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- W2070293757 abstract "The global increase in the number of applications involving therapeutic plasmid DNA (pDNA) is creating a need for large amounts of highly stable and purified molecules. One of the main obstacles during the developmental stages of a new therapeutic DNA molecule involves tackling a wide array of structural instability events occurring in/with pDNA and therefore assuring its structural integrity. This review focuses on major instability determinants in pDNA. Their elimination could be considered an important step towards the design of safer and more efficient plasmid molecules. Particular emphasis is given to mutations triggered by the presence of repeated sequences, instability events occurring during plasmid intracellular routing, instability mediated by insertion sequences and host genome integration. The global increase in the number of applications involving therapeutic plasmid DNA (pDNA) is creating a need for large amounts of highly stable and purified molecules. One of the main obstacles during the developmental stages of a new therapeutic DNA molecule involves tackling a wide array of structural instability events occurring in/with pDNA and therefore assuring its structural integrity. This review focuses on major instability determinants in pDNA. Their elimination could be considered an important step towards the design of safer and more efficient plasmid molecules. Particular emphasis is given to mutations triggered by the presence of repeated sequences, instability events occurring during plasmid intracellular routing, instability mediated by insertion sequences and host genome integration." @default.
- W2070293757 created "2016-06-24" @default.
- W2070293757 creator A5003687327 @default.
- W2070293757 creator A5034588525 @default.
- W2070293757 creator A5068400044 @default.
- W2070293757 creator A5083507492 @default.
- W2070293757 date "2009-09-01" @default.
- W2070293757 modified "2023-09-25" @default.
- W2070293757 title "Structural instability of plasmid biopharmaceuticals: challenges and implications" @default.
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- W2070293757 doi "https://doi.org/10.1016/j.tibtech.2009.06.004" @default.
- W2070293757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19656584" @default.
- W2070293757 hasPublicationYear "2009" @default.
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