Matches in SemOpenAlex for { <https://semopenalex.org/work/W2078290233> ?p ?o ?g. }
- W2078290233 endingPage "231" @default.
- W2078290233 startingPage "222" @default.
- W2078290233 abstract "Cross-reactive immunity occurs when infection with or vaccination against one virus protects against another related family member. A search for homologues of the HIV-1 envelope glycoprotein revealed that it is composed of thousands of intercalating and overlapping viral matches of pentapeptide or longer gapped consensi, belonging to over 70% of the currently sequenced virome, infecting all kingdoms from bacteria to man. It was also highly homologous to proteins from the Visna/Maedi and other ovine viruses, while other proteins (nef/tat/gag/pol) were homologous to proteins from the equine infectious anaemia virus and HTLV-2/HTLV-3 viruses. This phenomenon suggests that horizontal gene transfer from coinfecting RNA and DNA viruses to retroviruses is extensive, providing a route for the subsequent insertion of non-retroviral genes into human and other genomes via retroviral integration. This homology includes all viruses for which vaccines already exist. Cross-reactive immunity may be operative in AIDS, as Vaccinia vaccination decreases viral replication in HIV-1 infected patients' cells, for the CCR5 tropic form. Measles, Dengue virus, or GB virus C infections also decrease the HIV-1 viral load. A resumption of Vaccinia/smallpox vaccination might be expected to have a significant effect on the AIDS pandemic, and a careful study of the potential uses of other existing viral and bacterial vaccines merits close attention. This phenomenon may also be relevant to other recalcitrant viruses, bacteria, and parasites for which no vaccine exists and the armory of existing vaccines may have a role to play in diseases other than those for which they were designed." @default.
- W2078290233 created "2016-06-24" @default.
- W2078290233 creator A5000584525 @default.
- W2078290233 date "2011-08-19" @default.
- W2078290233 modified "2023-10-16" @default.
- W2078290233 title "Vaccinia and other viruses with available vaccines show marked homology with the HIV-1 envelope glycoprotein: The prospect of using existing vaccines to stem the AIDS pandemic" @default.
- W2078290233 cites W1483001195 @default.
- W2078290233 cites W1539682680 @default.
- W2078290233 cites W1829302344 @default.
- W2078290233 cites W188637119 @default.
- W2078290233 cites W1966333238 @default.
- W2078290233 cites W1970963541 @default.
- W2078290233 cites W1990558411 @default.
- W2078290233 cites W1991981496 @default.
- W2078290233 cites W1995205657 @default.
- W2078290233 cites W2002980831 @default.
- W2078290233 cites W2008143397 @default.
- W2078290233 cites W2019939821 @default.
- W2078290233 cites W2024890561 @default.
- W2078290233 cites W2025715508 @default.
- W2078290233 cites W2028212568 @default.
- W2078290233 cites W2037875426 @default.
- W2078290233 cites W2039337517 @default.
- W2078290233 cites W2044414242 @default.
- W2078290233 cites W2045815467 @default.
- W2078290233 cites W2059275162 @default.
- W2078290233 cites W2078362045 @default.
- W2078290233 cites W2080338710 @default.
- W2078290233 cites W2092770473 @default.
- W2078290233 cites W2099219682 @default.
- W2078290233 cites W2112695096 @default.
- W2078290233 cites W2124809056 @default.
- W2078290233 cites W2128480987 @default.
- W2078290233 cites W2129531904 @default.
- W2078290233 cites W2141677524 @default.
- W2078290233 cites W2141761862 @default.
- W2078290233 cites W2146102264 @default.
- W2078290233 cites W2150886925 @default.
- W2078290233 cites W2156073006 @default.
- W2078290233 cites W2160397907 @default.
- W2078290233 cites W2160896939 @default.
- W2078290233 cites W2161273650 @default.
- W2078290233 cites W2313965242 @default.
- W2078290233 cites W2414800935 @default.
- W2078290233 cites W2432889701 @default.
- W2078290233 cites W4322700630 @default.
- W2078290233 cites W1529317622 @default.
- W2078290233 doi "https://doi.org/10.3109/08923973.2011.596542" @default.
- W2078290233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21851326" @default.
- W2078290233 hasPublicationYear "2011" @default.
- W2078290233 type Work @default.
- W2078290233 sameAs 2078290233 @default.
- W2078290233 citedByCount "1" @default.
- W2078290233 countsByYear W20782902332017 @default.
- W2078290233 crossrefType "journal-article" @default.
- W2078290233 hasAuthorship W2078290233A5000584525 @default.
- W2078290233 hasBestOaLocation W20782902331 @default.
- W2078290233 hasConcept C104317684 @default.
- W2078290233 hasConcept C141231307 @default.
- W2078290233 hasConcept C159047783 @default.
- W2078290233 hasConcept C22070199 @default.
- W2078290233 hasConcept C2522874641 @default.
- W2078290233 hasConcept C2777760223 @default.
- W2078290233 hasConcept C2781356689 @default.
- W2078290233 hasConcept C40767141 @default.
- W2078290233 hasConcept C533803919 @default.
- W2078290233 hasConcept C54355233 @default.
- W2078290233 hasConcept C86803240 @default.
- W2078290233 hasConcept C8769409 @default.
- W2078290233 hasConcept C97380033 @default.
- W2078290233 hasConceptScore W2078290233C104317684 @default.
- W2078290233 hasConceptScore W2078290233C141231307 @default.
- W2078290233 hasConceptScore W2078290233C159047783 @default.
- W2078290233 hasConceptScore W2078290233C22070199 @default.
- W2078290233 hasConceptScore W2078290233C2522874641 @default.
- W2078290233 hasConceptScore W2078290233C2777760223 @default.
- W2078290233 hasConceptScore W2078290233C2781356689 @default.
- W2078290233 hasConceptScore W2078290233C40767141 @default.
- W2078290233 hasConceptScore W2078290233C533803919 @default.
- W2078290233 hasConceptScore W2078290233C54355233 @default.
- W2078290233 hasConceptScore W2078290233C86803240 @default.
- W2078290233 hasConceptScore W2078290233C8769409 @default.
- W2078290233 hasConceptScore W2078290233C97380033 @default.
- W2078290233 hasIssue "2" @default.
- W2078290233 hasLocation W20782902331 @default.
- W2078290233 hasLocation W20782902332 @default.
- W2078290233 hasLocation W20782902333 @default.
- W2078290233 hasOpenAccess W2078290233 @default.
- W2078290233 hasPrimaryLocation W20782902331 @default.
- W2078290233 hasRelatedWork W1272359955 @default.
- W2078290233 hasRelatedWork W161238046 @default.
- W2078290233 hasRelatedWork W2006327952 @default.
- W2078290233 hasRelatedWork W2039932125 @default.
- W2078290233 hasRelatedWork W2066465020 @default.
- W2078290233 hasRelatedWork W2070177503 @default.
- W2078290233 hasRelatedWork W2070261981 @default.
- W2078290233 hasRelatedWork W2078290233 @default.
- W2078290233 hasRelatedWork W2154271740 @default.