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• W2077599095 abstract "Presence of the apolipoprotein E (APOE) epsilon4 allele is linked to an increased risk to develop Alzheimer's dementia (AD). However, there are controversial data concerning the impact of the APOE genotype on cognitive functioning and brain activity in healthy subjects. We used event-related functional magnetic resonance imaging (fMRI) to investigate the effects of APOE genotype on spatial contextual memory encoding and retrieval success in healthy older adults. Eighteen subjects (eight APOE4 heterozygotes (epsilon4+) and 10 non-carriers (epsilon4-), mean age 60.0+/-5.0 years) were included in the present analysis. Behaviorally, epsilon4+ subjects performed significantly worse than epsilon4- subjects in item memory and spatial context retrieval. fMRI data revealed that epsilon4+ subjects, compared to epsilon4-subjects, predominantly showed an increase of neural activity specific to encoding of items and their spatial context in prefrontal, temporal and parietal regions. In contrast, epsilon4+ subjects showed activity decreases in the right amygdala during successful item recognition and in the prefrontal cortex bilaterally during spatial context retrieval when compared to epsilon4- subjects. While the activity increases during encoding may reflect compensatory activity in the attempt to maintain normal performance, the decreases during retrieval indicate incipient neural decline in epsilon4+ subjects. These data highlight that preclinical ApoE-related changes in neural activity are not unidirectional but dissociate depending on the memory phase, i.e., encoding or retrieval." @default.
• W2077599095 created "2016-06-24" @default.
• W2077599095 creator A5006315449 @default.
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• W2077599095 date "2010-06-01" @default.
• W2077599095 modified "2023-10-18" @default.
• W2077599095 title "Medial temporal lobe dysfunction during encoding and retrieval of episodic memory in non-demented APOE ε4 carriers" @default.
• W2077599095 cites W148236777 @default.
• W2077599095 cites W1655746131 @default.
• W2077599095 cites W1970006557 @default.
• W2077599095 cites W1986900475 @default.
• W2077599095 cites W1987906422 @default.
• W2077599095 cites W1988527674 @default.
• W2077599095 cites W1988760929 @default.
• W2077599095 cites W1995255547 @default.
• W2077599095 cites W1997071197 @default.
• W2077599095 cites W1997417397 @default.
• W2077599095 cites W1998535349 @default.
• W2077599095 cites W1999530134 @default.
• W2077599095 cites W2006534012 @default.
• W2077599095 cites W2009341341 @default.
• W2077599095 cites W2010031803 @default.
• W2077599095 cites W2011131455 @default.
• W2077599095 cites W2012076586 @default.
• W2077599095 cites W2015001118 @default.
• W2077599095 cites W2016938907 @default.
• W2077599095 cites W2017581860 @default.
• W2077599095 cites W2021526060 @default.
• W2077599095 cites W2023843351 @default.
• W2077599095 cites W2026462557 @default.
• W2077599095 cites W2028680001 @default.
• W2077599095 cites W2036362108 @default.
• W2077599095 cites W2038935818 @default.
• W2077599095 cites W2040178194 @default.
• W2077599095 cites W2040434160 @default.
• W2077599095 cites W2040481324 @default.
• W2077599095 cites W2046836290 @default.
• W2077599095 cites W2052530454 @default.
• W2077599095 cites W2056976370 @default.
• W2077599095 cites W2060629467 @default.
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• W2077599095 cites W2069014575 @default.
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• W2077599095 cites W2081877072 @default.
• W2077599095 cites W2087523117 @default.
• W2077599095 cites W2095221075 @default.
• W2077599095 cites W2095882961 @default.
• W2077599095 cites W2097608504 @default.
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• W2077599095 doi "https://doi.org/10.1016/j.neuroscience.2010.03.044" @default.
• W2077599095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20350587" @default.
• W2077599095 hasPublicationYear "2010" @default.
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