FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073436302> ?p ?o ?g. }

• W2073436302 endingPage "49" @default.
• W2073436302 startingPage "39" @default.
• W2073436302 abstract "<em>Tityus serrulatus</em> scorpion venom (TSV) consists of a very complex mixture of molecules and demonstrates significant immunomodulatory activities capable of stimulating immune functions in vivo. The purpose of this study was to compare the crude TSV with fractionated toxins extracted from this venom in order to determine which toxin(s) presented immunomodulatory effects on peritoneal macrophages. TSV was fractionated using gel filtration chromatography resulting in 5 heterogeneous fractions. The effects of these different fractions were analysed in vitro using detection by means of cytokines, oxygen intermediate metabolites (<mml:math alttext=$H_{2}O_{2}$ xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msub><mml:mtext>H</mml:mtext><mml:mtext>2</mml:mtext></mml:msub><mml:msub><mml:mtext>O</mml:mtext><mml:mtext>2</mml:mtext></mml:msub></mml:math>), and nitric oxide (<mml:math alttext=NO xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mtext>NO</mml:mtext></mml:math>) in supernatants of peritoneal macrophages. Several functional bioassays were employed: tumor necrosis factor (TNF) activity was assayed by measuring its cytotoxic activity in L929 cells, and other cytokines were assayed by enzyme-linked immunosorbent assay, whereas <mml:math alttext=NO xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mtext>NO</mml:mtext></mml:math> levels were detected by Griess colorimetric reactions in culture supernatant of macrophages exposed to different fractions. In vitro studies revealed that all fractions studied here presented an increment in <mml:math alttext=$H_{2}O_{2}$ xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:msub><mml:mtext>H</mml:mtext><mml:mtext>2</mml:mtext></mml:msub><mml:msub><mml:mtext>O</mml:mtext><mml:mtext>2</mml:mtext></mml:msub></mml:math>, <mml:math alttext=NO xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mtext>NO</mml:mtext></mml:math>, and cytokines levels. The more pronounced increments were observed in macrophage cultures exposed to fraction FII which demonstrated that (a) the highest levels of IL-1<mml:math alttext=$alpha$ xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>&#945;</mml:mi></mml:math>, IL-<mml:math alttext=$beta$ xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>&#946;</mml:mi></mml:math>, and TNF were observed after 12 hours and that (b) the maximum levels of IFN-<mml:math alttext=$gamma$ xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>&#947;</mml:mi></mml:math> and <mml:math alttext=NO xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mtext>NO</mml:mtext></mml:math> were observed after 72 hours. Taken together, these data indicate that fractions have a differential immunomodulating effect on macrophage secretion, and that FII is a potent activator of TNF production of macrophages." @default.
• W2073436302 created "2016-06-24" @default.
• W2073436302 creator A5031352542 @default.
• W2073436302 creator A5040893228 @default.
• W2073436302 date "2005-01-01" @default.
• W2073436302 modified "2023-10-12" @default.
• W2073436302 title "Immunomodulatory Effects of the Tityus serrulatus Venom on Murine Macrophage Functions in Vitro" @default.
• W2073436302 cites W1515994079 @default.
• W2073436302 cites W1551592047 @default.
• W2073436302 cites W1558096813 @default.
• W2073436302 cites W1572295857 @default.
• W2073436302 cites W1633041824 @default.
• W2073436302 cites W1856702249 @default.
• W2073436302 cites W1917885463 @default.
• W2073436302 cites W1963492254 @default.
• W2073436302 cites W1968876368 @default.
• W2073436302 cites W1969222632 @default.
• W2073436302 cites W1970388960 @default.
• W2073436302 cites W1973018387 @default.
• W2073436302 cites W1973170537 @default.
• W2073436302 cites W1973453969 @default.
• W2073436302 cites W1973975275 @default.
• W2073436302 cites W1974447707 @default.
• W2073436302 cites W1980482622 @default.
• W2073436302 cites W1987899402 @default.
• W2073436302 cites W2008964357 @default.
