FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073669043> ?p ?o ?g. }

• W2073669043 endingPage "46" @default.
• W2073669043 startingPage "39" @default.
• W2073669043 abstract "The purpose of this study was to investigate the depression of the glass transition temperature, T(g), of the protease inhibitor saquinavir in the first heating scan as a function of the quantity of sorbed water by the application of modulated temperature differential scanning calorimetry (MTDSC). Samples of amorphous saquinavir were pretreated under various humidity conditions and the quantity of sorbed water measured by thermogravimetric analysis. MTDSC runs were performed using hermetically and non-hermetically sealed pans in order to determine the glass transition temperature. MTDSC allowed the separation of the glass transition from the enthalpic relaxation, thereby allowing clear visualisation of T(g) for amorphous saquinavir in the first heating scan. The plasticizing effects of water were assessed, with the depression in T(g) related to the mole fraction of water sorbed via the Gordon-Taylor relationship. An expression has been derived which allows estimation of the water content which lowers the T(g) to the storage temperature, thereby considerably increasing the risk of recrystallisation. It is argued that this model may aid prediction of the optimal storage conditions for amorphous drugs." @default.
• W2073669043 created "2016-06-24" @default.
• W2073669043 creator A5027838416 @default.
• W2073669043 creator A5045425376 @default.
• W2073669043 creator A5048211523 @default.
• W2073669043 date "1999-12-01" @default.
• W2073669043 modified "2023-10-17" @default.
• W2073669043 title "Characterisation of moisture uptake effects on the glass transitional behaviour of an amorphous drug using modulated temperature DSC" @default.
• W2073669043 cites W1564900557 @default.
• W2073669043 cites W1788548603 @default.
• W2073669043 cites W1834585315 @default.
• W2073669043 cites W1987451124 @default.
• W2073669043 cites W2013133034 @default.
• W2073669043 cites W2023550573 @default.
• W2073669043 cites W2047948690 @default.
• W2073669043 cites W2070556457 @default.
• W2073669043 cites W2073352795 @default.
• W2073669043 cites W2074610153 @default.
• W2073669043 cites W2075179133 @default.
• W2073669043 cites W2088157214 @default.
• W2073669043 cites W2102110206 @default.
• W2073669043 cites W59183630 @default.
• W2073669043 doi "https://doi.org/10.1016/s0378-5173(99)00270-7" @default.
• W2073669043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10572197" @default.
• W2073669043 hasPublicationYear "1999" @default.
• W2073669043 type Work @default.
• W2073669043 sameAs 2073669043 @default.
• W2073669043 citedByCount "38" @default.
• W2073669043 countsByYear W20736690432012 @default.
• W2073669043 countsByYear W20736690432013 @default.
• W2073669043 countsByYear W20736690432014 @default.
• W2073669043 countsByYear W20736690432015 @default.
• W2073669043 countsByYear W20736690432016 @default.
• W2073669043 countsByYear W20736690432017 @default.
• W2073669043 countsByYear W20736690432018 @default.
• W2073669043 countsByYear W20736690432019 @default.
• W2073669043 countsByYear W20736690432021 @default.
• W2073669043 countsByYear W20736690432023 @default.
• W2073669043 crossrefType "journal-article" @default.
• W2073669043 hasAuthorship W2073669043A5027838416 @default.
• W2073669043 hasAuthorship W2073669043A5045425376 @default.
• W2073669043 hasAuthorship W2073669043A5048211523 @default.
• W2073669043 hasConcept C113196181 @default.
• W2073669043 hasConcept C121332964 @default.
• W2073669043 hasConcept C122865956 @default.
• W2073669043 hasConcept C127413603 @default.
• W2073669043 hasConcept C142462285 @default.
• W2073669043 hasConcept C159985019 @default.
• W2073669043 hasConcept C178790620 @default.
• W2073669043 hasConcept C185592680 @default.
• W2073669043 hasConcept C192562407 @default.
• W2073669043 hasConcept C199289684 @default.
• W2073669043 hasConcept C2776937687 @default.
• W2073669043 hasConcept C2993143319 @default.
• W2073669043 hasConcept C3013748606 @default.
• W2073669043 hasConcept C39519442 @default.
• W2073669043 hasConcept C42360764 @default.
• W2073669043 hasConcept C512399662 @default.
• W2073669043 hasConcept C521977710 @default.
• W2073669043 hasConcept C56052488 @default.
• W2073669043 hasConcept C60100273 @default.
• W2073669043 hasConcept C71924100 @default.
• W2073669043 hasConcept C97355855 @default.
• W2073669043 hasConceptScore W2073669043C113196181 @default.
• W2073669043 hasConceptScore W2073669043C121332964 @default.
• W2073669043 hasConceptScore W2073669043C122865956 @default.
• W2073669043 hasConceptScore W2073669043C127413603 @default.
• W2073669043 hasConceptScore W2073669043C142462285 @default.
• W2073669043 hasConceptScore W2073669043C159985019 @default.
• W2073669043 hasConceptScore W2073669043C178790620 @default.
• W2073669043 hasConceptScore W2073669043C185592680 @default.
• W2073669043 hasConceptScore W2073669043C192562407 @default.
• W2073669043 hasConceptScore W2073669043C199289684 @default.
• W2073669043 hasConceptScore W2073669043C2776937687 @default.
• W2073669043 hasConceptScore W2073669043C2993143319 @default.
• W2073669043 hasConceptScore W2073669043C3013748606 @default.
• W2073669043 hasConceptScore W2073669043C39519442 @default.
• W2073669043 hasConceptScore W2073669043C42360764 @default.
• W2073669043 hasConceptScore W2073669043C512399662 @default.
• W2073669043 hasConceptScore W2073669043C521977710 @default.
• W2073669043 hasConceptScore W2073669043C56052488 @default.
• W2073669043 hasConceptScore W2073669043C60100273 @default.
• W2073669043 hasConceptScore W2073669043C71924100 @default.
• W2073669043 hasConceptScore W2073669043C97355855 @default.
• W2073669043 hasIssue "1" @default.
• W2073669043 hasLocation W20736690431 @default.
• W2073669043 hasLocation W20736690432 @default.
• W2073669043 hasOpenAccess W2073669043 @default.
• W2073669043 hasPrimaryLocation W20736690431 @default.
• W2073669043 hasRelatedWork W1269781246 @default.
• W2073669043 hasRelatedWork W1981590297 @default.
• W2073669043 hasRelatedWork W2001173300 @default.
• W2073669043 hasRelatedWork W2003303160 @default.
• W2073669043 hasRelatedWork W2060679680 @default.
• W2073669043 hasRelatedWork W2082488952 @default.
• W2073669043 hasRelatedWork W2106179355 @default.
• W2073669043 hasRelatedWork W220125326 @default.
• W2073669043 hasRelatedWork W2362964961 @default.

• next