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• W2078366932 abstract "Bioavailability of oral drugs, particularly large hydrophilic agents, is often limited by poor adhesion and transport across gastrointestinal (GI) epithelial cells. Drug delivery systems, such as sub-micrometer polymer carriers (nanocarriers, NCs) coupled to affinity moieties that target GI surface markers involved in transport, may improve this aspect. To explore this strategy, we coated 100-nm polymer particles with an antibody to ICAM-1 (a protein expressed on the GI epithelium and other tissues) and evaluated targeting, uptake, and transport in human GI epithelial cells. Fluorescence and electron microscopy, and radioisotope tracing revealed that anti-ICAM NCs specifically bound to cells in culture, were internalized via CAM-mediated endocytosis, trafficked by transcytosis across cell monolayers without disrupting the permeability barrier or cell viability, and enabled transepithelial transport of a model therapeutic enzyme (α-galactosidase, deficient in lysosomal Fabry disease). These results indicate that ICAM-1 targeting may provide delivery of therapeutics, such as enzymes, to and across the GI epithelium." @default.
• W2078366932 created "2016-06-24" @default.
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• W2078366932 date "2012-10-01" @default.
• W2078366932 modified "2023-10-16" @default.
• W2078366932 title "Transport of nanocarriers across gastrointestinal epithelial cells by a new transcellular route induced by targeting ICAM-1" @default.
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• W2078366932 doi "https://doi.org/10.1016/j.jconrel.2012.06.007" @default.
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