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• W2070292771 startingPage "263" @default.
• W2070292771 abstract "Prothoracicotropic hormone (PTTH) stimulates ecdysteroidogenesis in lepidopteran prothoracic glands (PGs), thus indirectly controlling molting and metamorphosis. PTTH triggers a signal transduction cascade in PGs that involves an early influx of Ca2+. Although the importance of Ca2+ has been long known, the mechanism(s) of PTTH-stimulated changes in cytoplasmic Ca2+ [Ca2+]i are not yet well understood. PGs from the fifth instar of Manduca sexta were exposed to PTTH in vitro. The resultant changes in [Ca2+]i were measured using ratiometric analysis of a fura-2 fluorescence signal in the presence and absence of inhibitors of specific cellular signaling mechanisms. The phospholipase C (PLC) inhibitor U-73122 nearly abolished the PTTH-stimulated increase in [Ca2+]i, as well as PTTH-stimulated ecdysteroidogenesis and extracellular-signal regulated kinase phosphorylation, thus establishing a role for PLC and implicating inositol trisphosphate (IP3) in PTTH signal transduction. Two antagonists of the IP3 receptor, 2-APB and TMB-8, likewise blocked the [Ca2+]i response by a mean of 92%. We describe for the first time the presence of Ca2+ oscillations in PTTH-stimulated cells in Ca2+-free medium. External Ca2+ entered PG cells via at least two routes: store-operated (capacitative) Ca2+ entry channels and L-type voltage-gated Ca2+ channels. We propose that PTTH initiates a transductory cascade typical of many G-protein coupled receptors, involving both Ca2+ mobilization and entry pathways." @default.
• W2070292771 created "2016-06-24" @default.
• W2070292771 creator A5018346235 @default.
• W2070292771 creator A5020125684 @default.
• W2070292771 creator A5057813286 @default.
• W2070292771 date "2005-04-01" @default.
• W2070292771 modified "2023-10-17" @default.
• W2070292771 title "Ca2+ signaling in prothoracicotropic hormone-stimulated prothoracic gland cells of Manduca sexta: Evidence for mobilization and entry mechanisms" @default.
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• W2070292771 doi "https://doi.org/10.1016/j.ibmb.2004.11.006" @default.
• W2070292771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15763463" @default.
• W2070292771 hasPublicationYear "2005" @default.
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