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• W2077838859 abstract "A rapid high performance liquid chromatographic method was developed and validated for the determination and stability evaluation of linezolid in pharmaceutical dosage forms. Separation of linezolid was successfully achieved on a C-18 column utilizing water: methanol (50:50 v/v) at a flow rate of 1 mL/min and eluate was monitored at 254 nm, with a retention time of 5.117 minute. The method was validated and the response was found to be linear in the drug concentration range of 0.001 mg/mL to 3.4 mg/mL. The mean values ± RSD of the slope and the correlation coefficient were found to be 51169 ± 0.290 and 0.9999, respectively. The RSD values for intra- and inter-day precision were found to be 0.782 (<1.00%) and 0.610 (<0.90%), respectively. The forced degradation kinetic study of linezolid by using HCl (0.5 N), NaOH (0.02 M), H2O2 (6%v/v), thermal (80 ± 2°C), and UV radiation (365 nm) were observed to be very specific." @default.
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• W2077838859 date "2011-11-01" @default.
• W2077838859 modified "2023-09-27" @default.
• W2077838859 title "VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR THE ESTIMATION OF LINEZOLID IN A PHARMACEUTICAL DOSAGE FORM" @default.
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• W2077838859 doi "https://doi.org/10.1080/10826076.2011.585548" @default.
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