FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2076398825> ?p ?o ?g. }

• W2076398825 abstract "For most mucosal epithelia including the ocular surface, it is generally believed that wound healing is executed by epithelial migration on the plane of erosion or ulceration. In explant cultures, we incidentally observed the phenomenon of intrastromal invasion by corneal, limbal and conjunctival epithelial cells even when cell migration on plastics was promoted. Homotypic and heterotypic tissue recombinants between corneal and conjunctival epithelial cells and their stroma revealed that this phenomena was dependent on viable mesenchymal cells and was more active in conjunctival stroma than corneal stroma. Using organotypic cultures in which 3T3 fibroblasts were incorporated in collagen gel, we noted that this phenomenon was fibroblast-dependent and up-regulated by lifting the culture to the air-fluid interphase. The extent of intrastromal invasion was decreased if 3T3 fibroblasts were treated with increasing concentrations of mitomycin C. The invading epithelial islands retained the same basal and suprabasal epithelial phenotypes as those of the surface epithelial layers using several anti-keratin monoclonal antibodies. Using 5-fluorouracil (5-FU) to eliminate the rapid-cycling, i.e. transient amplifying progenitor basal cells, we further noted that this phenomenon could still be produced by 5-FU-resistant slow-cycling progenitor cells of corneal, limbal and conjunctival explants. In organotypic cultures, conjunctival fibroblasts were more active than corneal fibroblasts in inducing corneal or conjunctival epithelial invasion. As such intrastromal invasion can experimentally be produced by normal non-transformed adult epithelial cells and mediated by fibroblasts, this in vitro phenomenon may be useful for studying the epithelial-mesenchymal interactions operating during embryonic development and post-natal wound healing." @default.
• W2076398825 created "2016-06-24" @default.
• W2076398825 creator A5032718030 @default.
• W2076398825 creator A5058115692 @default.
• W2076398825 date "1995-11-01" @default.
• W2076398825 modified "2023-10-15" @default.
• W2076398825 title "Differential intrastromal invasion by normal ocular surface epithelia is mediated by different fibroblasts" @default.
• W2076398825 cites W1561043766 @default.
• W2076398825 cites W1799131074 @default.
• W2076398825 cites W1971717847 @default.
• W2076398825 cites W1984294894 @default.
• W2076398825 cites W1985176515 @default.
• W2076398825 cites W2000622050 @default.
• W2076398825 cites W2000735803 @default.
• W2076398825 cites W2002344264 @default.
• W2076398825 cites W2003275504 @default.
• W2076398825 cites W2007904495 @default.
• W2076398825 cites W2008434851 @default.
• W2076398825 cites W2014888598 @default.
• W2076398825 cites W2016693266 @default.
• W2076398825 cites W2018552733 @default.
• W2076398825 cites W2019032943 @default.
• W2076398825 cites W2024721720 @default.
• W2076398825 cites W2035015033 @default.
• W2076398825 cites W2049065981 @default.
• W2076398825 cites W2051241694 @default.
• W2076398825 cites W2054774190 @default.
• W2076398825 cites W2060384681 @default.
• W2076398825 cites W2065102718 @default.
• W2076398825 cites W2066497153 @default.
• W2076398825 cites W2070228614 @default.
• W2076398825 cites W2070431772 @default.
• W2076398825 cites W2075024160 @default.
• W2076398825 cites W2089406104 @default.
• W2076398825 cites W2095841568 @default.
• W2076398825 cites W2118854821 @default.
• W2076398825 cites W2119226652 @default.
• W2076398825 cites W2121460110 @default.
• W2076398825 cites W2126332265 @default.
• W2076398825 cites W2128078747 @default.
• W2076398825 cites W2160668792 @default.
• W2076398825 cites W24809142 @default.
• W2076398825 cites W987547262 @default.
• W2076398825 doi "https://doi.org/10.1016/s0014-4835(05)80046-6" @default.
• W2076398825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8654495" @default.
• W2076398825 hasPublicationYear "1995" @default.
• W2076398825 type Work @default.
• W2076398825 sameAs 2076398825 @default.
• W2076398825 citedByCount "10" @default.
• W2076398825 countsByYear W20763988252013 @default.
• W2076398825 countsByYear W20763988252015 @default.
• W2076398825 countsByYear W20763988252017 @default.
• W2076398825 crossrefType "journal-article" @default.
• W2076398825 hasAuthorship W2076398825A5032718030 @default.
• W2076398825 hasAuthorship W2076398825A5058115692 @default.
• W2076398825 hasBestOaLocation W20763988251 @default.
• W2076398825 hasConcept C102230213 @default.
• W2076398825 hasConcept C104317684 @default.
• W2076398825 hasConcept C127561419 @default.
• W2076398825 hasConcept C141035611 @default.
• W2076398825 hasConcept C142724271 @default.
• W2076398825 hasConcept C169760540 @default.
• W2076398825 hasConcept C201750760 @default.
• W2076398825 hasConcept C203014093 @default.
• W2076398825 hasConcept C204232928 @default.
• W2076398825 hasConcept C2775984611 @default.
• W2076398825 hasConcept C2776882836 @default.
• W2076398825 hasConcept C2778266373 @default.
• W2076398825 hasConcept C2779257441 @default.
• W2076398825 hasConcept C2780269544 @default.
• W2076398825 hasConcept C2780381497 @default.
• W2076398825 hasConcept C28328180 @default.
• W2076398825 hasConcept C52124034 @default.
• W2076398825 hasConcept C529295009 @default.
• W2076398825 hasConcept C54355233 @default.
• W2076398825 hasConcept C55493867 @default.
• W2076398825 hasConcept C71924100 @default.
• W2076398825 hasConcept C76419328 @default.
• W2076398825 hasConcept C81885089 @default.
• W2076398825 hasConcept C86803240 @default.
• W2076398825 hasConcept C95444343 @default.
• W2076398825 hasConceptScore W2076398825C102230213 @default.
• W2076398825 hasConceptScore W2076398825C104317684 @default.
• W2076398825 hasConceptScore W2076398825C127561419 @default.
• W2076398825 hasConceptScore W2076398825C141035611 @default.
• W2076398825 hasConceptScore W2076398825C142724271 @default.
• W2076398825 hasConceptScore W2076398825C169760540 @default.
• W2076398825 hasConceptScore W2076398825C201750760 @default.
• W2076398825 hasConceptScore W2076398825C203014093 @default.
• W2076398825 hasConceptScore W2076398825C204232928 @default.
• W2076398825 hasConceptScore W2076398825C2775984611 @default.
• W2076398825 hasConceptScore W2076398825C2776882836 @default.
• W2076398825 hasConceptScore W2076398825C2778266373 @default.
• W2076398825 hasConceptScore W2076398825C2779257441 @default.
• W2076398825 hasConceptScore W2076398825C2780269544 @default.
• W2076398825 hasConceptScore W2076398825C2780381497 @default.
• W2076398825 hasConceptScore W2076398825C28328180 @default.
• W2076398825 hasConceptScore W2076398825C52124034 @default.
• W2076398825 hasConceptScore W2076398825C529295009 @default.
• W2076398825 hasConceptScore W2076398825C54355233 @default.

• next