FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077308889> ?p ?o ?g. }

• W2077308889 endingPage "832" @default.
• W2077308889 startingPage "819" @default.
• W2077308889 abstract "As described in the preceding paper (Arvanitis et al. J. Med. Chem. 1999, 42), anilinopyrimidines I were identified as potent antagonists of corticotropin-releasing hormone-1 receptor (CRH1-R, also referred to as corticotropin-releasing factor, CRF1-R). Our next goal was to understand the receptor-bound conformation of the antagonists and to use this information to help guide preclinical optimization of the series and to develop new leads. Since receptor structural information was not available, we assumed that these small, high-affinity antagonists would tend to bind in conformations at or energetically close to their global minima and that rigid analogues that maintained the important stereoelectronic features of the bound anilinopyrimidine would also bind tightly. Conformational preferences and barriers to rotation of the anilinopyrimidines were determined by semiempirical methods, and X-ray and variable-temperature NMR spectroscopy provided experimental results that correlated well with calculated structures. Using these data, a key dihedral angle was constrained to design fused-ring analogues, substituted N-arylpyrrolopyridines II, synthesis of which provided CRH1 receptor antagonists with potency equal to that of the initial congeneric leads (Ki = 1 nM) and which closely matched the conformation held by the original compound, as determined by crystallography. In addition to providing a useful template for further analogue synthesis, the study unequivocally determined the active conformation of the anilinopyrimidines. Theoretical and spectroscopic studies, synthesis, and receptor binding data are presented." @default.
• W2077308889 created "2016-06-24" @default.
• W2077308889 creator A5003287897 @default.
• W2077308889 creator A5004097383 @default.
• W2077308889 creator A5006710021 @default.
• W2077308889 creator A5021007539 @default.
• W2077308889 creator A5027174528 @default.
• W2077308889 creator A5029715184 @default.
• W2077308889 creator A5038021976 @default.
• W2077308889 creator A5044195251 @default.
• W2077308889 creator A5052253506 @default.
• W2077308889 creator A5059450418 @default.
• W2077308889 creator A5070532719 @default.
• W2077308889 creator A5078713847 @default.
• W2077308889 creator A5082760139 @default.
• W2077308889 creator A5085664125 @default.
• W2077308889 date "1999-02-17" @default.
• W2077308889 modified "2023-10-13" @default.
• W2077308889 title "Corticotropin-Releasing Hormone Receptor Antagonists: Framework Design and Synthesis Guided by Ligand Conformational Studies" @default.
• W2077308889 cites W1971210116 @default.
• W2077308889 cites W1974963512 @default.
• W2077308889 cites W2006930438 @default.
• W2077308889 cites W2032725109 @default.
• W2077308889 cites W2051140029 @default.
• W2077308889 cites W2063060349 @default.
• W2077308889 cites W2091379422 @default.
• W2077308889 cites W2095317731 @default.
• W2077308889 cites W2163865126 @default.
• W2077308889 cites W2171846995 @default.
• W2077308889 cites W3005087542 @default.
• W2077308889 doi "https://doi.org/10.1021/jm980223o" @default.
• W2077308889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10072680" @default.
• W2077308889 hasPublicationYear "1999" @default.
• W2077308889 type Work @default.
• W2077308889 sameAs 2077308889 @default.
• W2077308889 citedByCount "67" @default.
• W2077308889 countsByYear W20773088892012 @default.
• W2077308889 countsByYear W20773088892013 @default.
• W2077308889 countsByYear W20773088892014 @default.
• W2077308889 countsByYear W20773088892016 @default.
• W2077308889 countsByYear W20773088892017 @default.
• W2077308889 countsByYear W20773088892018 @default.
• W2077308889 countsByYear W20773088892022 @default.
• W2077308889 countsByYear W20773088892023 @default.
• W2077308889 crossrefType "journal-article" @default.
• W2077308889 hasAuthorship W2077308889A5003287897 @default.
• W2077308889 hasAuthorship W2077308889A5004097383 @default.
• W2077308889 hasAuthorship W2077308889A5006710021 @default.
• W2077308889 hasAuthorship W2077308889A5021007539 @default.
• W2077308889 hasAuthorship W2077308889A5027174528 @default.
• W2077308889 hasAuthorship W2077308889A5029715184 @default.
• W2077308889 hasAuthorship W2077308889A5038021976 @default.
• W2077308889 hasAuthorship W2077308889A5044195251 @default.
• W2077308889 hasAuthorship W2077308889A5052253506 @default.
• W2077308889 hasAuthorship W2077308889A5059450418 @default.
• W2077308889 hasAuthorship W2077308889A5070532719 @default.
• W2077308889 hasAuthorship W2077308889A5078713847 @default.
• W2077308889 hasAuthorship W2077308889A5082760139 @default.
• W2077308889 hasAuthorship W2077308889A5085664125 @default.
• W2077308889 hasConcept C112887158 @default.
• W2077308889 hasConcept C116569031 @default.
• W2077308889 hasConcept C170493617 @default.
• W2077308889 hasConcept C178790620 @default.
• W2077308889 hasConcept C185592680 @default.
• W2077308889 hasConcept C2776885963 @default.
• W2077308889 hasConcept C2780378348 @default.
• W2077308889 hasConcept C32909587 @default.
• W2077308889 hasConcept C55493867 @default.
• W2077308889 hasConcept C66974803 @default.
• W2077308889 hasConcept C71240020 @default.
• W2077308889 hasConcept C89025888 @default.
• W2077308889 hasConceptScore W2077308889C112887158 @default.
• W2077308889 hasConceptScore W2077308889C116569031 @default.
• W2077308889 hasConceptScore W2077308889C170493617 @default.
• W2077308889 hasConceptScore W2077308889C178790620 @default.
• W2077308889 hasConceptScore W2077308889C185592680 @default.
• W2077308889 hasConceptScore W2077308889C2776885963 @default.
• W2077308889 hasConceptScore W2077308889C2780378348 @default.
• W2077308889 hasConceptScore W2077308889C32909587 @default.
• W2077308889 hasConceptScore W2077308889C55493867 @default.
• W2077308889 hasConceptScore W2077308889C66974803 @default.
• W2077308889 hasConceptScore W2077308889C71240020 @default.
• W2077308889 hasConceptScore W2077308889C89025888 @default.
• W2077308889 hasIssue "5" @default.
• W2077308889 hasLocation W20773088891 @default.
• W2077308889 hasLocation W20773088892 @default.
• W2077308889 hasOpenAccess W2077308889 @default.
• W2077308889 hasPrimaryLocation W20773088891 @default.
• W2077308889 hasRelatedWork W2001861549 @default.
• W2077308889 hasRelatedWork W2073324450 @default.
• W2077308889 hasRelatedWork W2222132316 @default.
• W2077308889 hasRelatedWork W2226971040 @default.
• W2077308889 hasRelatedWork W2227667343 @default.
• W2077308889 hasRelatedWork W2238759361 @default.
• W2077308889 hasRelatedWork W2267416725 @default.
• W2077308889 hasRelatedWork W2271559003 @default.
• W2077308889 hasRelatedWork W2318107687 @default.
• W2077308889 hasRelatedWork W2337476911 @default.

• next