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- W2078889389 abstract "We investigated whether intercellular adhesion molecule-1 (ICAM-1) transduces outside-in signals for the production of chemokines IL-8 and RANTES in endothelial cells. Cross-linking of ICAM-1 induced IL-8 and RANTES mRNA expressions and increased their protein synthesis and secretions in endothelial cells. Furthermore, ICAM-1 cross-linking activated 44- and 42-kDa mitogen-activated protein (MAP) kinases (ERK1 and ERK2) in endothelial cells, as indicated by the electrophoretic mobility shift of MAP kinases on SDS-polyacrylamide gels. Finally, the specific MEK inhibitor PD98059 inhibited ICAM-1-induced IL-8 and RANTES production in endothelial cells. Taken together, these results indicate that stimulation of ICAM-1 induces IL-8 and RANTES production through the activation of 44- and 42-kDa MAP kinases in endothelial cells, suggesting that ICAM-1-induced chemokine production in endothelial cells would further attract and activate leukocytes to induce intense inflammation." @default.
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- W2078889389 date "1998-09-01" @default.
- W2078889389 modified "2023-09-25" @default.
- W2078889389 title "Cross-linking of Intercellular Adhesion Molecule-1 Induces Interleukin-8 and RANTES Production through the Activation of MAP Kinases in Human Vascular Endothelial Cells" @default.
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- W2078889389 doi "https://doi.org/10.1006/bbrc.1998.9385" @default.
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