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- W2076806265 abstract "Emerging and re-emerging vector-borne diseases represent an increasingly significant public health challenge. While geographic variation among populations of vector species for susceptibility to pathogen infection and vector competence has been thoroughly documented, relatively little attention has been devoted to understanding the ultimate evolutionary causes of this intraspecific variation. Local genetic drift is known to influence genetic differentiation among populations for a variety of container-inhabiting mosquito species, including Aedes albopictus. Because genetic drift is expected to reduce genetic variation and lead to the accumulation of (partially) recessive deleterious alleles, we hypothesized that reduced genetic variation might affect susceptibility to pathogen infection in a model pathogen-vector system. We therefore created replicate inbred (two generations of full-sib mating, expected f = 0.375) and control (expected f ≈ 0.07) lines of Ae. albopictus and measured life-history traits including larval survivorship, adult longevity, and female wing length (body size) as well as susceptibility to infection by a model pathogen, Plasmodium gallinaceum. Inbred mosquitoes had significantly reduced larval survivorship and female adult longevity but inbreeding did not affect male adult longevity or female wing length (body size). Furthermore, there was no effect of inbreeding on susceptibility to infection by P. gallinaceum. Therefore, while our results did not support the hypothesis that reduced genetic variation influences susceptibility to pathogen infection in this system, we did find evidence for an effect of reduced genetic variation on female adult longevity, an important component of vectorial capacity. We suggest that additional research is needed to elucidate the genetic underpinnings of intraspecific variation in traits related to disease transmission and discuss the implications of our results for the efficacy of creating transgenic strains refractory to disease transmission." @default.
- W2076806265 created "2016-06-24" @default.
- W2076806265 creator A5026173318 @default.
- W2076806265 creator A5069323728 @default.
- W2076806265 date "2010-07-01" @default.
- W2076806265 modified "2023-10-18" @default.
- W2076806265 title "Inbreeding depression affects life-history traits but not infection by Plasmodium gallinaceum in the Asian tiger mosquito, Aedes albopictus" @default.
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