FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2071523786> ?p ?o ?g. }

• W2071523786 endingPage "205" @default.
• W2071523786 startingPage "195" @default.
• W2071523786 abstract "Human breast cancer cells with a CD44(+)/CD24(-/low) or ALDH1+ phenotype have been demonstrated to be enriched for cancer stem cells (CSCs) using in vitro and in vivo techniques. The aim of this study was to determine the association between CD44(+)/CD24(-/low) and ALDH1 expression with clinical-pathologic tumor characteristics, tumor molecular subtype, and survival in a well characterized collection of familial breast cancer cases. 364 familial breast cancers from the Ontario Familial Breast Cancer Registry (58 BRCA1-associated, 64 BRCA2-associated, and 242 familial non-BRCA1/2 cancers) were studied. Each tumor had a centralized pathology review performed. TMA sections of all tumors were analyzed for the expression of ER, PR, HER2, CK5, CK14, EGFR, CD44, CD24, and ALDH1. The Chi square test or Fisher's exact test was used to analyze the marker associations with clinical-pathologic tumor variables, molecular subtype and genetic subtype. Analyses of the association of overall survival (OS) with marker status were conducted using Kaplan-Meier plots and log-rank tests. The CD44(+)/CD24(-/low) and ALDH1+ phenotypes were identified in 16% and 15% of the familial breast cancer cases, respectively, and associated with high-tumor grade, a high-mitotic count, and component features of the medullary type of breast cancer. CD44(+)/CD24(-/low) and ALDH1 expression in this series were further associated with the basal-like molecular subtype and the CD44(+)/CD24(-/low) phenotype was independently associated with BRCA1 mutational status. The currently accepted breast CSCs markers are present in a minority of familial breast cancers. Whereas the presence of these markers is correlated with several poor prognostic features and the basal-like subtype of breast cancer, they do not predict OS." @default.
• W2071523786 created "2016-06-24" @default.
• W2071523786 creator A5014049385 @default.
• W2071523786 creator A5018738783 @default.
• W2071523786 creator A5039135644 @default.
• W2071523786 creator A5049688231 @default.
• W2071523786 creator A5051193305 @default.
• W2071523786 creator A5053066022 @default.
• W2071523786 date "2013-06-28" @default.
• W2071523786 modified "2023-10-16" @default.
• W2071523786 title "Clinical–pathologic significance of cancer stem cell marker expression in familial breast cancers" @default.
• W2071523786 cites W1522435592 @default.
• W2071523786 cites W1892496998 @default.
• W2071523786 cites W1967041337 @default.
• W2071523786 cites W1976428492 @default.
• W2071523786 cites W1985585224 @default.
• W2071523786 cites W1985748412 @default.
• W2071523786 cites W1997280228 @default.
• W2071523786 cites W1997316363 @default.
• W2071523786 cites W1997688669 @default.
• W2071523786 cites W1999150128 @default.
• W2071523786 cites W2001144553 @default.
• W2071523786 cites W2001436780 @default.
• W2071523786 cites W2009098155 @default.
• W2071523786 cites W2010871781 @default.
• W2071523786 cites W2013546397 @default.
• W2071523786 cites W2020913453 @default.
• W2071523786 cites W2022205756 @default.
• W2071523786 cites W2023316892 @default.
• W2071523786 cites W2023427658 @default.
• W2071523786 cites W2032992855 @default.
• W2071523786 cites W2037066451 @default.
• W2071523786 cites W2039135884 @default.
• W2071523786 cites W2039167351 @default.
• W2071523786 cites W2044459640 @default.
• W2071523786 cites W2044692335 @default.
• W2071523786 cites W2050300062 @default.
• W2071523786 cites W2053122486 @default.
• W2071523786 cites W2054541267 @default.
• W2071523786 cites W2058935670 @default.
• W2071523786 cites W2061464560 @default.
• W2071523786 cites W2067199269 @default.
• W2071523786 cites W2069697412 @default.
• W2071523786 cites W2071167287 @default.
• W2071523786 cites W2077702574 @default.
• W2071523786 cites W2082326948 @default.
• W2071523786 cites W2093742746 @default.
• W2071523786 cites W2095156669 @default.
• W2071523786 cites W2097255042 @default.
• W2071523786 cites W2099335989 @default.
• W2071523786 cites W2099797262 @default.
• W2071523786 cites W2105504936 @default.
• W2071523786 cites W2106292881 @default.
• W2071523786 cites W2106619332 @default.
• W2071523786 cites W2107380545 @default.
• W2071523786 cites W2112241022 @default.
• W2071523786 cites W2118758371 @default.
• W2071523786 cites W2123665978 @default.
• W2071523786 cites W2124924712 @default.
• W2071523786 cites W2130849876 @default.
• W2071523786 cites W2131994307 @default.
• W2071523786 cites W2133341870 @default.
• W2071523786 cites W2133349592 @default.
• W2071523786 cites W2135548733 @default.
• W2071523786 cites W2136178883 @default.
• W2071523786 cites W2137102640 @default.
• W2071523786 cites W2137162822 @default.
• W2071523786 cites W2137586381 @default.
• W2071523786 cites W2137715553 @default.
• W2071523786 cites W2138240181 @default.
• W2071523786 cites W2142491513 @default.
• W2071523786 cites W2142630052 @default.
• W2071523786 cites W2142709970 @default.
• W2071523786 cites W2143383125 @default.
• W2071523786 cites W2147343434 @default.
• W2071523786 cites W2147787153 @default.
• W2071523786 cites W2148320927 @default.
• W2071523786 cites W2154705528 @default.
• W2071523786 cites W2155390148 @default.
• W2071523786 cites W2156604663 @default.
• W2071523786 cites W2156624320 @default.
• W2071523786 cites W2157840751 @default.
• W2071523786 cites W2158627893 @default.
• W2071523786 cites W2159640574 @default.
• W2071523786 cites W2160298696 @default.
• W2071523786 cites W2163292580 @default.
• W2071523786 cites W2164817306 @default.
• W2071523786 cites W2166247816 @default.
• W2071523786 cites W2169752217 @default.
• W2071523786 cites W2288763477 @default.
• W2071523786 cites W2762697978 @default.
• W2071523786 doi "https://doi.org/10.1007/s10549-013-2591-1" @default.
• W2071523786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3706716" @default.
• W2071523786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23813303" @default.
• W2071523786 hasPublicationYear "2013" @default.
• W2071523786 type Work @default.
• W2071523786 sameAs 2071523786 @default.
• W2071523786 citedByCount "37" @default.

• next