 @default.
• W2070292028 cites W2040651131 @default.
• W2070292028 cites W2046020327 @default.
• W2070292028 cites W2056862856 @default.
• W2070292028 cites W2062926268 @default.
• W2070292028 cites W2066279385 @default.
• W2070292028 cites W2075965099 @default.
• W2070292028 cites W2138316626 @default.
• W2070292028 cites W2154000442 @default.
• W2070292028 cites W2161140556 @default.
• W2070292028 cites W2166475130 @default.
• W2070292028 cites W2169606620 @default.
• W2070292028 doi "https://doi.org/10.1002/(sici)1097-0215(19980330)76:1<63::aid-ijc11>3.0.co;2-h" @default.
• W2070292028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9533763" @default.
• W2070292028 hasPublicationYear "1998" @default.
• W2070292028 type Work @default.
• W2070292028 sameAs 2070292028 @default.
• W2070292028 citedByCount "156" @default.
• W2070292028 countsByYear W20702920282012 @default.
• W2070292028 countsByYear W20702920282013 @default.
• W2070292028 countsByYear W20702920282014 @default.
• W2070292028 countsByYear W20702920282015 @default.
• W2070292028 countsByYear W20702920282017 @default.
• W2070292028 countsByYear W20702920282018 @default.
• W2070292028 countsByYear W20702920282019 @default.
• W2070292028 countsByYear W20702920282020 @default.
• W2070292028 countsByYear W20702920282021 @default.
• W2070292028 crossrefType "journal-article" @default.
• W2070292028 hasAuthorship W2070292028A5005746298 @default.
• W2070292028 hasAuthorship W2070292028A5039674567 @default.
• W2070292028 hasAuthorship W2070292028A5042045948 @default.
• W2070292028 hasAuthorship W2070292028A5047256984 @default.
• W2070292028 hasAuthorship W2070292028A5069048507 @default.
• W2070292028 hasConcept C1491633281 @default.
• W2070292028 hasConcept C153911025 @default.
• W2070292028 hasConcept C16224149 @default.
• W2070292028 hasConcept C164144092 @default.
• W2070292028 hasConcept C170493617 @default.
• W2070292028 hasConcept C189165786 @default.
• W2070292028 hasConcept C195687474 @default.
• W2070292028 hasConcept C2776193487 @default.
• W2070292028 hasConcept C2778227246 @default.
• W2070292028 hasConcept C2778608917 @default.
• W2070292028 hasConcept C2779814568 @default.
• W2070292028 hasConcept C2780394083 @default.
• W2070292028 hasConcept C502942594 @default.
• W2070292028 hasConcept C55493867 @default.
• W2070292028 hasConcept C85789140 @default.
• W2070292028 hasConcept C86492073 @default.
• W2070292028 hasConcept C86803240 @default.
• W2070292028 hasConcept C95444343 @default.
• W2070292028 hasConceptScore W2070292028C1491633281 @default.
• W2070292028 hasConceptScore W2070292028C153911025 @default.
• W2070292028 hasConceptScore W2070292028C16224149 @default.
• W2070292028 hasConceptScore W2070292028C164144092 @default.
• W2070292028 hasConceptScore W2070292028C170493617 @default.
• W2070292028 hasConceptScore W2070292028C189165786 @default.
• W2070292028 hasConceptScore W2070292028C195687474 @default.
• W2070292028 hasConceptScore W2070292028C2776193487 @default.
• W2070292028 hasConceptScore W2070292028C2778227246 @default.
• W2070292028 hasConceptScore W2070292028C2778608917 @default.
• W2070292028 hasConceptScore W2070292028C2779814568 @default.
• W2070292028 hasConceptScore W2070292028C2780394083 @default.
• W2070292028 hasConceptScore W2070292028C502942594 @default.
• W2070292028 hasConceptScore W2070292028C55493867 @default.
• W2070292028 hasConceptScore W2070292028C85789140 @default.
• W2070292028 hasConceptScore W2070292028C86492073 @default.
• W2070292028 hasConceptScore W2070292028C86803240 @default.
• W2070292028 hasConceptScore W2070292028C95444343 @default.
• W2070292028 hasIssue "1" @default.
• W2070292028 hasLocation W20702920281 @default.
• W2070292028 hasLocation W20702920282 @default.
• W2070292028 hasOpenAccess W2070292028 @default.
• W2070292028 hasPrimaryLocation W20702920281 @default.
• W2070292028 hasRelatedWork W1935625957 @default.
• W2070292028 hasRelatedWork W1958255860 @default.
• W2070292028 hasRelatedWork W1991991862 @default.
• W2070292028 hasRelatedWork W2026734109 @default.

• next