• W2073436302 cites W2013340592 @default.
• W2073436302 cites W2013824064 @default.
• W2073436302 cites W2023406821 @default.
• W2073436302 cites W2037382552 @default.
• W2073436302 cites W2059441193 @default.
• W2073436302 cites W2059517501 @default.
• W2073436302 cites W2065209336 @default.
• W2073436302 cites W2071566549 @default.
• W2073436302 cites W2072186147 @default.
• W2073436302 cites W2074387820 @default.
• W2073436302 cites W2080855671 @default.
• W2073436302 cites W2084129051 @default.
• W2073436302 cites W2092307414 @default.
• W2073436302 cites W2133354596 @default.
• W2073436302 cites W2139535814 @default.
• W2073436302 cites W2154746915 @default.
• W2073436302 cites W2155479242 @default.
• W2073436302 cites W2164392688 @default.
• W2073436302 cites W2181594845 @default.
• W2073436302 cites W2238405015 @default.
• W2073436302 cites W2277960607 @default.
• W2073436302 cites W2397182206 @default.
• W2073436302 cites W4233965061 @default.
• W2073436302 doi "https://doi.org/10.1155/mi.2005.39" @default.
• W2073436302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1513058" @default.
• W2073436302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15770065" @default.
• W2073436302 hasPublicationYear "2005" @default.
• W2073436302 type Work @default.
• W2073436302 sameAs 2073436302 @default.
• W2073436302 citedByCount "34" @default.
• W2073436302 countsByYear W20734363022012 @default.
• W2073436302 countsByYear W20734363022013 @default.
• W2073436302 countsByYear W20734363022014 @default.
• W2073436302 countsByYear W20734363022015 @default.
• W2073436302 countsByYear W20734363022016 @default.
• W2073436302 countsByYear W20734363022018 @default.
• W2073436302 countsByYear W20734363022019 @default.
• W2073436302 countsByYear W20734363022021 @default.
• W2073436302 countsByYear W20734363022022 @default.
• W2073436302 countsByYear W20734363022023 @default.
• W2073436302 crossrefType "journal-article" @default.
• W2073436302 hasAuthorship W2073436302A5031352542 @default.
• W2073436302 hasAuthorship W2073436302A5040893228 @default.
• W2073436302 hasBestOaLocation W20734363021 @default.
• W2073436302 hasConcept C150903083 @default.
• W2073436302 hasConcept C17991360 @default.
• W2073436302 hasConcept C185592680 @default.
• W2073436302 hasConcept C202751555 @default.
• W2073436302 hasConcept C203014093 @default.
• W2073436302 hasConcept C207001950 @default.
• W2073436302 hasConcept C2779448229 @default.
• W2073436302 hasConcept C43617362 @default.
• W2073436302 hasConcept C55493867 @default.
• W2073436302 hasConcept C86803240 @default.
• W2073436302 hasConceptScore W2073436302C150903083 @default.
• W2073436302 hasConceptScore W2073436302C17991360 @default.
• W2073436302 hasConceptScore W2073436302C185592680 @default.
• W2073436302 hasConceptScore W2073436302C202751555 @default.
• W2073436302 hasConceptScore W2073436302C203014093 @default.
• W2073436302 hasConceptScore W2073436302C207001950 @default.
• W2073436302 hasConceptScore W2073436302C2779448229 @default.
• W2073436302 hasConceptScore W2073436302C43617362 @default.
• W2073436302 hasConceptScore W2073436302C55493867 @default.
• W2073436302 hasConceptScore W2073436302C86803240 @default.
• W2073436302 hasIssue "1" @default.
• W2073436302 hasLocation W20734363021 @default.
• W2073436302 hasLocation W20734363022 @default.
• W2073436302 hasLocation W20734363023 @default.
• W2073436302 hasLocation W20734363024 @default.
• W2073436302 hasOpenAccess W2073436302 @default.
• W2073436302 hasPrimaryLocation W20734363021 @default.
• W2073436302 hasRelatedWork W1566729005 @default.

• next