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• W2077366916 startingPage "118" @default.
• W2077366916 abstract "It is known that adipokines can regulate the hypothalamic–pituitary–adrenal axis (HPAA). In this study, we confirmed that adiponectin regulates the HPAA by affecting pituitary corticotroph cells. Using RT-PCR and immunofluorescence, we determined that adiponectin receptors were expressed in pituitary corticotroph tumour cells (AtT-20 cells and human corticotroph tumours). Adiponectin stimulated calcium influx and increased basal ACTH secretion without affecting corticotrophin-releasing hormone (CRH)-stimulated ACTH secretion, which was most likely due to the expression of adiponectin repressing CRH receptor 1 (CRHR1). Adiponectin also acutely stimulated ACTH release in primary culture pituitary cells. Lastly, adiponectin directly phosphorylated 5′ AMP-activated protein kinase (AMPK) in AtT-20 cells. The effects of adiponectin were mimicked by AICAR, which was blocked by compound C. Taken together, our results suggested that adiponectin stimulated ACTH secretion and down-regulated CRHR1, possibly via an AMPK-dependent mechanism in pituitary corticotroph cells." @default.
• W2077366916 created "2016-06-24" @default.
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• W2077366916 date "2014-03-01" @default.
• W2077366916 modified "2023-09-27" @default.
• W2077366916 title "Adiponectin regulates ACTH secretion and the HPAA in an AMPK-dependent manner in pituitary corticotroph cells" @default.
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• W2077366916 doi "https://doi.org/10.1016/j.mce.2013.12.007" @default.
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• W2077366916 hasPublicationYear "2014" @default.
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