Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079584322> ?p ?o ?g. }
- W2079584322 endingPage "731" @default.
- W2079584322 startingPage "713" @default.
- W2079584322 abstract "Hydrodynamics-based gene delivery, involving a large-volume and high-speed intravenous injection of naked plasmid DNA (pDNA), gives a significantly high level of transgene expression in vivo. This has attracted a lot of attention and has been used very frequently as an efficient, simple and convenient transfection method for laboratory animals. Until recently, however, little information has been published on the pharmacokinetics of the injected DNA molecules and of the detailed mechanisms underlying the efficient gene transfer. We and other groups have very recently demonstrated that the mechanism for the hydrodynamics-based gene transfer would involve, in part, the direct cytosolic delivery of pDNA through the cell membrane due to transiently enhanced permeability. Along with the findings in our series of studies, this article reviews the cumulative reports and other intriguing information on the controlled pharmacokinetics of naked pDNA in the hydrodynamics-based gene delivery. In addition, we describe various applications reported so far, as well as the current attempts and proposals to develop novel gene medicines for future gene therapy using the concept of the hydrodynamics-based procedure. Furthermore, the issues associated with the clinical feasibility of its seemingly invasive nature, which is probably the most common concern about this hydrodynamics-based procedure, are discussed along with its future prospects and challenges." @default.
- W2079584322 created "2016-06-24" @default.
- W2079584322 creator A5035791716 @default.
- W2079584322 creator A5054830507 @default.
- W2079584322 creator A5071041099 @default.
- W2079584322 date "2005-04-01" @default.
- W2079584322 modified "2023-10-14" @default.
- W2079584322 title "The hydrodynamics-based procedure for controlling the pharmacokinetics of gene medicines at whole body, organ and cellular levels" @default.
- W2079584322 cites W1489905977 @default.
- W2079584322 cites W1496811300 @default.
- W2079584322 cites W1521637340 @default.
- W2079584322 cites W1570307043 @default.
- W2079584322 cites W1571966789 @default.
- W2079584322 cites W165015491 @default.
- W2079584322 cites W179683383 @default.
- W2079584322 cites W1917488124 @default.
- W2079584322 cites W1920681646 @default.
- W2079584322 cites W1958728059 @default.
- W2079584322 cites W1963652777 @default.
- W2079584322 cites W1963861474 @default.
- W2079584322 cites W1965668071 @default.
- W2079584322 cites W1969497292 @default.
- W2079584322 cites W1970761517 @default.
- W2079584322 cites W1972359936 @default.
- W2079584322 cites W1973911001 @default.
- W2079584322 cites W1974258947 @default.
- W2079584322 cites W1974273389 @default.
- W2079584322 cites W1974303227 @default.
- W2079584322 cites W1975572966 @default.
- W2079584322 cites W1976216196 @default.
- W2079584322 cites W1976665020 @default.
- W2079584322 cites W1978507399 @default.
- W2079584322 cites W1980764127 @default.
- W2079584322 cites W1981385560 @default.
- W2079584322 cites W1981425869 @default.
- W2079584322 cites W1981851660 @default.
- W2079584322 cites W1982193732 @default.
- W2079584322 cites W1982315438 @default.
- W2079584322 cites W1983335647 @default.
- W2079584322 cites W1983647080 @default.
- W2079584322 cites W1983874973 @default.
- W2079584322 cites W1984183802 @default.
- W2079584322 cites W1985425536 @default.
- W2079584322 cites W1986586535 @default.
- W2079584322 cites W1986655312 @default.
- W2079584322 cites W1987841399 @default.
- W2079584322 cites W1991182270 @default.
- W2079584322 cites W1991498195 @default.
- W2079584322 cites W1992501118 @default.
- W2079584322 cites W1993639279 @default.
- W2079584322 cites W1994946741 @default.
- W2079584322 cites W1996163490 @default.
- W2079584322 cites W1996671893 @default.
- W2079584322 cites W1997448874 @default.
- W2079584322 cites W1997954003 @default.
- W2079584322 cites W1999531505 @default.
- W2079584322 cites W1999707071 @default.
- W2079584322 cites W2000660705 @default.
- W2079584322 cites W2000696759 @default.
- W2079584322 cites W2000853857 @default.
- W2079584322 cites W2001556815 @default.
- W2079584322 cites W2002836909 @default.
- W2079584322 cites W2003492108 @default.
- W2079584322 cites W2003526255 @default.
- W2079584322 cites W2003575753 @default.
- W2079584322 cites W2003588837 @default.
- W2079584322 cites W2003896426 @default.
- W2079584322 cites W2005753837 @default.
- W2079584322 cites W2007651161 @default.
- W2079584322 cites W2011178958 @default.
- W2079584322 cites W2012547585 @default.
- W2079584322 cites W2014495927 @default.
- W2079584322 cites W2014976983 @default.
- W2079584322 cites W2017955222 @default.
- W2079584322 cites W2020923434 @default.
- W2079584322 cites W2021151310 @default.
- W2079584322 cites W2021693767 @default.
- W2079584322 cites W2022434236 @default.
- W2079584322 cites W2023103520 @default.
- W2079584322 cites W2024384131 @default.
- W2079584322 cites W2025180980 @default.
- W2079584322 cites W2025788293 @default.
- W2079584322 cites W2026247866 @default.
- W2079584322 cites W2026991428 @default.
- W2079584322 cites W2029175314 @default.
- W2079584322 cites W2029653860 @default.
- W2079584322 cites W2031096246 @default.
- W2079584322 cites W2032105230 @default.
- W2079584322 cites W2032307190 @default.
- W2079584322 cites W2032445686 @default.
- W2079584322 cites W2036110284 @default.
- W2079584322 cites W2037402545 @default.
- W2079584322 cites W2038937549 @default.
- W2079584322 cites W2040455712 @default.
- W2079584322 cites W2042928063 @default.
- W2079584322 cites W2043692200 @default.
- W2079584322 cites W2044365536 @default.
- W2079584322 cites W2044655390 @default.