FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2073669650> ?p ?o ?g. }

• W2073669650 abstract "Amniotic fluid-derived stem cells (AFSCs) are a unique stem cell source that may have great potential for use in tissue engineering (TE) due to their pluripotentiality. AFSCs have previously shown angiogenic potential and may present an alternative cell source for endothelial-like cells that could be used in range of applications, including the pre-vascularisation of TE constructs and the treatment of ischaemic diseases. This study investigated the ability of these cells to differentiate down an endothelial lineage with the aim of producing an endothelial-like cell suitable for use in pre-vascularisation. As hypoxia and the associated HIF-1 pathway have been implicated in the induction of angiogenesis in a number of biological processes, it was hypothesised that culture in hypoxic conditions could enhance the endothelial differentiation of AFSCs. The cells were cultured in endothelial cell media supplemented with 50 ng mL(-1) of VEGF, maintained in normoxia, intermittent hypoxia or continuous hypoxia and assessed for markers of endothelial differentiation at day 7 and 14. The results demonstrated that AFSCs subjected to these culture conditions display an endothelial gene expression profile and adopted functional endothelial cell characteristics indicative of early endothelial differentiation. Culture in continuous hypoxia enhanced endothelial gene expression but did not enhance functional endothelial cell characteristics. Overall, AFSCs subjected to endothelial stimuli demonstrated a less mature endothelial gene expression profile and phenotype when compared with HUVECs, the endothelial cell control. However, this study is the first time that the positive effect of an extended period of continuous hypoxic culture on endothelial differentiation in AFSCs has been demonstrated." @default.
• W2073669650 created "2016-06-24" @default.
• W2073669650 creator A5007435119 @default.
• W2073669650 creator A5023750865 @default.
• W2073669650 creator A5055855804 @default.
• W2073669650 date "2015-03-31" @default.
• W2073669650 modified "2023-09-24" @default.
• W2073669650 title "Investigating the effect of hypoxic culture on the endothelial differentiation of human amniotic fluid-derived stem cells" @default.
• W2073669650 cites W1857298428 @default.
• W2073669650 cites W1965378998 @default.
• W2073669650 cites W1965853505 @default.
• W2073669650 cites W1975111290 @default.
• W2073669650 cites W1975280273 @default.
• W2073669650 cites W1977947034 @default.
• W2073669650 cites W1978506033 @default.
• W2073669650 cites W1981360146 @default.
• W2073669650 cites W1982464856 @default.
• W2073669650 cites W1988403143 @default.
• W2073669650 cites W1991144246 @default.
• W2073669650 cites W1995185323 @default.
• W2073669650 cites W1997168440 @default.
• W2073669650 cites W1997254182 @default.
• W2073669650 cites W2001878818 @default.
• W2073669650 cites W2010391708 @default.
• W2073669650 cites W2011236887 @default.
• W2073669650 cites W2013297672 @default.
• W2073669650 cites W2014216753 @default.
• W2073669650 cites W2014352921 @default.
• W2073669650 cites W2014644717 @default.
• W2073669650 cites W2017984588 @default.
• W2073669650 cites W2018289835 @default.
• W2073669650 cites W2024436226 @default.
• W2073669650 cites W2026281091 @default.
• W2073669650 cites W2035582618 @default.
• W2073669650 cites W2037237480 @default.
• W2073669650 cites W203820675 @default.
• W2073669650 cites W2039667504 @default.
• W2073669650 cites W2052371470 @default.
• W2073669650 cites W2057896668 @default.
• W2073669650 cites W2060707687 @default.
• W2073669650 cites W2061814847 @default.
• W2073669650 cites W2073689026 @default.
• W2073669650 cites W2075942568 @default.
• W2073669650 cites W2077656376 @default.
• W2073669650 cites W2080342412 @default.
• W2073669650 cites W2093927588 @default.
• W2073669650 cites W2098400443 @default.
• W2073669650 cites W2098972920 @default.
• W2073669650 cites W2100837269 @default.
• W2073669650 cites W2107277218 @default.
• W2073669650 cites W2114331080 @default.
• W2073669650 cites W2117904914 @default.
• W2073669650 cites W2121390857 @default.
• W2073669650 cites W2130639482 @default.
• W2073669650 cites W2134082960 @default.
• W2073669650 cites W2137612350 @default.
• W2073669650 cites W2141046053 @default.
• W2073669650 cites W2141171507 @default.
• W2073669650 cites W2143035259 @default.
• W2073669650 cites W2149507412 @default.
• W2073669650 cites W2154999175 @default.
• W2073669650 cites W2155046952 @default.
• W2073669650 cites W2159348812 @default.
• W2073669650 cites W2163069245 @default.
• W2073669650 cites W2165438231 @default.
• W2073669650 cites W2171974810 @default.
• W2073669650 cites W2295763141 @default.
• W2073669650 cites W2883854607 @default.
• W2073669650 cites W3259491 @default.
• W2073669650 cites W4238927690 @default.
• W2073669650 cites W94996060 @default.
• W2073669650 cites W1964184380 @default.
• W2073669650 doi "https://doi.org/10.1111/joa.12283" @default.
• W2073669650 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4694115" @default.
• W2073669650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25833670" @default.
• W2073669650 hasPublicationYear "2015" @default.
• W2073669650 type Work @default.
• W2073669650 sameAs 2073669650 @default.
• W2073669650 citedByCount "6" @default.
• W2073669650 countsByYear W20736696502015 @default.
• W2073669650 countsByYear W20736696502016 @default.
• W2073669650 countsByYear W20736696502019 @default.
• W2073669650 countsByYear W20736696502020 @default.
• W2073669650 crossrefType "journal-article" @default.
• W2073669650 hasAuthorship W2073669650A5007435119 @default.
• W2073669650 hasAuthorship W2073669650A5023750865 @default.
• W2073669650 hasAuthorship W2073669650A5055855804 @default.
• W2073669650 hasBestOaLocation W20736696501 @default.
• W2073669650 hasConcept C104317684 @default.
• W2073669650 hasConcept C123012128 @default.
• W2073669650 hasConcept C148738053 @default.
• W2073669650 hasConcept C172680121 @default.
• W2073669650 hasConcept C178790620 @default.
• W2073669650 hasConcept C185592680 @default.
• W2073669650 hasConcept C201750760 @default.
• W2073669650 hasConcept C202751555 @default.
• W2073669650 hasConcept C203014093 @default.
• W2073669650 hasConcept C2776992346 @default.
• W2073669650 hasConcept C2778194526 @default.
• W2073669650 hasConcept C2779234561 @default.

• next