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• W2077544314 abstract "The two isoforms of cyclooxygenase (COX) catalyze the initial step in the formation of biologically important prostanoids, such as prostaglandin (PG) E2, and thromboxane (TX) A2, in a variety of pathophysiologic processes. These include modulation of the inflammatory reaction, gastrointestinal (GI) cytoprotection and ulceration, angiogenesis and cancer, hemostasis and thrombosis, renal hemodynamics, and progression of kidney disease. Thus, it is not surprising that drugs inhibiting the activity of COX isozymes may have desirable as well as untoward effects on a variety of human diseases." @default.
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• W2077544314 date "2001-07-01" @default.
• W2077544314 modified "2023-09-29" @default.
• W2077544314 title "Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs" @default.
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• W2077544314 doi "https://doi.org/10.1172/jci13418" @default.
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