FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2074280400> ?p ?o ?g. }

• W2074280400 endingPage "e2791" @default.
• W2074280400 startingPage "e2791" @default.
• W2074280400 abstract "True incidence of leprosy and its impact on transmission will not be understood until a tool is available to measure pre-symptomatic infection. Diagnosis of leprosy disease is currently based on clinical symptoms, which on average take 3-10 years to manifest. The fact that incidence, as defined by new case detection, equates with prevalence, i.e., registered cases, suggests that the cycle of transmission has not been fully intercepted by implementation of multiple drug therapy. This is supported by a high incidence of childhood leprosy. Epidemiological screening for pre-symptomatic leprosy in large endemic populations is required to facilitate targeted chemoprophylactic interventions. Such a test must be sensitive, specific, simple to administer, cost-effective, and easy to interpret. The intradermal skin test method that measures cell-mediated immunity was explored as the best option. Prior knowledge on skin testing of healthy subjects and leprosy patients with whole or partially fractionated Mycobacterium leprae bacilli, such as Lepromin or the Rees' or Convit' antigens, has established an acceptable safety and potency profile of these antigens. These data, along with immunoreactivity data, laid the foundation for two new leprosy skin test antigens, MLSA-LAM (M. leprae soluble antigen devoid of mycobacterial lipoglycans, primarily lipoarabinomannan) and MLCwA (M. leprae cell wall antigens). In the absence of commercial interest, the challenge was to develop these antigens under current good manufacturing practices in an acceptable local pilot facility and submit an Investigational New Drug to the Food and Drug Administration to allow a first-in-human phase I clinical trial." @default.
• W2074280400 created "2016-06-24" @default.
• W2074280400 creator A5012975065 @default.
• W2074280400 creator A5057583803 @default.
• W2074280400 creator A5078809657 @default.
• W2074280400 creator A5079244304 @default.
• W2074280400 date "2014-05-29" @default.
• W2074280400 modified "2023-10-03" @default.
• W2074280400 title "The Challenge of Producing Skin Test Antigens with Minimal Resources Suitable for Human Application against a Neglected Tropical Disease; Leprosy" @default.
• W2074280400 cites W132601408 @default.
• W2074280400 cites W1493323885 @default.
• W2074280400 cites W1497368584 @default.
• W2074280400 cites W1517406463 @default.
• W2074280400 cites W1523767929 @default.
• W2074280400 cites W1560324107 @default.
• W2074280400 cites W1573848297 @default.
• W2074280400 cites W184485255 @default.
• W2074280400 cites W1898836757 @default.
• W2074280400 cites W1904218657 @default.
• W2074280400 cites W1949772429 @default.
• W2074280400 cites W1952714621 @default.
• W2074280400 cites W1968307188 @default.
• W2074280400 cites W1970156510 @default.
• W2074280400 cites W1973789918 @default.
• W2074280400 cites W1982844300 @default.
• W2074280400 cites W1985782125 @default.
• W2074280400 cites W2010586126 @default.
• W2074280400 cites W2012800567 @default.
• W2074280400 cites W2017023111 @default.
• W2074280400 cites W2018647369 @default.
• W2074280400 cites W2033112850 @default.
• W2074280400 cites W2033436562 @default.
• W2074280400 cites W2043919339 @default.
• W2074280400 cites W2044107292 @default.
• W2074280400 cites W2047907368 @default.
• W2074280400 cites W2062214774 @default.
• W2074280400 cites W2067423107 @default.
• W2074280400 cites W2070721648 @default.
• W2074280400 cites W2079109812 @default.
• W2074280400 cites W2079432720 @default.
• W2074280400 cites W2088354306 @default.
• W2074280400 cites W2094722033 @default.
• W2074280400 cites W2097934914 @default.
• W2074280400 cites W2101108802 @default.
• W2074280400 cites W2103596694 @default.
• W2074280400 cites W2109872688 @default.
• W2074280400 cites W2110116899 @default.
• W2074280400 cites W2116467771 @default.
• W2074280400 cites W2119460480 @default.
• W2074280400 cites W2119707468 @default.
• W2074280400 cites W2123833457 @default.
• W2074280400 cites W2142272496 @default.
• W2074280400 cites W2154003425 @default.
• W2074280400 cites W2154601115 @default.
• W2074280400 cites W2159367931 @default.
• W2074280400 cites W2164123426 @default.
• W2074280400 cites W2167292122 @default.
• W2074280400 cites W2169420357 @default.
• W2074280400 cites W2170472470 @default.
• W2074280400 cites W2171760486 @default.
• W2074280400 cites W2186036781 @default.
• W2074280400 cites W2320158461 @default.
• W2074280400 cites W2328244334 @default.
• W2074280400 cites W2411953877 @default.
• W2074280400 cites W2993027330 @default.
• W2074280400 cites W47529322 @default.
• W2074280400 cites W76618182 @default.
• W2074280400 cites W1823595877 @default.
• W2074280400 doi "https://doi.org/10.1371/journal.pntd.0002791" @default.
• W2074280400 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4038479" @default.
• W2074280400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24874086" @default.
• W2074280400 hasPublicationYear "2014" @default.
• W2074280400 type Work @default.
• W2074280400 sameAs 2074280400 @default.
• W2074280400 citedByCount "7" @default.
• W2074280400 countsByYear W20742804002014 @default.
• W2074280400 countsByYear W20742804002016 @default.
• W2074280400 countsByYear W20742804002020 @default.
• W2074280400 countsByYear W20742804002021 @default.
• W2074280400 crossrefType "journal-article" @default.
• W2074280400 hasAuthorship W2074280400A5012975065 @default.
• W2074280400 hasAuthorship W2074280400A5057583803 @default.
• W2074280400 hasAuthorship W2074280400A5078809657 @default.
• W2074280400 hasAuthorship W2074280400A5079244304 @default.
• W2074280400 hasBestOaLocation W20742804001 @default.
• W2074280400 hasConcept C126322002 @default.
• W2074280400 hasConcept C142724271 @default.
• W2074280400 hasConcept C147483822 @default.
• W2074280400 hasConcept C203014093 @default.
• W2074280400 hasConcept C2776056871 @default.
• W2074280400 hasConcept C2777975735 @default.
• W2074280400 hasConcept C2779134260 @default.
• W2074280400 hasConcept C2779823659 @default.
• W2074280400 hasConcept C2780695269 @default.
• W2074280400 hasConcept C2781069245 @default.
• W2074280400 hasConcept C71924100 @default.
• W2074280400 hasConceptScore W2074280400C126322002 @default.
• W2074280400 hasConceptScore W2074280400C142724271 @default.

• next