FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074001658> ?p ?o ?g. }

• W2074001658 abstract "Abstract Background Regeneration of neurons and fibers in the mammalian spinal cord has not been plausible, even though extensive studies have been made to understand the restrictive factors involved. New experimental models and strategies are necessary to determine how new nerve cells are generated and how fibers regrow and connect with their targets in adult animals. Non-vertebrate deuterostomes might provide some answers to these questions. Echinoderms, with their amazing regenerative capacities could serve as model systems; however, very few studies have been done to study the regeneration of their nervous system. Results We have studied nerve cord regeneration in the echinoderm Holothuria glaberrima . These are sea cucumbers or holothurians members of the class Holothuroidea. One radial nerve cord, part of the echinoderm CNS, was completely transected using a scalpel blade. Animals were allowed to heal for up to four weeks (2, 6, 12, 20, and 28 days post-injury) before sacrificed. Tissues were sectioned in a cryostat and changes in the radial nerve cord were analyzed using classical dyes and immmuohistochemistry. In addition, the temporal and spatial distribution of cell proliferation and apoptosis was assayed using BrdU incorporation and the TUNEL assay, respectively. We found that H. glaberrima can regenerate its radial nerve cord within a month following transection. The regenerated cord looks amazingly similar in overall morphology and cellular composition to the uninjured cord. The cellular events associated to radial cord regeneration include: (1) outgrowth of nerve fibers from the injured radial cord stumps, (2) intense cellular division in the cord stumps and in the regenerating radial nerve cords, (3) high levels of apoptosis in the RNC adjacent to the injury and within the regenerating cord and (4) an increase in the number of spherule-containing cells. These events are similar to those that occur in other body wall tissues during wound healing and during regeneration of the intestine. Conclusion Our data indicate that holothurians are capable of rapid and complete regeneration of the main component of their CNS. Regeneration involves both the outgrowth of nerve fibers and the formation of neurons. Moreover, the cellular events employed during regeneration are similar to those involved in other regenerative processes, namely wound healing and intestinal regeneration. Thus, holothurians should be viewed as an alternative model where many of the questions regarding nervous system regeneration in deuterostomes could be answered." @default.
• W2074001658 created "2016-06-24" @default.
• W2074001658 creator A5021386393 @default.
• W2074001658 creator A5066083022 @default.
• W2074001658 creator A5091462673 @default.
• W2074001658 date "2009-01-06" @default.
• W2074001658 modified "2023-10-13" @default.
• W2074001658 title "Regeneration of the radial nerve cord in the sea cucumber Holothuria glaberrima" @default.
• W2074001658 cites W1497324496 @default.
• W2074001658 cites W151558904 @default.
• W2074001658 cites W1527455107 @default.
• W2074001658 cites W1528334786 @default.
• W2074001658 cites W1656581071 @default.
• W2074001658 cites W1848217035 @default.
• W2074001658 cites W1968446099 @default.
• W2074001658 cites W1972476325 @default.
• W2074001658 cites W1976104966 @default.
• W2074001658 cites W1983949249 @default.
• W2074001658 cites W1985076834 @default.
• W2074001658 cites W1986702930 @default.
• W2074001658 cites W1989465144 @default.
• W2074001658 cites W1996911217 @default.
• W2074001658 cites W2002665943 @default.
• W2074001658 cites W2006227936 @default.
• W2074001658 cites W2016283470 @default.
• W2074001658 cites W2017354392 @default.
• W2074001658 cites W2017979401 @default.
• W2074001658 cites W2019667297 @default.
• W2074001658 cites W2037960828 @default.
• W2074001658 cites W2043182675 @default.
• W2074001658 cites W2044515702 @default.
• W2074001658 cites W2047369546 @default.
• W2074001658 cites W2050071277 @default.
• W2074001658 cites W2061161468 @default.
• W2074001658 cites W2061905894 @default.
• W2074001658 cites W2065889277 @default.
• W2074001658 cites W2066024574 @default.
• W2074001658 cites W2066924381 @default.
• W2074001658 cites W2067044409 @default.
• W2074001658 cites W2069235384 @default.
• W2074001658 cites W2072807131 @default.
• W2074001658 cites W2076731990 @default.
• W2074001658 cites W2079101699 @default.
• W2074001658 cites W2080149716 @default.
• W2074001658 cites W2080158904 @default.
• W2074001658 cites W2081713281 @default.
• W2074001658 cites W2089858189 @default.
• W2074001658 cites W2100661175 @default.
• W2074001658 cites W2113421082 @default.
• W2074001658 cites W2120009432 @default.
• W2074001658 cites W2147516699 @default.
• W2074001658 cites W2154745705 @default.
• W2074001658 cites W2156706834 @default.
• W2074001658 cites W2156899206 @default.
• W2074001658 cites W2160327770 @default.
• W2074001658 cites W2162236027 @default.
• W2074001658 cites W2168529612 @default.
• W2074001658 cites W2417640556 @default.
• W2074001658 cites W88550915 @default.
• W2074001658 doi "https://doi.org/10.1186/1471-213x-9-3" @default.
• W2074001658 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2640377" @default.
• W2074001658 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19126208" @default.
• W2074001658 hasPublicationYear "2009" @default.
• W2074001658 type Work @default.
• W2074001658 sameAs 2074001658 @default.
• W2074001658 citedByCount "36" @default.
• W2074001658 countsByYear W20740016582012 @default.
• W2074001658 countsByYear W20740016582013 @default.
• W2074001658 countsByYear W20740016582014 @default.
• W2074001658 countsByYear W20740016582015 @default.
• W2074001658 countsByYear W20740016582017 @default.
• W2074001658 countsByYear W20740016582018 @default.
• W2074001658 countsByYear W20740016582020 @default.
• W2074001658 countsByYear W20740016582021 @default.
• W2074001658 countsByYear W20740016582022 @default.
• W2074001658 countsByYear W20740016582023 @default.
• W2074001658 crossrefType "journal-article" @default.
• W2074001658 hasAuthorship W2074001658A5021386393 @default.
• W2074001658 hasAuthorship W2074001658A5066083022 @default.
• W2074001658 hasAuthorship W2074001658A5091462673 @default.
• W2074001658 hasBestOaLocation W20740016581 @default.
• W2074001658 hasConcept C105702510 @default.
• W2074001658 hasConcept C141071460 @default.
• W2074001658 hasConcept C169760540 @default.
• W2074001658 hasConcept C171056886 @default.
• W2074001658 hasConcept C18903297 @default.
• W2074001658 hasConcept C2776093933 @default.
• W2074001658 hasConcept C2777929075 @default.
• W2074001658 hasConcept C2779632786 @default.
• W2074001658 hasConcept C2780775167 @default.
• W2074001658 hasConcept C545706735 @default.
• W2074001658 hasConcept C71924100 @default.
• W2074001658 hasConcept C86803240 @default.
• W2074001658 hasConcept C95444343 @default.
• W2074001658 hasConceptScore W2074001658C105702510 @default.
• W2074001658 hasConceptScore W2074001658C141071460 @default.
• W2074001658 hasConceptScore W2074001658C169760540 @default.
• W2074001658 hasConceptScore W2074001658C171056886 @default.
• W2074001658 hasConceptScore W2074001658C18903297 @default.
• W2074001658 hasConceptScore W2074001658C2776093933 @default.

• next