FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071110366> ?p ?o ?g. }

• W2071110366 endingPage "248" @default.
• W2071110366 startingPage "241" @default.
• W2071110366 abstract "Immunostimulatory CpG motifs have been implicated as a major contributor to the acute inflammatory response associated with nonviral vectors, most prominently seen after systemic delivery of cationic lipid-plasmid DNA (pDNA) complexes. We have shown previously that complexes containing pDNA vectors that have been largely depleted of CpG motifs have significantly reduced acute toxicity when delivered systemically. However, several CpGs remain in these vectors and the toxicity is not negligible, especially at higher doses of complex. To determine the maximal reduction in the acute toxic response that could be achieved by eliminating CpG signaling, we injected cationic lipid-pDNA complexes into transgenic mice that are deficient in Toll-like receptor 9 (TLR9), which is the receptor that recognizes immunostimulatory CpG motifs. We observed significantly decreased adverse hematological changes and liver damage in TLR9(-/-) mice compared to normal mice and increased survival at higher doses of complex. However, a pronounced loss of lymphocytes and platelets was still observed in the TLR9(-/-) mice at higher doses. We also measured the toxicity in normal mice of systemically delivered complexes containing non-CpG oligonucleotides. Although serum transaminase levels were reduced, a loss of lymphocytes and platelets akin to that seen in the TLR9(-/-) mice was observed. Taken together, these findings suggest that signaling through TLR9 contributes to the majority but not all of the toxic responses associated with systemic delivery of cationic lipid-pDNA complexes." @default.
• W2071110366 created "2016-06-24" @default.
• W2071110366 creator A5006597480 @default.
• W2071110366 creator A5018553332 @default.
• W2071110366 creator A5041655105 @default.
• W2071110366 creator A5053458425 @default.
• W2071110366 creator A5057984337 @default.
• W2071110366 creator A5079813508 @default.
• W2071110366 date "2004-02-01" @default.
• W2071110366 modified "2023-10-14" @default.
• W2071110366 title "Contribution of Toll-like Receptor 9 Signaling to the Acute Inflammatory Response to Nonviral Vectors" @default.
• W2071110366 cites W1514540900 @default.
• W2071110366 cites W1519633296 @default.
• W2071110366 cites W1521780742 @default.
• W2071110366 cites W1636901091 @default.
• W2071110366 cites W1655860314 @default.
• W2071110366 cites W1963440056 @default.
• W2071110366 cites W1963648622 @default.
• W2071110366 cites W1991190678 @default.
• W2071110366 cites W1999461960 @default.
• W2071110366 cites W2004773897 @default.
• W2071110366 cites W2012519514 @default.
• W2071110366 cites W2016862474 @default.
• W2071110366 cites W2021693767 @default.
• W2071110366 cites W2029175314 @default.
• W2071110366 cites W2030672230 @default.
• W2071110366 cites W2036110284 @default.
• W2071110366 cites W2040282775 @default.
• W2071110366 cites W2040865916 @default.
• W2071110366 cites W2047366876 @default.
• W2071110366 cites W2064330002 @default.
• W2071110366 cites W2069240580 @default.
• W2071110366 cites W2069981713 @default.
• W2071110366 cites W2076361525 @default.
• W2071110366 cites W2085795202 @default.
• W2071110366 cites W2088223086 @default.
• W2071110366 cites W2092128665 @default.
• W2071110366 cites W2099361600 @default.
• W2071110366 cites W2145118219 @default.
• W2071110366 cites W2173816134 @default.
• W2071110366 cites W2313525748 @default.
• W2071110366 cites W2314516700 @default.
• W2071110366 cites W2316948580 @default.
• W2071110366 cites W2318823488 @default.
• W2071110366 cites W2328277731 @default.
• W2071110366 cites W2417842909 @default.
• W2071110366 cites W4313341466 @default.
• W2071110366 doi "https://doi.org/10.1016/j.ymthe.2003.11.012" @default.
• W2071110366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14759808" @default.
• W2071110366 hasPublicationYear "2004" @default.
• W2071110366 type Work @default.
• W2071110366 sameAs 2071110366 @default.
• W2071110366 citedByCount "81" @default.
• W2071110366 countsByYear W20711103662012 @default.
• W2071110366 countsByYear W20711103662013 @default.
• W2071110366 countsByYear W20711103662014 @default.
• W2071110366 countsByYear W20711103662015 @default.
• W2071110366 countsByYear W20711103662016 @default.
• W2071110366 countsByYear W20711103662017 @default.
• W2071110366 countsByYear W20711103662018 @default.
• W2071110366 countsByYear W20711103662019 @default.
• W2071110366 countsByYear W20711103662020 @default.
• W2071110366 countsByYear W20711103662021 @default.
• W2071110366 countsByYear W20711103662022 @default.
• W2071110366 countsByYear W20711103662023 @default.
• W2071110366 crossrefType "journal-article" @default.
• W2071110366 hasAuthorship W2071110366A5006597480 @default.
• W2071110366 hasAuthorship W2071110366A5018553332 @default.
• W2071110366 hasAuthorship W2071110366A5041655105 @default.
• W2071110366 hasAuthorship W2071110366A5053458425 @default.
• W2071110366 hasAuthorship W2071110366A5057984337 @default.
• W2071110366 hasAuthorship W2071110366A5079813508 @default.
• W2071110366 hasBestOaLocation W20711103661 @default.
• W2071110366 hasConcept C104317684 @default.
• W2071110366 hasConcept C140173407 @default.
• W2071110366 hasConcept C150194340 @default.
• W2071110366 hasConcept C150903083 @default.
• W2071110366 hasConcept C153911025 @default.
• W2071110366 hasConcept C170493617 @default.
• W2071110366 hasConcept C178790620 @default.
• W2071110366 hasConcept C185592680 @default.
• W2071110366 hasConcept C190727270 @default.
• W2071110366 hasConcept C203014093 @default.
• W2071110366 hasConcept C207001950 @default.
• W2071110366 hasConcept C22801619 @default.
• W2071110366 hasConcept C25938499 @default.
• W2071110366 hasConcept C2776914184 @default.
• W2071110366 hasConcept C2779138994 @default.
• W2071110366 hasConcept C29730261 @default.
• W2071110366 hasConcept C54009773 @default.
• W2071110366 hasConcept C55493867 @default.
• W2071110366 hasConcept C86803240 @default.
• W2071110366 hasConcept C89560881 @default.
• W2071110366 hasConcept C95444343 @default.
• W2071110366 hasConceptScore W2071110366C104317684 @default.
• W2071110366 hasConceptScore W2071110366C140173407 @default.
• W2071110366 hasConceptScore W2071110366C150194340 @default.
• W2071110366 hasConceptScore W2071110366C150903083 @default.

• next